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Managing the challenge of chemically reactive metabolites in drug development

Nature reviews. Drug discovery, 2011-04, Vol.10 (4), p.292-306

2011

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The Innovative Medicines Initiative -10 Years of Public-Private Collaboration

Frontiers in medicine, 2019-12, Vol.6, p.275-275

2019

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Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies

The Lancet (British edition), 2009-04, Vol.373 (9671), p.1264-1274

2009

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Prevention and reduction of scarring in the skin by Transforming Growth Factor beta 3 (TGFβ3): from laboratory discovery to clinical pharmaceutical

Journal of biomaterials science. Polymer ed., 2008-01, Vol.19 (8), p.1047-1063

2008

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Assessing the Safety of Stem Cell Therapeutics

Cell stem cell, 2011-06, Vol.8 (6), p.618-628

2011

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Retraction Note: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity

Molecular medicine (Cambridge, Mass.), 2020-12, Vol.26 (1), p.130-1, Article 130

2020

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Discovery and development of avotermin (recombinant human transforming growth factor beta 3): A new class of prophylactic therapeutic for the improvement of scarring

Wound repair and regeneration, 2011-09, Vol.19 (s1), p.s38-s48

2011

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Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity

Molecular medicine (Cambridge, Mass.), 2010-11, Vol.16 (11-12), p.479-490

2010

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Expression of Concern to: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatoxicity

Molecular medicine (Cambridge, Mass.), 2020-01, Vol.26 (1), p.13-13, Article 13

2020

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potential of cytokines as safety biomarkers for drug-induced liver injury

European journal of clinical pharmacology, 2010-10, Vol.66 (10), p.961-976

2010

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Editorial: The Innovative Medicines Initiative - collaborations are key to innovating R&D processes

Biotechnology journal, 2014-09, Vol.9 (9), p.1095-1096

2014

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Boosting drug development through public-private partnerships – The IMI model

The EPMA journal, 2014-02, Vol.5 (Suppl 1), p.1-A11, Article A11

Laverty, Hugh

2014

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Assessing the Safety of Stem Cell Therapeutics

Cell stem cell, 2011-08, Vol.9 (2), p.176-176

2011

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The innovative medicines initiative: a case study for new ways of working in drug R&D

Future medicinal chemistry, 2014-04, Vol.6 (5), p.489-491

2014

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Effects of Avotermin (Transforming Growth Factor β3) in a Clinically Relevant Pig Model of Long, Full-Thickness Incisional Wounds

Journal of cutaneous medicine and surgery, 2010-09, Vol.14 (5), p.223-232

2010

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Mapping and expression analysis of the human CASK gene

Mammalian genome, 2000-10, Vol.11 (10), p.934-937

2000

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Intellectual property rights in collaborative drug development in the EU: helping a European public-private partnership deliver - the need for a flexible approach to IPR

Marquette intellectual property law review, 2014-01, Vol.18 (1), p.31

2014

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Improving R&D productivity of pharmaceutical companies through public-private partnership: experiences from the Innovative Medicines Initiative

Expert review of pharmacoeconomics & outcomes research, 2012-10, Vol.12 (5), p.545-548

2012

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'Big data' in pharmaceutical science: challenges and opportunities

Future medicinal chemistry, 2014-05, Vol.6 (8), p.857-864

2014

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A synthetic gene increases TGFβ3 accumulation by 75-fold in tobacco chloroplasts enabling rapid purification and folding into a biologically active molecule

Plant biotechnology journal, 2011-06, Vol.9 (5), p.618-628

2011

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Modified mouse model of tumourigenisis: Utility in the evaluation of the safety of therapeutics for cutaneous scar reduction

Toxicology (Amsterdam), 2010, Vol.278 (3), p.343-344

2010

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A synthetic gene increases TGFβ3 accumulation by 75-fold in tobacco chloroplasts enabling rapid purification and folding into a biologically active molecule: Chloroplast Biotechnology

Plant biotechnology journal, 2011, Vol.9 (5), p.618-628

2011

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Managing the challenge of chemically reactive metabolites in drug development

Nature reviews. Drug discovery, 2011-04, Vol.10 (4), p.292

2011

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Murine CASK Is Disrupted in a Sex-Linked Cleft Palate Mouse Mutant

Genomics (San Diego, Calif.), 1998-10, Vol.53 (1), p.29-41

1998

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Managing the challenge of chemically reactive metabolites in drug development

The Innovative Medicines Initiative -10 Years of Public-Private Collaboration

Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies

Prevention and reduction of scarring in the skin by Transforming Growth Factor beta 3 (TGFβ3): from laboratory discovery to clinical pharmaceutical

Assessing the Safety of Stem Cell Therapeutics

Retraction Note: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity

Discovery and development of avotermin (recombinant human transforming growth factor beta 3): A new class of prophylactic therapeutic for the improvement of scarring

Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity

Expression of Concern to: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatoxicity

potential of cytokines as safety biomarkers for drug-induced liver injury

What public health challenges and unmet medical needs would benefit from interdisciplinary collaboration in the EU? A survey and multi-stakeholder debate

Editorial: The Innovative Medicines Initiative - collaborations are key to innovating R&D processes

Boosting drug development through public-private partnerships – The IMI model

Assessing the Safety of Stem Cell Therapeutics

The innovative medicines initiative: a case study for new ways of working in drug R&D

Effects of Avotermin (Transforming Growth Factor β3) in a Clinically Relevant Pig Model of Long, Full-Thickness Incisional Wounds

Mapping and expression analysis of the human CASK gene

Intellectual property rights in collaborative drug development in the EU: helping a European public-private partnership deliver - the need for a flexible approach to IPR

Improving R&D productivity of pharmaceutical companies through public-private partnership: experiences from the Innovative Medicines Initiative

'Big data' in pharmaceutical science: challenges and opportunities

A synthetic gene increases TGFβ3 accumulation by 75-fold in tobacco chloroplasts enabling rapid purification and folding into a biologically active molecule

Modified mouse model of tumourigenisis: Utility in the evaluation of the safety of therapeutics for cutaneous scar reduction

A synthetic gene increases TGFβ3 accumulation by 75-fold in tobacco chloroplasts enabling rapid purification and folding into a biologically active molecule: Chloroplast Biotechnology

Managing the challenge of chemically reactive metabolites in drug development

Murine CASK Is Disrupted in a Sex-Linked Cleft Palate Mouse Mutant

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