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Schizophrenia: from dopaminergic to glutamatergic interventions

Current opinion in pharmacology, 2014-02, Vol.14, p.97-102

Laruelle, Marc

2014

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The Second Revision of the Dopamine Theory of Schizophrenia: Implications for Treatment and Drug Development

Biological psychiatry (1969), 2013-07, Vol.74 (2), p.80-81

Laruelle, Marc

2013

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Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited

Journal of cerebral blood flow and metabolism, 2010-01, Vol.30 (1), p.46-50

2010

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Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands

Journal of Cerebral Blood Flow & Metabolism, 2007-09, Vol.27 (9), p.1533-1539

2007

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In vivo quantification of regional dopamine-D3 receptor binding potential of (+)-PHNO: Studies in non-human primates and transgenic mice

Synapse (New York, N.Y.), 2009-09, Vol.63 (9), p.782-793

2009

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Within-subject comparison of [ C]-(+)-PHNO and [ C]raclopride sensitivity to acute amphetamine challenge in healthy humans

Journal of cerebral blood flow and metabolism, 2012-01, Vol.32 (1), p.127-136

2012

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The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction

The international journal of neuropsychopharmacology, 2013-05, Vol.16 (4), p.721-731

2013

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Increased dopamine transmission in schizophrenia: relationship to illness phases

Biological psychiatry (1969), 1999-07, Vol.46 (1), p.56-72

1999

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Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies

Journal of psychopharmacology (Oxford), 1999-07, Vol.13 (4), p.358-371

1999

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Increased baseline occupancy of D2 receptors by dopamine in schizophrenia

Proceedings of the National Academy of Sciences - PNAS, 2000-07, Vol.97 (14), p.8104-8109

2000

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Increased Serotonin 2A Receptor Availability in the Orbitofrontal Cortex of Physically Aggressive Personality Disordered Patients

Biological psychiatry (1969), 2010-06, Vol.67 (12), p.1154-1162

2010

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The role of endogenous sensitization in the pathophysiology of schizophrenia: Implications from recent brain imaging studies

Brain Research Reviews, 2000-03, Vol.31 (2), p.371-384

Laruelle, Marc

2000

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Affinity and selectivity of [11C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo

Synapse (New York, N.Y.), 2012-06, Vol.66 (6), p.489-500

2012

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Combining PET Biodistribution and Equilibrium Dialysis Assays to Assess the Free Brain Concentration and BBB Transport of CNS Drugs

Journal of cerebral blood flow and metabolism, 2012-05, Vol.32 (5), p.874-883

2012

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Impact of D2 Receptor Internalization on Binding Affinity of Neuroimaging Radiotracers

Neuropsychopharmacology (New York, N.Y.), 2010-02, Vol.35 (3), p.806-817

2010

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Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo

Synapse (New York, N.Y.), 2006-12, Vol.60 (7), p.485-495

2006

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Positron emission tomography imaging of amphetamine-induced dopamine release in the human cortex: A comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride

Synapse (New York, N.Y.), 2009-06, Vol.63 (6), p.447-461

2009

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Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy

Journal of cerebral blood flow and metabolism, 2011-03, Vol.31 (3), p.944-952

2011

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Altered Prefrontal Dopaminergic Function in Chronic Recreational Ketamine Users

The American journal of psychiatry, 2005-12, Vol.162 (12), p.2352-2359

2005

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Mechanism of action of antipsychotic drugs : From dopamine D2 receptor antagonism to glutamate NMDA facilitation

Clinical therapeutics, 2005, Vol.27, p.S16-S24

2005

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Imaging the D3 receptor in humans in vivo using [11C](+)-PHNO positron emission tomography (PET)

The international journal of neuropsychopharmacology, 2010-04, Vol.13 (3), p.289-290

2010

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Donepezil impairs memory in healthy older subjects: behavioural, EEG and simultaneous EEG/fMRI biomarkers

PloS one, 2011-09, Vol.6 (9), p.e24126

2011

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Translational characterization of [11C]GSK931145, a PET ligand for the glycine transporter type 1

Synapse (New York, N.Y.), 2011-12, Vol.65 (12), p.1319-1332

2011

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Low Dopamine D2 Receptor Binding Potential in Social Phobia

The American journal of psychiatry, 2000-03, Vol.157 (3), p.457-459

2000

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Characterising the plasma-target occupancy relationship of the neurokinin antagonist GSK1144814 with PET

Journal of psychopharmacology (Oxford), 2014-03, Vol.28 (3), p.244-253

2014

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Schizophrenia: from dopaminergic to glutamatergic interventions

The Second Revision of the Dopamine Theory of Schizophrenia: Implications for Treatment and Drug Development

Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited

Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands

In vivo quantification of regional dopamine-D3 receptor binding potential of (+)-PHNO: Studies in non-human primates and transgenic mice

Within-subject comparison of [ C]-(+)-PHNO and [ C]raclopride sensitivity to acute amphetamine challenge in healthy humans

The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction

Increased dopamine transmission in schizophrenia: relationship to illness phases

Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies

Increased baseline occupancy of D2 receptors by dopamine in schizophrenia

Increased Serotonin 2A Receptor Availability in the Orbitofrontal Cortex of Physically Aggressive Personality Disordered Patients

The role of endogenous sensitization in the pathophysiology of schizophrenia: Implications from recent brain imaging studies

Affinity and selectivity of [11C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo

Combining PET Biodistribution and Equilibrium Dialysis Assays to Assess the Free Brain Concentration and BBB Transport of CNS Drugs

Impact of D2 Receptor Internalization on Binding Affinity of Neuroimaging Radiotracers

Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo

Positron emission tomography imaging of amphetamine-induced dopamine release in the human cortex: A comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride

Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy

Altered Prefrontal Dopaminergic Function in Chronic Recreational Ketamine Users

Mechanism of action of antipsychotic drugs : From dopamine D2 receptor antagonism to glutamate NMDA facilitation

Imaging the D3 receptor in humans in vivo using [11C](+)-PHNO positron emission tomography (PET)

Donepezil impairs memory in healthy older subjects: behavioural, EEG and simultaneous EEG/fMRI biomarkers

Translational characterization of [11C]GSK931145, a PET ligand for the glycine transporter type 1

Low Dopamine D2 Receptor Binding Potential in Social Phobia

Characterising the plasma-target occupancy relationship of the neurokinin antagonist GSK1144814 with PET

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