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Pharmacological characterisation of CR6086, a potent prostaglandin E2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug

Arthritis research & therapy, 2018-03, Vol.20 (1), p.39-39, Article 39

2018

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Modulation of NMDA receptor activity by CR4056, an imidazoline-2 receptor ligand with analgesic properties

Frontiers in pain research (Lausanne, Switzerland), 2022-09, Vol.3, p.1003068-1003068

2022

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Experimental Pharmacology of Glucosamine Sulfate

International Journal of Rheumatology, 2011-01, Vol.2011 (2011), p.174-181

2011

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Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats

British journal of pharmacology, 2014-08, Vol.171 (15), p.3693-3701

2014

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CR4056, a powerful analgesic imidazoline‐2 receptor ligand, inhibits the inflammation‐induced PKCε phosphorylation and membrane translocation in sensory neurons

British journal of pharmacology, 2020-01, Vol.177 (1), p.48-64

2020

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Improved efficacy, tolerance, safety, and abuse liability profile of the combination of CR4056 and morphine over morphine alone in rodent models

British journal of pharmacology, 2020-07, Vol.177 (14), p.3291-3308

2020

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KNOWLEDGE AND VIEWPOINTS ON THE EFFECTS OF CORRUPTION ON HEALTHCARE: A SURVEY CONDUCTED AMONG STUDENTS OF PALERMO UNIVERSITY MEDICAL SCHOOL, ITALY

Euromediterranean biomedical journal, 2018-02, Vol.13 (7), p.31-36

Giuseppe Luigi Marco Lanza

2018

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Pharmacological characterisation of CR6086, a potent prostaglandin E 2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug

Arthritis research & therapy, 2018-03, Vol.20 (1), p.39

2018

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Abstract 2208: Combination of the EP4 antagonist CR6086 and anti-PD-1 monoclonal antibody inhibits tumor growth in a microsatellite stable colorectal cancer in mice

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.2208-2208

2020

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Modulation of imidazoline I sub(2) binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats

British journal of pharmacology, 2014-08, Vol.171 (15), p.3693-3701

2014

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Modulation of imidazoline I 2 binding sites by CR 4056 relieves postoperative hyperalgesia in male and female rats

British journal of pharmacology, 2014-08, Vol.171 (15), p.3693-3701

2014

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Dendrimeric tetravalent ligands for the serotonin-gated ion channel

Chemical communications (Cambridge, England), 2014-08, Vol.50 (62), p.8582-8585

2014

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Efficacy of CR4056, a first-in-class imidazoline-2 analgesic drug, in comparison with naproxen in two rat models of osteoarthritis

Journal of pain research, 2017-01, Vol.10, p.1033-1043

2017

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Synthesis and structure–activity relationship studies in serotonin 5-HT4 receptor ligands based on a benzo[de][2,6]naphthridine scaffold

European journal of medicinal chemistry, 2014-07, Vol.82, p.36-46

2014

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Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds

European journal of medicinal chemistry, 2013-05, Vol.63, p.85-94

2013

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Development of subnanomolar-affinity serotonin 5-HT4 receptor ligands based on quinoline structures

MedChemComm, 2018-09, Vol.9 (9), p.1466-1471

2018

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Development of subnanomolar-affinity serotonin 5-HT4 receptor ligands based on quinoline structuresElectronic supplementary information (ESI) available: Experimental details for the synthesis and the characterization of target compounds and their intermediates. The experimental procedures used in the biological studies. CCDC 1841095 and 1841096. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8md00233a

2018-09

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Development of subnanomolar-affinity serotonin 5-HT 4 receptor ligands based on quinoline structures

MedChemComm, 2018-09, Vol.9 (9), p.1466-1471

2018

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Evaluation of degree of conversion, microtensile bond strength and mechanical properties of three etch-and-rinse dental adhesives

Polímeros, ciência e tecnologia, 2017-09, Vol.27 (3), p.230-236

2017

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Development of subnanomolar-affinity serotonin 5-HT4 receptor ligands based on quinoline structures† †Electronic supplementary information (ESI) available: Experimental details for the synthesis and the characterization of target compounds and their intermediates. The experimental procedures used in the biological studies. CCDC 1841095 and 1841096. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8md00233a

MedChemComm, 2018-07, Vol.9 (9), p.1466-1471

2018

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Biological profile and bioavailability of imidazoline compounds on morphine tolerance modulation

European journal of pharmacology, 2015-12, Vol.769, p.219-224

2015

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Dendrimeric tetravalent ligands for the serotonin-gated ion channelElectronic supplementary information (ESI) available: Experimental details for the synthesis and characterization of target compounds and their intermediates. The experimental procedures used in binding assays. See DOI: 10.1039/c4cc02502d

2014-07

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Multivalent ligands for the serotonin 5-HT4 receptor

MedChemComm, 2017-03, Vol.8 (3), p.647-651

2017

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Multivalent ligands for the serotonin 5-HT4 receptorElectronic supplementary information (ESI) available: Experimental details for the synthesis and characterization of target compounds and their intermediates. The experimental procedures used in the biological studies. See DOI: 10.1039/c6md00458jThe authors declare no competing interests

2017-03

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Multivalent ligands for the serotonin 5-HT 4 receptor

MedChemComm, 2017-03, Vol.8 (3), p.647-651

2017

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Pharmacological characterisation of CR6086, a potent prostaglandin E2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug

Modulation of NMDA receptor activity by CR4056, an imidazoline-2 receptor ligand with analgesic properties

Experimental Pharmacology of Glucosamine Sulfate

Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats

CR4056, a powerful analgesic imidazoline‐2 receptor ligand, inhibits the inflammation‐induced PKCε phosphorylation and membrane translocation in sensory neurons

Improved efficacy, tolerance, safety, and abuse liability profile of the combination of CR4056 and morphine over morphine alone in rodent models

KNOWLEDGE AND VIEWPOINTS ON THE EFFECTS OF CORRUPTION ON HEALTHCARE: A SURVEY CONDUCTED AMONG STUDENTS OF PALERMO UNIVERSITY MEDICAL SCHOOL, ITALY

Pharmacological characterisation of CR6086, a potent prostaglandin E 2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug

Abstract 2208: Combination of the EP4 antagonist CR6086 and anti-PD-1 monoclonal antibody inhibits tumor growth in a microsatellite stable colorectal cancer in mice

Modulation of imidazoline I sub(2) binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats

Modulation of imidazoline I 2 binding sites by CR 4056 relieves postoperative hyperalgesia in male and female rats

Dendrimeric tetravalent ligands for the serotonin-gated ion channel

Efficacy of CR4056, a first-in-class imidazoline-2 analgesic drug, in comparison with naproxen in two rat models of osteoarthritis

Synthesis and structure–activity relationship studies in serotonin 5-HT4 receptor ligands based on a benzo[de][2,6]naphthridine scaffold

Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds

Development of subnanomolar-affinity serotonin 5-HT4 receptor ligands based on quinoline structures

Development of subnanomolar-affinity serotonin 5-HT 4 receptor ligands based on quinoline structures

Evaluation of degree of conversion, microtensile bond strength and mechanical properties of three etch-and-rinse dental adhesives

Biological profile and bioavailability of imidazoline compounds on morphine tolerance modulation

Multivalent ligands for the serotonin 5-HT4 receptor

Multivalent ligands for the serotonin 5-HT 4 receptor

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