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BCX-1812 (RWJ-270201): Discovery of a Novel, Highly Potent, Orally Active, and Selective Influenza Neuraminidase Inhibitor through Structure-Based Drug Design

Journal of medicinal chemistry, 2000-09, Vol.43 (19), p.3482-3486

2000

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Structure−Activity Relationship Studies of Novel Carbocyclic Influenza Neuraminidase Inhibitors

Journal of medicinal chemistry, 1998-07, Vol.41 (14), p.2451-2460

1998

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Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine Cores

Journal of medicinal chemistry, 2001-04, Vol.44 (8), p.1192-1201

2001

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Crystal Structure of a Bacterial Sialidase (From Salmonella typhimurium LT2) Shows the Same Fold as an Influenza Virus Neuraminidase

Proceedings of the National Academy of Sciences - PNAS, 1993-11, Vol.90 (21), p.9852-9856

1993

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Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex

Journal of molecular biology, 1992-09, Vol.227 (1), p.122-148

1992

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Novel α- and β-Amino Acid Inhibitors of Influenza Virus Neuraminidase

Antimicrobial Agents and Chemotherapy, 2001-09, Vol.45 (9), p.2563-2570

2001

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Potent Inhibition of Influenza Sialidase by a Benzoic Acid Containing a 2-Pyrrolidinone Substituent

Journal of medicinal chemistry, 1999-07, Vol.42 (13), p.2332-2343

1999

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Design and Synthesis of Benzoic Acid Derivatives as Influenza Neuraminidase Inhibitors Using Structure-Based Drug Design

Journal of medicinal chemistry, 1997-12, Vol.40 (25), p.4030-4052

1997

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Three-dimensional Structure of Influenza A N9 Neuraminidase and Its Complex with the Inhibitor 2-Deoxy 2,3-Dehydro- N-Acetyl Neuraminic Acid

Journal of molecular biology, 1993, Vol.232 (4), p.1069-1083

1993

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Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 resolution

Nature (London), 1983-05, Vol.303 (5912), p.35-40

1983

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Three-dimensional structure of a complex of antibody with influenza virus neuraminidase

Nature (London), 1987-03, Vol.326 (6111), p.358-363

1987

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Structure of the catalytic and antigenic sites in influenza virus neuraminidase

Nature (London), 1983-05, Vol.303 (5912), p.41-44

1983

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Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site: Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Anti-Influenza Activity

Journal of the American Chemical Society, 1997-01, Vol.119 (4), p.681-690

1997

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Hydrophobic benzoic acids as inhibitors of influenza neuraminidase

Bioorganic & medicinal chemistry, 1999-11, Vol.7 (11), p.2487-2497

1999

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Molecular mechanisms of variation in influenza viruses

Nature (London), 1982-03, Vol.296 (5853), p.115-121

1982

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Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants

Journal of molecular biology, 1991-09, Vol.221 (2), p.487-497

1991

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Structure-Based Inhibitors of Influenza Virus Sialidase. A Benzoic Acid Lead with Novel Interaction

Journal of medicinal chemistry, 1995-08, Vol.38 (17), p.3217-3225

1995

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Antibody Epitopes on the Neuraminidase of a Recent H3N2 Influenza Virus (A/Memphis/31/98)

Journal of Virology, 2002-12, Vol.76 (23), p.12274-12280

2002

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Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface

Journal of molecular biology, 1992-09, Vol.227 (1), p.149-159

1992

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Antigenicity of the N8 influenza A virus neuraminidase: existence of an epitope at the subunit interface of the neuraminidase

Journal of Virology, 1994-03, Vol.68 (3), p.1790-1796

1994

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Drug Development in Space?

Science (American Association for the Advancement of Science), 1999-06, Vol.284 (5423), p.2089-2089

Laver, W. Graeme

1999

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Evolutionary Changes in Influenza B are Not Primarily Governed by Antibody Selection

Proceedings of the National Academy of Sciences - PNAS, 1990-05, Vol.87 (10), p.3884-3888

1990

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Isolation of a biologically active soluble form of the hemagglutinin-neuraminidase protein of Sendai virus

Journal of Virology, 1988-12, Vol.62 (12), p.4653-4660

1988

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Antigenic structure and variation in an influenza virus N9 neuraminidase

Journal of Virology, 1987-09, Vol.61 (9), p.2910-2916

1987

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Three-dimensional structures of influenza virus neuraminidase-antibody complexes

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1989-06, Vol.323 (1217), p.511-518

1989

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BCX-1812 (RWJ-270201): Discovery of a Novel, Highly Potent, Orally Active, and Selective Influenza Neuraminidase Inhibitor through Structure-Based Drug Design

Structure−Activity Relationship Studies of Novel Carbocyclic Influenza Neuraminidase Inhibitors

Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine Cores

Crystal Structure of a Bacterial Sialidase (From Salmonella typhimurium LT2) Shows the Same Fold as an Influenza Virus Neuraminidase

Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex

Novel α- and β-Amino Acid Inhibitors of Influenza Virus Neuraminidase

Potent Inhibition of Influenza Sialidase by a Benzoic Acid Containing a 2-Pyrrolidinone Substituent

Design and Synthesis of Benzoic Acid Derivatives as Influenza Neuraminidase Inhibitors Using Structure-Based Drug Design

Three-dimensional Structure of Influenza A N9 Neuraminidase and Its Complex with the Inhibitor 2-Deoxy 2,3-Dehydro- N-Acetyl Neuraminic Acid

Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 resolution

Three-dimensional structure of a complex of antibody with influenza virus neuraminidase

Structure of the catalytic and antigenic sites in influenza virus neuraminidase

Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site: Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Anti-Influenza Activity

Hydrophobic benzoic acids as inhibitors of influenza neuraminidase

Molecular mechanisms of variation in influenza viruses

Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants

Structure-Based Inhibitors of Influenza Virus Sialidase. A Benzoic Acid Lead with Novel Interaction

Antibody Epitopes on the Neuraminidase of a Recent H3N2 Influenza Virus (A/Memphis/31/98)

Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface

Antigenicity of the N8 influenza A virus neuraminidase: existence of an epitope at the subunit interface of the neuraminidase

Drug Development in Space?

Evolutionary Changes in Influenza B are Not Primarily Governed by Antibody Selection

Isolation of a biologically active soluble form of the hemagglutinin-neuraminidase protein of Sendai virus

Antigenic structure and variation in an influenza virus N9 neuraminidase

Three-dimensional structures of influenza virus neuraminidase-antibody complexes

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