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The past and future of CD33 as therapeutic target in acute myeloid leukemia

Blood reviews, 2014-07, Vol.28 (4), p.143-153

2014

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The Broad Anti-AML Activity of the CD33/CD3 BiTE Antibody Construct, AMG 330, Is Impacted by Disease Stage and Risk

PloS one, 2015-08, Vol.10 (8), p.e0135945-e0135945

2015

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Relationship between CD33 expression, splicing polymorphism, and in vitro cytotoxicity of gemtuzumab ozogamicin and the CD33/CD3 BiTE® AMG 330

Haematologica (Roma), 2019-02, Vol.104 (2), p.e59-e62

2019

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AKT signaling as a novel factor associated with in vitro resistance of human AML to gemtuzumab ozogamicin

PloS one, 2013-01, Vol.8 (1), p.e53518

2013

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Efficient long-term multilineage engraftment of CD33-edited hematopoietic stem/progenitor cells in nonhuman primates

Molecular therapy. Methods & clinical development, 2023-12, Vol.31, p.101121-101121, Article 101121

2023

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Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML

Blood, 2014-01, Vol.123 (4), p.554-561

2014

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Engineering resistance to CD33-targeted immunotherapy in normal hematopoiesis by CRISPR/Cas9-deletion of CD33 exon 2

Leukemia, 2019-03, Vol.33 (3), p.762-808

2019

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Simultaneous multiple interaction T-cell engaging (SMITE) bispecific antibodies overcome bispecific T-cell engager (BiTE) resistance via CD28 co-stimulation

Leukemia, 2018-05, Vol.32 (5), p.1239-1243

2018

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Significance of expression of ITGA5 and its splice variants in acute myeloid leukemia: A report from the children's oncology group

American journal of hematology, 2013-08, Vol.88 (8), p.694-702

2013

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Increased Basal cAMP-dependent Protein Kinase Activity Inhibits the Formation of Mesoderm-derived Structures in the Developing Mouse Embryo

The Journal of biological chemistry, 2002-07, Vol.277 (30), p.27294-27304

2002

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Erratum to: High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse-risk features and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group

Journal of hematology and oncology, 2016-11, Vol.9 (1), p.133-133, Article 133

2016

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Antibody-based therapy of acute myeloid leukemia with gemtuzumab ozogamicin

Frontiers in bioscience, 2013-06, Vol.18 (4), p.1311

2013

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Development of [ 211 At]astatine-based anti-CD123 radioimmunotherapy for acute leukemias and other CD123+ malignancies

Leukemia, 2022-06, Vol.36 (6), p.1485-1491

2022

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The CD33 splice isoform lacking exon 2 as therapeutic target in human acute myeloid leukemia

Leukemia, 2020-09, Vol.34 (9), p.2479-2483

2020

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The Bruton’s tyrosine kinase inhibitor ibrutinib abrogates bispecific antibody‐mediated T‐cell cytotoxicity

British journal of haematology, 2020-04, Vol.189 (1), p.e9-e13

2020

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Targeting the membrane-proximal C2-set domain of CD33 for improved CD33-directed immunotherapy

Leukemia, 2021-09, Vol.35 (9), p.2496-2507

2021

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[211At]astatine-based anti-CD22 radioimmunotherapy for B-cell malignancies

Leukemia & lymphoma, 2023-06, Vol.ahead-of-print (ahead-of-print), p.1-5

2023

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Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation

Journal of cell science, 2014-02, Vol.127 (Pt 3), p.509-520

2014

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Anti-apoptotic BCL-2 family proteins confer resistance to calicheamicin-based antibody-drug conjugate therapy of acute leukemia

Leukemia & lymphoma, 2020-10, Vol.61 (12), p.2990-2994

2020

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Restriction of Src Activity by Cullin-5

Current biology, 2009-01, Vol.19 (2), p.157-162

2009

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Src activation decouples cell division orientation from cell geometry in mammalian cells

Biomaterials, 2018-07, Vol.170, p.82-94

2018

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Expression and functional characterization of CD33 transcript variants in human acute myeloid leukemia

Oncotarget, 2016-07, Vol.7 (28), p.43281-43294

2016

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Src Family Kinase-independent Signal Transduction and Gene Induction by Leukemia Inhibitory Factor

The Journal of biological chemistry, 2003-07, Vol.278 (30), p.27750-27757

2003

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The past and future of CD33 as therapeutic target in acute myeloid leukemia

The Broad Anti-AML Activity of the CD33/CD3 BiTE Antibody Construct, AMG 330, Is Impacted by Disease Stage and Risk

Relationship between CD33 expression, splicing polymorphism, and in vitro cytotoxicity of gemtuzumab ozogamicin and the CD33/CD3 BiTE® AMG 330

Preclinical Characterization of the Anti-Leukemia Activity of the CD33/CD16a/NKG2D Immune-Modulating TriNKET ® CC-96191

AKT signaling as a novel factor associated with in vitro resistance of human AML to gemtuzumab ozogamicin

Efficient long-term multilineage engraftment of CD33-edited hematopoietic stem/progenitor cells in nonhuman primates

Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML

Engineering resistance to CD33-targeted immunotherapy in normal hematopoiesis by CRISPR/Cas9-deletion of CD33 exon 2

Simultaneous multiple interaction T-cell engaging (SMITE) bispecific antibodies overcome bispecific T-cell engager (BiTE) resistance via CD28 co-stimulation

Significance of expression of ITGA5 and its splice variants in acute myeloid leukemia: A report from the children's oncology group

Increased Basal cAMP-dependent Protein Kinase Activity Inhibits the Formation of Mesoderm-derived Structures in the Developing Mouse Embryo

Erratum to: High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse-risk features and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group

Antibody-based therapy of acute myeloid leukemia with gemtuzumab ozogamicin

Development of [ 211 At]astatine-based anti-CD123 radioimmunotherapy for acute leukemias and other CD123+ malignancies

The CD33 splice isoform lacking exon 2 as therapeutic target in human acute myeloid leukemia

The Bruton’s tyrosine kinase inhibitor ibrutinib abrogates bispecific antibody‐mediated T‐cell cytotoxicity

Targeting the membrane-proximal C2-set domain of CD33 for improved CD33-directed immunotherapy

[211At]astatine-based anti-CD22 radioimmunotherapy for B-cell malignancies

Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation

Anti-apoptotic BCL-2 family proteins confer resistance to calicheamicin-based antibody-drug conjugate therapy of acute leukemia

Restriction of Src Activity by Cullin-5

Src activation decouples cell division orientation from cell geometry in mammalian cells

Expression and functional characterization of CD33 transcript variants in human acute myeloid leukemia

COVA4231, a potent CD3/CD33 bispecific FynomAb with IgG-like pharmacokinetics for the treatment of acute myeloid leukemia

Src Family Kinase-independent Signal Transduction and Gene Induction by Leukemia Inhibitory Factor

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