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Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors

European journal of medicinal chemistry, 2018-07, Vol.155, p.316-336

2018

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Design, synthesis, and biological evaluation of new thieno[2,3-d] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling study

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.315-332

2022

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Design, molecular modelling and synthesis of novel benzothiazole derivatives as BCL-2 inhibitors

Scientific reports, 2023-09, Vol.13 (1), p.15554-15554, Article 15554

2023

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Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition

Journal of enzyme inhibition and medicinal chemistry, 2019-01, Vol.34 (1), p.1347-1367

2019

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Covalent EGFR Inhibitors: Binding Mechanisms, Synthetic Approaches, and Clinical Profiles

Archiv der Pharmazie (Weinheim), 2016-08, Vol.349 (8), p.573-593

2016

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Molecular design, synthesis and biological evaluation of novel 1,2,5-trisubstituted benzimidazole derivatives as cytotoxic agents endowed with ABCB1 inhibitory action to overcome multidrug resistance in cancer cells

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.2710-2724

2022

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Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer

European journal of medicinal chemistry, 2019-12, Vol.183, p.111718-111718, Article 111718

2019

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Targeting apoptosis; design, synthesis and biological evaluation of new benzoxazole and thiazole based derivatives

BMC chemistry, 2024-01, Vol.18 (1), p.1-1, Article 1

2024

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Chimeric HDAC inhibitors: Comprehensive review on the HDAC‐based strategies developed to combat cancer

Medicinal research reviews, 2018-11, Vol.38 (6), p.2058-2109

2018

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Design, synthesis and 3D QSAR based pharmacophore study of novel imatinib analogs as antitumor-apoptotic agents

Future medicinal chemistry, 2018-06, Vol.10 (12), p.1421-1433

2018

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A Fluorescence-Based Assay to Probe Inhibitory Effect of Fructose Mimics on GLUT5 Transport in Breast Cancer Cells

ACS bio & med chem au, 2023-02, Vol.3 (1), p.51-61

2023

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Petrology, geochemistry, radioactivity, and M–W type rare earth element tetrads of El Sela altered granites, south eastern desert, Egypt

Acta geochimica, 2019-02, Vol.38 (1), p.95-119

2019

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Clinical and biological factors associated with higher rates of locoregional recurrences in Egyptian patients with early breast cancer

Breast (Edinburgh), 2017-03, Vol.32, p.S128-S128

2017

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Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents

Scientific reports, 2016-04, Vol.6 (1), p.24460, Article 24460

2016

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How to train your inhibitor: Design strategies to overcome resistance to Epidermal Growth Factor Receptor inhibitors

European journal of medicinal chemistry, 2017-12, Vol.142, p.131-151

2017

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Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies

European journal of medicinal chemistry, 2021-10, Vol.221, p.113486, Article 113486

2021

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FLT3-PROTACs for combating AML resistance: Analytical overview on chimeric agents developed, challenges, and future perspectives

European journal of medicinal chemistry, 2024-11, Vol.277, p.116717, Article 116717

2024

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Click and Release: SO2 Prodrugs with Tunable Release Rates

Organic letters, 2017-02, Vol.19 (4), p.818-821

2017

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Montmorillonite Intercalated Norfloxacin and Tobramycin for New Drug-Delivery Systems

Journal of nanoscience and nanotechnology, 2020-08, Vol.20 (8), p.5246-5251

2020

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EP-1191: Concomitant boost versus sequential boost in breast conservative therapy for early stage breast cancer

Radiotherapy and oncology, 2014, Vol.111, p.S52-S52

2014

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Identification of novel furo[2,3- d ]pyrimidine based chalcones as potent anti-breast cancer agents: synthesis, in vitro and in vivo biological evaluation

RSC advances, 2022-03, Vol.12 (13), p.8193-8201

2022

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Synthesis, Characterization, and Evaluation of Cytotoxic Effects of Novel Hybrid Steroidal Heterocycles as PEG Based Nanoparticles

Asian Pacific journal of cancer prevention : APJCP, 2017-07, Vol.18 (7), p.1937-1946

2017

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3D-QSAR pharmacophore modelling, virtual screening and docking studies for lead discovery of a novel scaffold for VEGFR 2 inhibitors: Design, synthesis and biological evaluation

Bioorganic chemistry, 2019-08, Vol.89, p.102988, Article 102988

2019

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Discovery of anilino-furo[2,3-d]pyrimidine derivatives as dual inhibitors of EGFR/HER2 tyrosine kinase and their anticancer activity

European journal of medicinal chemistry, 2018-01, Vol.144, p.330-348

2018

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Novel quinazolinone Derivatives: Design, synthesis and in vivo evaluation as potential agents targeting Alzheimer disease

Bioorganic chemistry, 2024-02, Vol.143, p.107065-107065, Article 107065

2024

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Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors

Design, synthesis, and biological evaluation of new thieno[2,3-d] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling study

Design, molecular modelling and synthesis of novel benzothiazole derivatives as BCL-2 inhibitors

Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition

Covalent EGFR Inhibitors: Binding Mechanisms, Synthetic Approaches, and Clinical Profiles

Molecular design, synthesis and biological evaluation of novel 1,2,5-trisubstituted benzimidazole derivatives as cytotoxic agents endowed with ABCB1 inhibitory action to overcome multidrug resistance in cancer cells

Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer

Targeting apoptosis; design, synthesis and biological evaluation of new benzoxazole and thiazole based derivatives

Chimeric HDAC inhibitors: Comprehensive review on the HDAC‐based strategies developed to combat cancer

Design, synthesis and 3D QSAR based pharmacophore study of novel imatinib analogs as antitumor-apoptotic agents

A Fluorescence-Based Assay to Probe Inhibitory Effect of Fructose Mimics on GLUT5 Transport in Breast Cancer Cells

Petrology, geochemistry, radioactivity, and M–W type rare earth element tetrads of El Sela altered granites, south eastern desert, Egypt

Clinical and biological factors associated with higher rates of locoregional recurrences in Egyptian patients with early breast cancer

Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents

How to train your inhibitor: Design strategies to overcome resistance to Epidermal Growth Factor Receptor inhibitors

Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies

FLT3-PROTACs for combating AML resistance: Analytical overview on chimeric agents developed, challenges, and future perspectives

Click and Release: SO2 Prodrugs with Tunable Release Rates

Montmorillonite Intercalated Norfloxacin and Tobramycin for New Drug-Delivery Systems

EP-1191: Concomitant boost versus sequential boost in breast conservative therapy for early stage breast cancer

Identification of novel furo[2,3- d ]pyrimidine based chalcones as potent anti-breast cancer agents: synthesis, in vitro and in vivo biological evaluation

Synthesis, Characterization, and Evaluation of Cytotoxic Effects of Novel Hybrid Steroidal Heterocycles as PEG Based Nanoparticles

3D-QSAR pharmacophore modelling, virtual screening and docking studies for lead discovery of a novel scaffold for VEGFR 2 inhibitors: Design, synthesis and biological evaluation

Discovery of anilino-furo[2,3-d]pyrimidine derivatives as dual inhibitors of EGFR/HER2 tyrosine kinase and their anticancer activity

Novel quinazolinone Derivatives: Design, synthesis and in vivo evaluation as potential agents targeting Alzheimer disease

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