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Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs

The Journal of biological chemistry, 2003-04, Vol.278 (14), p.11979-11984

2003

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Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences

Journal of molecular biology, 2004-01, Vol.335 (2), p.547-554

2004

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Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation

The Journal of biological chemistry, 2017-10, Vol.292 (43), p.17963-17974

2017

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Host Cell Factor Requirement for Hepatitis C Virus Enzyme Maturation

Proceedings of the National Academy of Sciences - PNAS, 2001-11, Vol.98 (24), p.13931-13935

2001

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Fragment Based Drug Design: Tools, Practical Approaches, and Examples

Kuo, Lawrence C

1, 2011

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Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5677-5682

2007

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Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2007-11, Vol.17 (21), p.5989-5994

2007

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Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution

Protein science, 2011-04, Vol.20 (4), p.670-683

2011

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How to Avoid Rediscovering the Known

Methods in Enzymology, 2011, Vol.493, p.159-168

Kuo, Lawrence C.

2011

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Optimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors

Bioorganic & medicinal chemistry letters, 2011-08, Vol.21 (16), p.4762-4767

2011

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Only a Small Fraction of Purified Hepatitis C RNA-Dependent RNA Polymerase Is Catalytically Competent: Implications for Viral Replication and in Vitro Assays

Biochemistry (Easton), 2000-07, Vol.39 (28), p.8243-8249

2000

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Electron Density Guided Fragment-Based Lead Discovery of Ketohexokinase Inhibitors

Journal of medicinal chemistry, 2010-11, Vol.53 (22), p.7979-7991

2010

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Fragment-based drug design - tools, practical approaches, and examples. Preface

Methods in enzymology, 2011, Vol.493, p.xxi-xxii

Kuo, Lawrence C

2011

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Viral polymerases and related proteins

Carroll, Steven S

1996

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Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 Å resolution

Acta crystallographica. Section D, Biological crystallography., 2003-10, Vol.59 (10), p.1725-1730

2003

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Identification of MK-944a: A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors

Journal of medicinal chemistry, 2000-09, Vol.43 (18), p.3386-3399

2000

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Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1775-1779

2006

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Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (12), p.3175-3179

2006

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Screening and characterization of human monoglyceride lipase active site inhibitors using orthogonal binding and functional assays

Journal of biomolecular screening, 2012-06, Vol.17 (5), p.629-640

2012

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Discovery and Evaluation of Potent P1 Aryl Heterocycle-Based Thrombin Inhibitors

Journal of medicinal chemistry, 2004-06, Vol.47 (12), p.2995-3008

2004

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3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6

Bioorganic & medicinal chemistry letters, 2006-12, Vol.16 (23), p.6049-6053

2006

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Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1780-1783

2006

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Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity

The Journal of biological chemistry, 2002-10, Vol.277 (41), p.38797-38802

2002

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Dissociation and association of the HIV-1 protease dimer subunits: Equilibria and rates

Biochemistry (Easton), 1994-01, Vol.33 (1), p.98-105

1994

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Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs

Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences

Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation

Host Cell Factor Requirement for Hepatitis C Virus Enzyme Maturation

Fragment Based Drug Design: Tools, Practical Approaches, and Examples

Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP

Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors

Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution

Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

How to Avoid Rediscovering the Known

Optimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors

Only a Small Fraction of Purified Hepatitis C RNA-Dependent RNA Polymerase Is Catalytically Competent: Implications for Viral Replication and in Vitro Assays

Electron Density Guided Fragment-Based Lead Discovery of Ketohexokinase Inhibitors

Fragment-based drug design - tools, practical approaches, and examples. Preface

Viral polymerases and related proteins

Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 Å resolution

Identification of MK-944a: A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors

Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP

Screening and characterization of human monoglyceride lipase active site inhibitors using orthogonal binding and functional assays

Discovery and Evaluation of Potent P1 Aryl Heterocycle-Based Thrombin Inhibitors

3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6

Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity

Dissociation and association of the HIV-1 protease dimer subunits: Equilibria and rates

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