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Peptide exosite inhibitors of factor VIIa as anticoagulants

Nature (London), 2000-03, Vol.404 (6777), p.465-470

2000

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A Novel Exosite on Coagulation Factor VIIa and Its Molecular Interactions with a New Class of Peptide Inhibitors

Biochemistry (Easton), 2001-08, Vol.40 (32), p.9522-9531

2001

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Platelet Glycoprotein IIb-IIIa Protein Antagonists from Snake Venoms: Evidence for a Family of Platelet-Aggregation Inhibitors

Proceedings of the National Academy of Sciences - PNAS, 1990-04, Vol.87 (7), p.2471-2475

1990

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Selection and Characterization of a New Class of Peptide Exosite Inhibitors of Coagulation Factor VIIa

Biochemistry (Easton), 2001-08, Vol.40 (32), p.9513-9521

2001

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Solution Structure of Kistrin, a Potent Platelet Aggregation Inhibitor and GP IIb-IIIa Antagonist

Science (American Association for the Advancement of Science), 1991-07, Vol.253 (5018), p.445-448

1991

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Mutational analysis of human DNase I at the DNA binding interface: Implications for DNA recognition, catalysis, and metal ion dependence

Protein science, 1998-03, Vol.7 (3), p.628-636

1998

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Structure of the RGD Protein Decorsin: Conserved Motif and Distinct Function in Leech Proteins That Affect Blood Clotting

Science (American Association for the Advancement of Science), 1994-06, Vol.264 (5167), p.1944-1947

1994

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Decorsin. A potent glycoprotein IIb-IIIa antagonist and platelet aggregation inhibitor from the leech Macrobdella decora

The Journal of biological chemistry, 1990-06, Vol.265 (17), p.10143-10147

1990

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Engineering Actin-Resistant Human DNase I for Treatment of Cystic Fibrosis

Proceedings of the National Academy of Sciences - PNAS, 1996-08, Vol.93 (16), p.8225-8229

1996

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Tissue Expression, Protease Specificity, and Kunitz Domain Functions of Hepatocyte Growth Factor Activator Inhibitor-1B (HAI-1B), a New Splice Variant of HAI-1

The Journal of biological chemistry, 2003-09, Vol.278 (38), p.36341-36349

2003

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Improved activity of an actin-resistant DNase I variant on the cystic fibrosis airway secretions

American journal of respiratory and critical care medicine, 2001-04, Vol.163 (5), p.1153-1157

2001

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Ca2+-dependent activity of human DNase I and its hyperactive variants

Protein science, 1999-09, Vol.8 (9), p.1780-1788

1999

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Mambin, a potent glycoprotein IIb-IIIa antagonist and platelet aggregation inhibitor structurally related to the short neurotoxins

Biochemistry (Easton), 1992-05, Vol.31 (20), p.4766-4772

1992

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Recombinant decorsin: Dynamics of the RGD recognition site

Protein science, 2000-08, Vol.9 (8), p.1428-1438

2000

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Binding interactions of kistrin with platelet glycoprotein IIb-IIIa: Analysis by site-directed mutagenesis

Proteins, structure, function, and bioinformatics, 1993-03, Vol.15 (3), p.312-321

1993

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Ecotin Is a Potent Anticoagulant and Reversible Tight-Binding Inhibitor of Factor Xa

Biochemistry (Easton), 1994-04, Vol.33 (13), p.3949-3958

1994

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Engineering Exosite Peptides for Complete Inhibition of Factor VIIa Using a Protease Switch with Substrate Phage

The Journal of biological chemistry, 2003-06, Vol.278 (24), p.21823-21830

2003

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The Factor VII Zymogen Structure Reveals Reregistration of β Strands during Activation

Structure (London), 2001-07, Vol.9 (7), p.627-636

2001

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Rubber Elongation by Farnesyl Pyrophosphate Synthases Involves a Novel Switch in Enzyme Stereospecificity

