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AlphaFold 2 and NMR Spectroscopy: Partners to Understand Protein Structure, Dynamics and Function

Frontiers in molecular biosciences, 2022-05, Vol.9, p.906437-906437

Laurents, Douglas V

2022

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Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau

Nature communications, 2022-08, Vol.13 (1), p.4586-4586, Article 4586

2022

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Aromatic and aliphatic residues of the disordered region of TDP-43 are on a fast track for self-assembly

Biochemical and biophysical research communications, 2021-11, Vol.578, p.110-114

2021

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Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation

PLoS biology, 2016-04, Vol.14 (4), p.e1002447-e1002447

2016

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Phe-Gly motifs drive fibrillization of TDP-43's prion-like domain condensates

PLoS biology, 2021-04, Vol.19 (4), p.e3001198-e3001198

2021

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Architectonic principles of polyproline II helix bundle protein domains

Archives of biochemistry and biophysics, 2024-06, Vol.756, p.109981, Article 109981

2024

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The TDP‐43 N‐terminal domain structure at high resolution

The FEBS journal, 2016-04, Vol.283 (7), p.1242-1260

2016

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Insight into polyproline II helical bundle stability in an antifreeze protein denatured state

Biophysical journal, 2022-12, Vol.121 (23), p.4560-4568

2022

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Probing structural changes during amyloid aggregation of the sweet protein MNEI

The FEBS journal, 2020-07, Vol.287 (13), p.2808-2822

2020

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Do polyproline II helix associations modulate biomolecular condensates?

FEBS open bio, 2021-09, Vol.11 (9), p.2390-2399

2021

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Cohesin-dockerin code in cellulosomal dual binding modes and its allosteric regulation by proline isomerization

Structure (London), 2021-06, Vol.29 (6), p.587-597.e8

2021

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Conformational Priming of RepA-WH1 for Functional Amyloid Conversion Detected by NMR Spectroscopy

Structure (London), 2020-03, Vol.28 (3), p.336-347.e4

2020

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RNA binding proteins: Diversity from microsurgeons to cowboys

Biochimica et biophysica acta. Gene regulatory mechanisms, 2019-11, Vol.1862 (11-12), p.194398-194398, Article 194398

2019

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Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions

The Journal of biological chemistry, 2017-07, Vol.292 (28), p.11992-12006

2017

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Structural transitions in Orb2 prion-like domain relevant for functional aggregation in memory consolidation

The Journal of biological chemistry, 2020-12, Vol.295 (52), p.18122-18133

2020

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Metamorphism in TDP-43 prion-like domain determines chaperone recognition

Nature communications, 2023-01, Vol.14 (1), p.466-466, Article 466

2023

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Disorder and partial folding in the regulatory subunit hinge region of Trypanosoma brucei protein kinase A: The C-linker portion inhibits the parasite's protein kinase A

Archives of biochemistry and biophysics, 2021-02, Vol.698, p.108731-108731, Article 108731

2021

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Common features at the start of the neurodegeneration cascade

PLoS biology, 2012-05, Vol.10 (5), p.e1001335

2012

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Fused in sarcoma undergoes cold denaturation: Implications for phase separation

Protein science, 2023-01, Vol.32 (1), p.e4521-n/a

2023

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An Amyloid-Like Pathological Conformation of TDP-43 Is Stabilized by Hypercooperative Hydrogen Bonds

Frontiers in molecular neuroscience, 2016-11, Vol.9, p.125-125

2016

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Dimerization of Human Angiogenin and of Variants Involved in Neurodegenerative Diseases

International journal of molecular sciences, 2021-09, Vol.22 (18), p.10068

2021

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The Singular NMR Fingerprint of a Polyproline II Helical Bundle

Journal of the American Chemical Society, 2018-12, Vol.140 (49), p.16988-17000

2018

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Double domain swapping in bovine seminal RNase: formation of distinct N- and C-swapped tetramers and multimers with increasing biological activities

PloS one, 2012-10, Vol.7 (10), p.e46804

2012

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Phase separation modulates the functional amyloid assembly of human CPEB3

Progress in neurobiology, 2023-12, Vol.231, p.102540-102540, Article 102540

2023

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Solution conformation of a cohesin module and its scaffoldin linker from a prototypical cellulosome

Archives of biochemistry and biophysics, 2018-04, Vol.644, p.1-7

2018

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AlphaFold 2 and NMR Spectroscopy: Partners to Understand Protein Structure, Dynamics and Function

Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau

Aromatic and aliphatic residues of the disordered region of TDP-43 are on a fast track for self-assembly

Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation

Phe-Gly motifs drive fibrillization of TDP-43's prion-like domain condensates

Architectonic principles of polyproline II helix bundle protein domains

The TDP‐43 N‐terminal domain structure at high resolution

Insight into polyproline II helical bundle stability in an antifreeze protein denatured state

Probing structural changes during amyloid aggregation of the sweet protein MNEI

Do polyproline II helix associations modulate biomolecular condensates?

Cohesin-dockerin code in cellulosomal dual binding modes and its allosteric regulation by proline isomerization

Conformational Priming of RepA-WH1 for Functional Amyloid Conversion Detected by NMR Spectroscopy

RNA binding proteins: Diversity from microsurgeons to cowboys

Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions

Structural transitions in Orb2 prion-like domain relevant for functional aggregation in memory consolidation

Metamorphism in TDP-43 prion-like domain determines chaperone recognition

Disorder and partial folding in the regulatory subunit hinge region of Trypanosoma brucei protein kinase A: The C-linker portion inhibits the parasite's protein kinase A

Common features at the start of the neurodegeneration cascade

Fused in sarcoma undergoes cold denaturation: Implications for phase separation

An Amyloid-Like Pathological Conformation of TDP-43 Is Stabilized by Hypercooperative Hydrogen Bonds

Dimerization of Human Angiogenin and of Variants Involved in Neurodegenerative Diseases

The Singular NMR Fingerprint of a Polyproline II Helical Bundle

Double domain swapping in bovine seminal RNase: formation of distinct N- and C-swapped tetramers and multimers with increasing biological activities

Phase separation modulates the functional amyloid assembly of human CPEB3

Solution conformation of a cohesin module and its scaffoldin linker from a prototypical cellulosome

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