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Allosteric modulation of the muscarinic M₄ receptor as an approach to treating schizophrenia

Proceedings of the National Academy of Sciences - PNAS, 2008-08, Vol.105 (31), p.10978-10983

2008

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Allosterism at muscarinic receptors: ligands and mechanisms

Mini reviews in medicinal chemistry, 2005-06, Vol.5 (6), p.523

2005

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Thiochrome Enhances Acetylcholine Affinity at Muscarinic M4 Receptors: Receptor Subtype Selectivity via Cooperativity Rather than Affinity

Molecular pharmacology, 2004-01, Vol.65 (1), p.257

2004

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Thiochrome Enhances Acetylcholine Affinity at Muscarinic M 4 Receptors: Receptor Subtype Selectivity via Cooperativity Rather than Affinity

Molecular pharmacology, 2004-01, Vol.65 (1), p.257-266

2004

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Analogs of WIN 62,577 Define a Second Allosteric Site on Muscarinic Receptors

Molecular pharmacology, 2002-12, Vol.62 (6), p.1492-1505

2002

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Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors

Molecular pharmacology, 1995-08, Vol.48 (2), p.362-378

1995

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Subtype-Selective Positive Cooperative Interactions between Brucine Analogues and Acetylcholine at Muscarinic Receptors: Radioligand Binding Studies

Molecular pharmacology, 1998-03, Vol.53 (3), p.573-589

1998

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Measurement of agonist-stimulated [35S]GTP gamma S binding to cell membranes

Methods in molecular biology (Clifton, N.J.), 1999, Vol.106, p.231

Lazareno, S

1999

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Measurement of agonist-stimulated [35S]GTP gamma S binding to cell membranes

Methods in molecular biology (Clifton, N.J.), 1997, Vol.83, p.107

Lazareno, S

1997

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Estimation of competitive antagonist affinity from functional inhibition curves using the Gaddum, Schild and Cheng‐Prusoíf equations

British journal of pharmacology, 1993-08, Vol.109 (4), p.1110-1119

1993

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Estimation of competitive antagonist affinity from functional inhibition curves using the Gaddum, Schild and Cheng-Prusoff equations

British journal of pharmacology, 1993-08, Vol.109 (4), p.1110-1119

1993

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Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis

Molecular pharmacology, 1995-01, Vol.47 (1), p.88-98

1995

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Pharmacological characterization of acetylcholine‐stimulated [35S]‐GTPγS binding mediated by human muscarinic m1–m4 receptors: antagonist studies

British journal of pharmacology, 1993-08, Vol.109 (4), p.1120-1127

1993

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Estimation of antagonist Kb from inhibition curves in functional experiments : alternatives to the Cheng-Prusoff equation

Trends in pharmacological sciences (Regular ed.), 1993-06, Vol.14 (6), p.237-239

1993

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Allosteric modulation of the muscarinic M 4 receptor as an approach to treating schizophrenia

Proceedings of the National Academy of Sciences - PNAS, 2008-08, Vol.105 (31), p.10978-10983

2008

Volltextzugriff (PDF)

GraphPad Prism (version 1.02)

Trends in pharmacological sciences (Regular ed.), 1994-09, Vol.15 (9), p.353-354

Lazareno, S.

1994

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Allosteric interactions between the antagonist prazosin and amiloride analogs at the human alpha(1A)-adrenergic receptor

Molecular pharmacology, 2000-03, Vol.57 (3), p.436-445

2000

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Allosteric regulation of muscarinic receptors

Progress in brain research, 1996, Vol.109, p.147-151

1996

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Stereoselective recognition of the enantiomers of phenglutarimide and of six related compounds by four muscarinic receptor subtypes

British journal of pharmacology, 1996-12, Vol.119 (7), p.1319-1330

1996

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The effects of saponin on the binding and functional properties of the human adenosine A1 receptor

British journal of pharmacology, 1996-04, Vol.117 (7), p.1521-1529

1996

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Functional and binding studies with muscarinic M2‐subtype selective antagonists

British journal of pharmacology, 1989-09, Vol.98 (1), p.309-317

1989

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Quantitation of allosteric interactions

Trends in pharmacological sciences (Regular ed.), 1996-12, Vol.17 (12), p.443

1996

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Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site

Molecular pharmacology, 2000-07, Vol.58 (1), p.194-207

2000

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Allosteric regulation of G-protein-linked receptors

Biochemical Society transactions, 1995-02, Vol.23 (1), p.108

1995

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Interactions of Orthosteric and Allosteric Ligands with [ 3 H]Dimethyl-W84 at the Common Allosteric Site of Muscarinic M 2 Receptors

Molecular pharmacology, 2003-07, Vol.64 (1), p.180-190

2003

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Allosteric modulation of the muscarinic M₄ receptor as an approach to treating schizophrenia

Allosterism at muscarinic receptors: ligands and mechanisms

Thiochrome Enhances Acetylcholine Affinity at Muscarinic M4 Receptors: Receptor Subtype Selectivity via Cooperativity Rather than Affinity

Thiochrome Enhances Acetylcholine Affinity at Muscarinic M 4 Receptors: Receptor Subtype Selectivity via Cooperativity Rather than Affinity

Analogs of WIN 62,577 Define a Second Allosteric Site on Muscarinic Receptors

Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors

Subtype-Selective Positive Cooperative Interactions between Brucine Analogues and Acetylcholine at Muscarinic Receptors: Radioligand Binding Studies

Measurement of agonist-stimulated [35S]GTP gamma S binding to cell membranes

Measurement of agonist-stimulated [35S]GTP gamma S binding to cell membranes

Estimation of competitive antagonist affinity from functional inhibition curves using the Gaddum, Schild and Cheng‐Prusoíf equations

Estimation of competitive antagonist affinity from functional inhibition curves using the Gaddum, Schild and Cheng-Prusoff equations

Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis

Pharmacological characterization of acetylcholine‐stimulated [35S]‐GTPγS binding mediated by human muscarinic m1–m4 receptors: antagonist studies

Estimation of antagonist Kb from inhibition curves in functional experiments : alternatives to the Cheng-Prusoff equation

Allosteric modulation of the muscarinic M 4 receptor as an approach to treating schizophrenia

GraphPad Prism (version 1.02)

Allosteric interactions between the antagonist prazosin and amiloride analogs at the human alpha(1A)-adrenergic receptor

Allosteric regulation of muscarinic receptors

Stereoselective recognition of the enantiomers of phenglutarimide and of six related compounds by four muscarinic receptor subtypes

The effects of saponin on the binding and functional properties of the human adenosine A1 receptor

Functional and binding studies with muscarinic M2‐subtype selective antagonists

Quantitation of allosteric interactions

Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site

Allosteric regulation of G-protein-linked receptors

Interactions of Orthosteric and Allosteric Ligands with [ 3 H]Dimethyl-W84 at the Common Allosteric Site of Muscarinic M 2 Receptors

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