The Journal of biological chemistry, 1989-11, Vol.264 (31), p.18598-18607

1989

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Cysteine pairing in the glycoprotein IIbIIIa antagonist kistrin using NMR, chemical analysis, and structure calculations

Biochemistry (Easton), 1993-01, Vol.32 (1), p.282-289

1993

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Kunitz domain inhibitors of tissue factor-factor VIIa. I. Potent inhibitors selected from libraries by phage display

The Journal of biological chemistry, 1994-09, Vol.269 (35), p.22129-22136

1994

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Kistrin, and integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet α-granules

The Journal of clinical investigation, 1993, Vol.91 (1), p.193-200

1993

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Pathways for metabolism of ketoaldonic acids in an Erwinia sp

Journal of Bacteriology, 1991-11, Vol.173 (21), p.6651-6656

1991

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Kunitz domain inhibitors of tissue factor-factor VIIa. II. Potent and specific inhibitors by competitive phage selection

The Journal of biological chemistry, 1994-09, Vol.269 (35), p.22137-22144

1994

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A comparison of the effect of decorsin and two disintegrins, albolabrin and eristostatin, on platelet function

Thrombosis and haemostasis, 1995, Vol.74 (5), p.1316-1322

1995

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Peptide exosite inhibitors of factor VIIa as anticoagulants

A Novel Exosite on Coagulation Factor VIIa and Its Molecular Interactions with a New Class of Peptide Inhibitors

Platelet Glycoprotein IIb-IIIa Protein Antagonists from Snake Venoms: Evidence for a Family of Platelet-Aggregation Inhibitors

Selection and Characterization of a New Class of Peptide Exosite Inhibitors of Coagulation Factor VIIa

Solution Structure of Kistrin, a Potent Platelet Aggregation Inhibitor and GP IIb-IIIa Antagonist

Mutational analysis of human DNase I at the DNA binding interface: Implications for DNA recognition, catalysis, and metal ion dependence

Structure of the RGD Protein Decorsin: Conserved Motif and Distinct Function in Leech Proteins That Affect Blood Clotting

Decorsin. A potent glycoprotein IIb-IIIa antagonist and platelet aggregation inhibitor from the leech Macrobdella decora

Engineering Actin-Resistant Human DNase I for Treatment of Cystic Fibrosis

Tissue Expression, Protease Specificity, and Kunitz Domain Functions of Hepatocyte Growth Factor Activator Inhibitor-1B (HAI-1B), a New Splice Variant of HAI-1

Improved activity of an actin-resistant DNase I variant on the cystic fibrosis airway secretions

Ca2+-dependent activity of human DNase I and its hyperactive variants

Mambin, a potent glycoprotein IIb-IIIa antagonist and platelet aggregation inhibitor structurally related to the short neurotoxins

Recombinant decorsin: Dynamics of the RGD recognition site

Binding interactions of kistrin with platelet glycoprotein IIb-IIIa: Analysis by site-directed mutagenesis

Ecotin Is a Potent Anticoagulant and Reversible Tight-Binding Inhibitor of Factor Xa

Engineering Exosite Peptides for Complete Inhibition of Factor VIIa Using a Protease Switch with Substrate Phage

The Factor VII Zymogen Structure Reveals Reregistration of β Strands during Activation

Rubber Elongation by Farnesyl Pyrophosphate Synthases Involves a Novel Switch in Enzyme Stereospecificity

Cysteine pairing in the glycoprotein IIbIIIa antagonist kistrin using NMR, chemical analysis, and structure calculations

Kunitz domain inhibitors of tissue factor-factor VIIa. I. Potent inhibitors selected from libraries by phage display

Kistrin, and integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet α-granules

Pathways for metabolism of ketoaldonic acids in an Erwinia sp

Kunitz domain inhibitors of tissue factor-factor VIIa. II. Potent and specific inhibitors by competitive phage selection

A comparison of the effect of decorsin and two disintegrins, albolabrin and eristostatin, on platelet function

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