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Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions

Journal of endocrinology, 2018-02, Vol.236 (2), p.R109-R143

2018

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A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?

Diabetes (New York, N.Y.), 2016-06, Vol.65 (6), p.1472-1480

2016

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Macrophage alterations in islets of obese mice linked to beta cell disruption in diabetes

Diabetologia, 2019-06, Vol.62 (6), p.993-999

2019

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Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction

Diabetes (New York, N.Y.), 2008-10, Vol.57 (10), p.2728-2736

2008

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Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity

Nature communications, 2021-05, Vol.12 (1), p.2622-2622, Article 2622

2021

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XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice

Diabetologia, 2022-06, Vol.65 (6), p.984-996

2022

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Circular RNAs as novel regulators of β-cell functions in normal and disease conditions

Molecular metabolism (Germany), 2018-03, Vol.9, p.69-83

2018

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Iron chelation increases beige fat differentiation and metabolic activity, preventing and treating obesity

Scientific reports, 2022-01, Vol.12 (1), p.776-776, Article 776

2022

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Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans

Diabetologia, 2019-12, Vol.62 (12), p.2273-2286

2019

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Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells

Diabetologia, 2016-07, Vol.59 (7), p.1492-1502

2016

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A fluorescent timer reporter enables sorting of insulin secretory granules by age

The Journal of biological chemistry, 2020-07, Vol.295 (27), p.8901-8911

2020

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Heparan sulfate proteoglycans in beta cells provide a critical link between endoplasmic reticulum stress, oxidative stress and type 2 diabetes

PloS one, 2021-06, Vol.16 (6), p.e0252607-e0252607

2021

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Phlda3 regulates beta cell survival during stress

Scientific reports, 2019-09, Vol.9 (1), p.12827-13, Article 12827

2019

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Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: Possible contribution to impaired incretin effects in diabetes

Diabetes (New York, N.Y.), 2007-06, Vol.56 (6), p.1551-1558

2007

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Y1 receptor deficiency in β-cells leads to increased adiposity and impaired glucose metabolism

Scientific reports, 2018-09, Vol.8 (1), p.11835-11, Article 11835

2018

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A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking

Biochemical journal, 2011-04, Vol.435 (1), p.267-276

2011

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Inhibition of Y1 receptor signaling improves islet transplant outcome

Nature communications, 2017-09, Vol.8 (1), p.490-12, Article 490

2017

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Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance

PloS one, 2012-02, Vol.7 (2), p.e30816-e30816

2012

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Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant–mitochondrial response in mouse beta cells

Diabetologia, 2015-04, Vol.58 (4), p.758-770

2015

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Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

Diabetes (New York, N.Y.), 2008-11, Vol.57 (11), p.3034-3044

2008

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Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and Above Metal Homeostasis and Antioxidant Response

Biology (Basel, Switzerland), 2021-02, Vol.10 (3), p.176

2021

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Pancreatic PYY Is Critical in the Control of Insulin Secretion and Glucose Homeostasis in Female Mice

Endocrinology (Philadelphia), 2015-09, Vol.156 (9), p.3122-3136

2015

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On-target action of anti-tropomyosin drugs regulates glucose metabolism

Scientific reports, 2018-03, Vol.8 (1), p.4604-13, Article 4604

2018

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Inhibition of Id1 Augments Insulin Secretion and Protects Against High-Fat Diet-Induced Glucose Intolerance

Diabetes (New York, N.Y.), 2011-10, Vol.60 (10), p.2506-2514

2011

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Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions

A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?

Macrophage alterations in islets of obese mice linked to beta cell disruption in diabetes

Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction

Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity

XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice

Circular RNAs as novel regulators of β-cell functions in normal and disease conditions

Iron chelation increases beige fat differentiation and metabolic activity, preventing and treating obesity

Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans

Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells

A fluorescent timer reporter enables sorting of insulin secretory granules by age

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

Heparan sulfate proteoglycans in beta cells provide a critical link between endoplasmic reticulum stress, oxidative stress and type 2 diabetes

Phlda3 regulates beta cell survival during stress

Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: Possible contribution to impaired incretin effects in diabetes

Y1 receptor deficiency in β-cells leads to increased adiposity and impaired glucose metabolism

A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking

Inhibition of Y1 receptor signaling improves islet transplant outcome

Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance

Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant–mitochondrial response in mouse beta cells

Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and Above Metal Homeostasis and Antioxidant Response

Pancreatic PYY Is Critical in the Control of Insulin Secretion and Glucose Homeostasis in Female Mice

On-target action of anti-tropomyosin drugs regulates glucose metabolism

Inhibition of Id1 Augments Insulin Secretion and Protects Against High-Fat Diet-Induced Glucose Intolerance

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