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Mathematical modeling and simulation in animal health - Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment

Journal of veterinary pharmacology and therapeutics, 2016-10, Vol.39 (5), p.421-438

2016

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Developing Exposure/Response Models for Anticancer Drug Treatment: Special Considerations

CPT: pharmacometrics and systems pharmacology, 2015-01, Vol.4 (1), p.12-27

2015

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Qualitative and quantitative assessment of drug-drug interaction potential in man, based on Ki, IC50 and inhibitor concentration

Current drug metabolism, 2004-04, Vol.5 (2), p.147

2004

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Revising axis V for DSM-IV: a review of measures of social functioning

The American journal of psychiatry, 1992-09, Vol.149 (9), p.1148-1156

1992

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Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

Clinical pharmacokinetics, 1999-03, Vol.36 (3), p.211-231

1999

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Prediction of hepatic metabolic clearance: Comparison and assessment of prediction models

Clinical pharmacokinetics, 2001, Vol.40 (7), p.553-563

2001

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Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes

European journal of pharmaceutical sciences, 2004-10, Vol.23 (2), p.189-199

2004

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Challenges and opportunities with modelling and simulation in drug discovery and drug development

Xenobiotica, 2007-10, Vol.37 (10-11), p.1295-1310

2007

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Combining in Vitro and in Vivo Pharmacokinetic Data for Prediction of Hepatic Drug Clearance in Humans by Artificial Neural Networks and Multivariate Statistical Techniques

Journal of medicinal chemistry, 1999-12, Vol.42 (25), p.5072-5076

1999

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The use of human hepatocytes to select compounds based on their expected hepatic extraction ratios in humans

Pharmaceutical research, 1997-02, Vol.14 (2), p.152-155

1997

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A novel strategy for physiologically based predictions of human pharmacokinetics

Clinical pharmacokinetics, 2006-01, Vol.45 (5), p.511-542

2006

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Ethyl methanesulfonate toxicity in Viracept—A comprehensive human risk assessment based on threshold data for genotoxicity

Toxicology letters, 2009-11, Vol.190 (3), p.317-329

2009

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Inevitable recidivism—The origin and centrality of an urban legend

International journal of law and psychiatry, 2011-05, Vol.34 (3), p.186-194

Lave, Tamara Rice

2011

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Mass Spectrometry-Based Quantification of CYP Enzymes to Establish In Vitro/In Vivo Scaling Factors for Intestinal and Hepatic Metabolism in Beagle Dog

Pharmaceutical research, 2012-07, Vol.29 (7), p.1832-1842

2012

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An Evaluation of the Utility of Physiologically Based Models of Pharmacokinetics in Early Drug Discovery

Journal of pharmaceutical sciences, 2005-10, Vol.94 (10), p.2327-2343

2005

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The Palgrave Handbook of Critical Physical Geography

1, 2018

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Prediction of intestinal absorption: comparative assessment of gastroplus™ and idea

European journal of pharmaceutical sciences, 2002-10, Vol.17 (1), p.51-61

2002

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Interspecies Pharmacokinetic Comparisons and Allometric Scaling of Napsagatran, a Low Molecular Weight Thrombin Inhibitor

Journal of pharmacy and pharmacology, 1999-01, Vol.51 (1), p.85-91

1999

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Comparison of clearance predictions using primary cultures and suspensions of human hepatocytes

Xenobiotica, 2005-01, Vol.35 (1), p.1-15

2005

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Application of Full Physiological Models for Pharmaceutical Drug Candidate Selection and Extrapolation of Pharmacokinetics to Man

Basic & clinical pharmacology & toxicology, 2005-03, Vol.96 (3), p.193-199

2005

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Bosentan, a new endothelin receptor antagonist: prediction of the systemic plasma clearance in man from combined in vivo and in vitro data

Xenobiotica, 1995, Vol.25 (12), p.1381-1390

1995

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Public Perception of the Risks of Floods: Implications for Communication

Risk analysis, 1991-06, Vol.11 (2), p.255-267

1991

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Interspecies scaling of bosentan, a new endothelin receptor antagonist and integration of in vitro data into allometric scaling

Pharmaceutical research, 1996-01, Vol.13 (1), p.97-101

1996

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Modelling of patient EMS exposure: Translating pharmacokinetics of EMS in vitro and in animals into patients

Toxicology letters, 2009-11, Vol.190 (3), p.310-316

2009

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Predictors of mortality shortly after entering a long-term care facility

Age and ageing, 2024-05, Vol.53 (5)

2024

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Mathematical modeling and simulation in animal health - Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment

Developing Exposure/Response Models for Anticancer Drug Treatment: Special Considerations

Qualitative and quantitative assessment of drug-drug interaction potential in man, based on Ki, IC50 and inhibitor concentration

Revising axis V for DSM-IV: a review of measures of social functioning

Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

Prediction of hepatic metabolic clearance: Comparison and assessment of prediction models

Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes

Challenges and opportunities with modelling and simulation in drug discovery and drug development

Combining in Vitro and in Vivo Pharmacokinetic Data for Prediction of Hepatic Drug Clearance in Humans by Artificial Neural Networks and Multivariate Statistical Techniques

The use of human hepatocytes to select compounds based on their expected hepatic extraction ratios in humans

A novel strategy for physiologically based predictions of human pharmacokinetics

Ethyl methanesulfonate toxicity in Viracept—A comprehensive human risk assessment based on threshold data for genotoxicity

Inevitable recidivism—The origin and centrality of an urban legend

Mass Spectrometry-Based Quantification of CYP Enzymes to Establish In Vitro/In Vivo Scaling Factors for Intestinal and Hepatic Metabolism in Beagle Dog

An Evaluation of the Utility of Physiologically Based Models of Pharmacokinetics in Early Drug Discovery

The Palgrave Handbook of Critical Physical Geography

Prediction of intestinal absorption: comparative assessment of gastroplus™ and idea

Interspecies Pharmacokinetic Comparisons and Allometric Scaling of Napsagatran, a Low Molecular Weight Thrombin Inhibitor

Comparison of clearance predictions using primary cultures and suspensions of human hepatocytes

Application of Full Physiological Models for Pharmaceutical Drug Candidate Selection and Extrapolation of Pharmacokinetics to Man

Bosentan, a new endothelin receptor antagonist: prediction of the systemic plasma clearance in man from combined in vivo and in vitro data

Public Perception of the Risks of Floods: Implications for Communication

Interspecies scaling of bosentan, a new endothelin receptor antagonist and integration of in vitro data into allometric scaling

Modelling of patient EMS exposure: Translating pharmacokinetics of EMS in vitro and in animals into patients

Predictors of mortality shortly after entering a long-term care facility

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