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Rings in Clinical Trials and Drugs: Present and Future

Journal of medicinal chemistry, 2022-07, Vol.65 (13), p.8699-8712

2022

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Importance of Rigidity in Designing Small Molecule Drugs To Tackle Protein-Protein Interactions (PPIs) through Stabilization of Desired Conformers

Journal of medicinal chemistry, 2018-05, Vol.61 (10), p.4283-4289

2018

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Isolation of antigen-specific, disulphide-rich knob domain peptides from bovine antibodies

PLoS biology, 2020-09, Vol.18 (9), p.e3000821-e3000821

2020

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Bimekizumab, a Novel Humanized IgG1 Antibody That Neutralizes Both IL-17A and IL-17F

Frontiers in immunology, 2020-08, Vol.11, p.1894-1894

2020

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A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF

Nature communications, 2021-01, Vol.12 (1), p.583-10, Article 583

2021

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Rings in drugs

Journal of medicinal chemistry, 2014-07, Vol.57 (14), p.5845-5859

2014

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Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism

Chemical science (Cambridge), 2023-07, Vol.14 (27), p.7524-7536

2023

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The Chemical Synthesis of Knob Domain Antibody Fragments

ACS chemical biology, 2021-09, Vol.16 (9), p.1757-1769

2021

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Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR

PLoS biology, 2018-05, Vol.16 (5), p.e2006192-e2006192

2018

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Natural Conformational Sampling of Human TNFα Visualized by Double Electron-Electron Resonance

Biophysical journal, 2017-07, Vol.113 (2), p.371-380

2017

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A computational method for predicting the aggregation propensity of IgG1 and IgG4(P) mAbs in common storage buffers

mAbs, 2022, Vol.14 (1), p.2138092-2138092

2022

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The Loss of Telomerase Activity in Highly Differentiated CD8+CD28-CD27- T Cells Is Associated with Decreased Akt (Ser473) Phosphorylation

The Journal of immunology (1950), 2007-06, Vol.178 (12), p.7710-7719

2007

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Modular design of bi- and multi-specific knob domain fusions

Frontiers in immunology, 2024, Vol.15, p.1384467-1384467

2024

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Small Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of Dynamics

Molecules, 2015-09, Vol.20 (9), p.16435-16445

2015

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Serum albumin binding knob domains engineered within a VH framework III bispecific antibody format and as chimeric peptides

Frontiers in immunology, 2023-05, Vol.14, p.1170357-1170357

2023

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Identification and characterisation of anti-IL-13 inhibitory single domain antibodies provides new insights into receptor selectivity and attractive opportunities for drug discovery

Frontiers in immunology, 2023-07, Vol.14, p.1216967-1216967

2023

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Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping

Scientific reports, 2017-01, Vol.7 (1), p.41306-41306, Article 41306

2017

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Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL-17F contributes to human chronic tissue inflammation

Annals of the rheumatic diseases, 2018-04, Vol.77 (4), p.523

2018

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Combining Molecular Scaffolds from FDA Approved Drugs: Application to Drug Discovery

Journal of medicinal chemistry, 2017-03, Vol.60 (5), p.1638-1647

2017

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Creation of a gated antibody as a conditionally functional synthetic protein

Nature communications, 2014-07, Vol.5 (1), p.4388-4388, Article 4388

2014

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Antibody-enabled small-molecule drug discovery

Nature reviews. Drug discovery, 2012-07, Vol.11 (7), p.519-525

Lawson, Alastair D G

2012

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Insights Into the Structure-Function Relationships of Dimeric C3d Fragments

Frontiers in immunology, 2021-08, Vol.12, p.714055-714055

2021

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Phage Display of Bovine Ultralong CDRH3

Methods in molecular biology (Clifton, N.J.), 2023, Vol.2681, p.83

2023

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Rings in Clinical Trials and Drugs: Present and Future

Importance of Rigidity in Designing Small Molecule Drugs To Tackle Protein-Protein Interactions (PPIs) through Stabilization of Desired Conformers

Isolation of antigen-specific, disulphide-rich knob domain peptides from bovine antibodies

Bimekizumab, a Novel Humanized IgG1 Antibody That Neutralizes Both IL-17A and IL-17F

A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF

Rings in drugs

Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism

The Chemical Synthesis of Knob Domain Antibody Fragments

Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR

Natural Conformational Sampling of Human TNFα Visualized by Double Electron-Electron Resonance

A computational method for predicting the aggregation propensity of IgG1 and IgG4(P) mAbs in common storage buffers

The Loss of Telomerase Activity in Highly Differentiated CD8+CD28-CD27- T Cells Is Associated with Decreased Akt (Ser473) Phosphorylation

Modular design of bi- and multi-specific knob domain fusions

Small Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of Dynamics

Serum albumin binding knob domains engineered within a VH framework III bispecific antibody format and as chimeric peptides

Identification and characterisation of anti-IL-13 inhibitory single domain antibodies provides new insights into receptor selectivity and attractive opportunities for drug discovery

Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping

Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL-17F contributes to human chronic tissue inflammation

Combining Molecular Scaffolds from FDA Approved Drugs: Application to Drug Discovery

Creation of a gated antibody as a conditionally functional synthetic protein

Antibody-enabled small-molecule drug discovery

Insights Into the Structure-Function Relationships of Dimeric C3d Fragments

The rapid generation of recombinant functional monoclonal antibodies from individual, antigen-specific bone marrow-derived plasma cells isolated using a novel fluorescence-based method

Phage Display of Bovine Ultralong CDRH3

The allosteric modulation of complement C5 by knob domain peptides

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