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Quantification of protein-protein interactions and activation dynamics: A new path to predictive biomarkers

Biophysical chemistry, 2022-04, Vol.283, p.106768-106768, Article 106768

2022

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The unprecedented membrane deformation of the human nuclear envelope, in a magnetic field, indicates formation of nuclear membrane invaginations

Scientific reports, 2020-03, Vol.10 (1), p.5147-5147, Article 5147

2020

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Quantification of biomarker functionality predicts patient outcomes

British journal of cancer, 2021-05, Vol.124 (10), p.1618-1620

2021

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Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition

PLoS biology, 2009-01, Vol.7 (1), p.e17

2009

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The fusion of quantitative molecular proteomics and immune‐oncology: a step towards precision medicine in cancer therapeutics

FEBS letters, 2022-11, Vol.596 (21), p.2721-2735

2022

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Phosphatidylinositol metabolism and membrane fusion

Biochemical journal, 2009-03, Vol.418 (2), p.233-246

2009

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The enigma of phosphoinositides and their derivatives: Their role in regulation of subcellular compartment morphology

Biochimica et biophysica acta. Biomembranes, 2022-02, Vol.1864 (1), p.183780-183780, Article 183780

2022

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Tandem NMR and Mass Spectrometry Analysis of Human Nuclear Membrane Lipids

Analytical chemistry (Washington), 2020-05, Vol.92 (10), p.6858-6868

2020

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HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer

PLoS biology, 2010-12, Vol.8 (12), p.e1000563-e1000563

2010

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Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

PLoS biology, 2007-04, Vol.5 (4), p.e95-791

2007

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Acute depletion of diacylglycerol from the cis-Golgi affects localized nuclear envelope morphology during mitosis

Journal of lipid research, 2018-08, Vol.59 (8), p.1402-1413

2018

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High PD-1/PD-L1 Checkpoint Interaction Infers Tumor Selection and Therapeutic Sensitivity to Anti-PD-1/PD-L1 Treatment

Cancer research (Chicago, Ill.), 2020-10, Vol.80 (19), p.4244-4257

2020

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The PH Domain of Phosphoinositide-Dependent Kinase‑1 Exhibits a Novel, Phospho-Regulated Monomer–Dimer Equilibrium with Important Implications for Kinase Domain Activation: Single-Molecule and Ensemble Studies

Biochemistry (Easton), 2013-07, Vol.52 (28), p.4820-4829

2013

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Determination of Interactive States of Immune Checkpoint Regulators in Lung Metastases after Radiofrequency Ablation

Cancers, 2022-11, Vol.14 (23), p.5738

2022

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Vesicular PtdIns(3,4,5) P 3 and Rab7 are key effectors of sea urchin zygote nuclear membrane fusion

Journal of cell science, 2017-01, Vol.130 (2), p.444-452

2017

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Vesicular PtdIns(3,4,5)P3 and Rab7 are key effectors of sea urchin zygote nuclear membrane fusion

Journal of cell science, 2017-01, Vol.130 (2), p.444-452

2017

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A Complex Interplay of Anionic Phospholipid Binding Regulates 3'-Phosphoinositide-Dependent-Kinase-1 Homodimer Activation

Scientific reports, 2019-10, Vol.9 (1), p.14527-18, Article 14527

2019

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Acute manipulation of diacylglycerol reveals roles in nuclear envelope assembly & endoplasmic reticulum morphology

PloS one, 2012-12, Vol.7 (12), p.e51150

2012

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Acute regulation of PDK1 by a complex interplay of molecular switches

Biochemical Society transactions, 2014-10, Vol.42 (5), p.1435

2014

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HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells

PloS one, 2008-08, Vol.3 (8), p.e2881-e2881

2008

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Regulation of 3-phosphoinositide-dependent protein kinase 1 activity by homodimerization in live cells

Science signaling, 2010-10, Vol.3 (145), p.ra78

2010

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Key role of polyphosphoinositides in dynamics of fusogenic nuclear membrane vesicles

PloS one, 2011-09, Vol.6 (9), p.e23859-e23859

2011

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The Use of Two-Photon FRET-FLIM to Study Protein Interactions During Nuclear Envelope Fusion In Vivo and In Vitro

Methods in molecular biology (Clifton, N.J.), 2016, Vol.1411, p.123

2016

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A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion

Scientific reports, 2016-05, Vol.6 (1), p.26142-26142, Article 26142

2016

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Correction: HER2 Phosphorylation Is Maintained by a PKB Negative Feedback Loop in Response to Anti-HER2 Herceptin in Breast Cancer

PLoS biology, 2016-03, Vol.14 (3), p.e1002414-e1002414

2016

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Quantification of protein-protein interactions and activation dynamics: A new path to predictive biomarkers

The unprecedented membrane deformation of the human nuclear envelope, in a magnetic field, indicates formation of nuclear membrane invaginations

Quantification of biomarker functionality predicts patient outcomes

Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition

The fusion of quantitative molecular proteomics and immune‐oncology: a step towards precision medicine in cancer therapeutics

Phosphatidylinositol metabolism and membrane fusion

The enigma of phosphoinositides and their derivatives: Their role in regulation of subcellular compartment morphology

Tandem NMR and Mass Spectrometry Analysis of Human Nuclear Membrane Lipids

HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer

Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

Acute depletion of diacylglycerol from the cis-Golgi affects localized nuclear envelope morphology during mitosis

High PD-1/PD-L1 Checkpoint Interaction Infers Tumor Selection and Therapeutic Sensitivity to Anti-PD-1/PD-L1 Treatment

The PH Domain of Phosphoinositide-Dependent Kinase‑1 Exhibits a Novel, Phospho-Regulated Monomer–Dimer Equilibrium with Important Implications for Kinase Domain Activation: Single-Molecule and Ensemble Studies

Determination of Interactive States of Immune Checkpoint Regulators in Lung Metastases after Radiofrequency Ablation

Vesicular PtdIns(3,4,5) P 3 and Rab7 are key effectors of sea urchin zygote nuclear membrane fusion

Vesicular PtdIns(3,4,5)P3 and Rab7 are key effectors of sea urchin zygote nuclear membrane fusion

A Complex Interplay of Anionic Phospholipid Binding Regulates 3'-Phosphoinositide-Dependent-Kinase-1 Homodimer Activation

Acute manipulation of diacylglycerol reveals roles in nuclear envelope assembly & endoplasmic reticulum morphology

Acute regulation of PDK1 by a complex interplay of molecular switches

HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells

Regulation of 3-phosphoinositide-dependent protein kinase 1 activity by homodimerization in live cells

Key role of polyphosphoinositides in dynamics of fusogenic nuclear membrane vesicles

The Use of Two-Photon FRET-FLIM to Study Protein Interactions During Nuclear Envelope Fusion In Vivo and In Vitro

A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion

Correction: HER2 Phosphorylation Is Maintained by a PKB Negative Feedback Loop in Response to Anti-HER2 Herceptin in Breast Cancer

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