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IL‐1β and IL‐18: inflammatory markers or mediators of hypertension?

British journal of pharmacology, 2014-12, Vol.171 (24), p.5589-5602

2014

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Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt‐induced hypertension in mice

British journal of pharmacology, 2016-02, Vol.173 (4), p.752-765

2016

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Crystalline structure of pulverized dental calculus induces cell death in oral epithelial cells

Journal of periodontal research, 2018-06, Vol.53 (3), p.353-361

2018

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NLRP3 inflammasome activation in inflammaging

Seminars in immunology, 2018-12, Vol.40, p.61-73

2018

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Getting Closer to the Dirty Little Secret

Immunity (Cambridge, Mass.), 2011-04, Vol.34 (4), p.455-458

2011

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NLRP3 inflammasomes link inflammation and metabolic disease

Trends in immunology, 2011-08, Vol.32 (8), p.373-379

2011

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Intestinal microbiota modulates susceptibility to acetaminophen induced acute liver injury

Journal of hepatology, 2018, Vol.68, p.S71-S72

2018

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Population pharmacokinetic analysis of ten phase II clinical trials of pemetrexed in cancer patients

Cancer chemotherapy and pharmacology, 2006-04, Vol.57 (4), p.401-411

2006

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Phase I and Pharmacokinetic Study of Pemetrexed Administered Every 3 Weeks to Advanced Cancer Patients With Normal and Impaired Renal Function

Journal of clinical oncology, 2006-02, Vol.24 (4), p.552-562

2006

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Targeting the NLRP3 inflammasome in inflammatory diseases

Nature reviews. Drug discovery, 2018-08, Vol.17 (8), p.588-606

2018

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Differential role of NLRP3 inflammasome during acute and chronic cholestatic liver injury

Journal of hepatology, 2017, Vol.66 (1), p.S653-S653

2017

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A phase I study of pemetrexed (LY23I5I4) supplemented with folate and vitamin B12 in japanese patients with solid tumours

British journal of cancer, 2006-09, Vol.95 (6), p.677-682

2006

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IFI16 is an innate immune sensor for intracellular DNA

Nature immunology, 2010-11, Vol.11 (11), p.997

2010

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O020 Influenza a virus protein PB1-F2 activates the NLRP3 inflammasome to induce inflammation

Cytokine (Philadelphia, Pa.), 2012-09, Vol.59 (3), p.506-506

2012

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Phase I and Pharmacokinetic Study of Pemetrexed with High-Dose Folic Acid Supplementation or Multivitamin Supplementation in Patients with Locally Advanced or Metastatic Cancer

Clinical cancer research, 2007-05, Vol.13 (9), p.2675-2683

2007

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O070 : CX3CR1 is a gatekeeper for intestinal barrier integrity: Limiting steatohepatitis by promoting intestinal homeostasis

Journal of hepatology, 2015-04, Vol.62, p.S225-S225

2015

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A semimechanistic-physiologic population pharmacokinetic/ pharmacodynamic model for neutropenia following pemetrexed therapy

Cancer chemotherapy and pharmacology, 2006-04, Vol.57 (4), p.412-426

2006

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Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment

Nature communications, 2022-07, Vol.13 (1), p.3964-3964, Article 3964

2022

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Clinical application of a semimechanistic-physiologic population PK/PD model for neutropenia following pemetrexed therapy

Cancer chemotherapy and pharmacology, 2006-04, Vol.57 (4), p.427-435

2006

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NOX-free inflammasome activation

Blood, 2010-09, Vol.116 (9), p.1393-1394

Latz, Eicke

2010

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Population Pharmacokinetic/Pharmacodynamic Analyses of Pemetrexed and Neutropenia: Effect of Vitamin Supplementation and Differences between Japanese and Western Patients

Clinical cancer research, 2009-01, Vol.15 (1), p.346-354

2009

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Phase I and Pharmacokinetic Study of Pemetrexed plus Cisplatin in Chemonaive Patients with Locally Advanced or Metastatic Malignant Pleural Mesothelioma or Non–Small Cell Lung Cancer

Clinical cancer research, 2009-01, Vol.15 (1), p.382-389

2009

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Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

Immunity (Cambridge, Mass.), 2012-04, Vol.36 (4), p.561-571

2012

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Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

Gut, 2010-09, Vol.59 (9), p.1192-1199

2010

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Two Drug Interaction Studies Evaluating the Pharmacokinetics and Toxicity of Pemetrexed When Coadministered with Aspirin or Ibuprofen in Patients with Advanced Cancer

Clinical cancer research, 2006-01, Vol.12 (2), p.536-542

2006

Volltextzugriff (PDF)

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IL‐1β and IL‐18: inflammatory markers or mediators of hypertension?

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt‐induced hypertension in mice

Crystalline structure of pulverized dental calculus induces cell death in oral epithelial cells

NLRP3 inflammasome activation in inflammaging

Getting Closer to the Dirty Little Secret

NLRP3 inflammasomes link inflammation and metabolic disease

Intestinal microbiota modulates susceptibility to acetaminophen induced acute liver injury

Population pharmacokinetic analysis of ten phase II clinical trials of pemetrexed in cancer patients

Phase I and Pharmacokinetic Study of Pemetrexed Administered Every 3 Weeks to Advanced Cancer Patients With Normal and Impaired Renal Function

Targeting the NLRP3 inflammasome in inflammatory diseases

Differential role of NLRP3 inflammasome during acute and chronic cholestatic liver injury

A phase I study of pemetrexed (LY23I5I4) supplemented with folate and vitamin B12 in japanese patients with solid tumours

IFI16 is an innate immune sensor for intracellular DNA

O020 Influenza a virus protein PB1-F2 activates the NLRP3 inflammasome to induce inflammation

Phase I and Pharmacokinetic Study of Pemetrexed with High-Dose Folic Acid Supplementation or Multivitamin Supplementation in Patients with Locally Advanced or Metastatic Cancer

O070 : CX3CR1 is a gatekeeper for intestinal barrier integrity: Limiting steatohepatitis by promoting intestinal homeostasis

A semimechanistic-physiologic population pharmacokinetic/ pharmacodynamic model for neutropenia following pemetrexed therapy

Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment

Clinical application of a semimechanistic-physiologic population PK/PD model for neutropenia following pemetrexed therapy

NOX-free inflammasome activation

Population Pharmacokinetic/Pharmacodynamic Analyses of Pemetrexed and Neutropenia: Effect of Vitamin Supplementation and Differences between Japanese and Western Patients

Phase I and Pharmacokinetic Study of Pemetrexed plus Cisplatin in Chemonaive Patients with Locally Advanced or Metastatic Malignant Pleural Mesothelioma or Non–Small Cell Lung Cancer

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

Two Drug Interaction Studies Evaluating the Pharmacokinetics and Toxicity of Pemetrexed When Coadministered with Aspirin or Ibuprofen in Patients with Advanced Cancer

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