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The parkinson's complex: Parkinsonism is just the tip of the iceberg

Annals of neurology, 2006-04, Vol.59 (4), p.591-596

Langston, J. William

2006

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Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease

PLoS genetics, 2011-06, Vol.7 (6), p.e1002141-e1002141

2011

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LRRK2 dephosphorylation increases its ubiquitination

Biochemical journal, 2015-07, Vol.469 (1), p.107-120

2015

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SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress

PloS one, 2011-11, Vol.6 (11), p.e26159-e26159

2011

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LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction

Neurobiology of disease, 2014-02, Vol.62, p.381-386

2014

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The MPTP Story

Journal of Parkinson's disease, 2017-01, Vol.7 (s1), p.S11-S19

Langston, J William

2017

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Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration

Molecular neurodegeneration, 2018-05, Vol.13 (1), p.28-12, Article 28

2018

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Dietary fat intake, pesticide use, and Parkinson's disease

Parkinsonism & related disorders, 2014-01, Vol.20 (1), p.82-87

2014

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Solvent exposures and parkinson disease risk in twins

Annals of neurology, 2012-06, Vol.71 (6), p.776-784

2012

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Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

Neurobiology of disease, 2012-08, Vol.47 (2), p.258-267

2012

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A double-blind, delayed-start trial of rasagiline in Parkinson's disease (the ADAGIO study): prespecified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes

Lancet neurology, 2011-05, Vol.10 (5), p.415-423

2011

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Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication

PloS one, 2014-11, Vol.9 (11), p.e112413-e112413

2014

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Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms

PloS one, 2014-08, Vol.9 (8), p.e102909-e102909

2014

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Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: A biological link between Gaucher disease and parkinsonism

Neurotoxicology (Park Forest South), 2009-11, Vol.30 (6), p.1127-1132

2009

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Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease

PloS one, 2013-08, Vol.8 (8), p.e71634-e71634

2013

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Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease

Toxicology letters, 2011-11, Vol.207 (2), p.97-103

2011

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Nicotine reduces levodopa-induced dyskinesias in lesioned monkeys

Annals of neurology, 2007-12, Vol.62 (6), p.588-596

2007

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Genetic modification of the association of paraquat and Parkinson's disease

Movement disorders, 2012-11, Vol.27 (13), p.1652-1658

2012

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Head injury, alpha-synuclein Rep1, and Parkinson's disease

Annals of neurology, 2012-01, Vol.71 (1), p.40-48

2012

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Loss-of-Function NUBPL Mutation May Link Parkinson's Disease to Recessive Complex I Deficiency

Frontiers in neurology, 2020-10, Vol.11, p.555961-555961

2020

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Heart rate variability in leucine‐rich repeat kinase 2‐associated Parkinson's disease

Movement disorders, 2017-04, Vol.32 (4), p.610-614

2017

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Impact of sustained deprenyl (selegiline) in levodopa-treated Parkinson's disease: A randomized placebo-controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial

Annals of neurology, 2002-05, Vol.51 (5), p.604-612

2002

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Crossroads in GDNF therapy for Parkinson's disease

Movement disorders, 2006-02, Vol.21 (2), p.136-141

2006

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Penetrance of LRRK2 G2385R and R1628P is modified by common PD-associated genetic variants

Parkinsonism & related disorders, 2012-09, Vol.18 (8), p.958-963

2012

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When DLB, PD, and PSP masquerade as MSA: an autopsy study of 134 patients

Neurology, 2015-08, Vol.85 (5), p.404-412

2015

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The parkinson's complex: Parkinsonism is just the tip of the iceberg

Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease

LRRK2 dephosphorylation increases its ubiquitination

SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction

The MPTP Story

Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration

Dietary fat intake, pesticide use, and Parkinson's disease

Solvent exposures and parkinson disease risk in twins

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

A double-blind, delayed-start trial of rasagiline in Parkinson's disease (the ADAGIO study): prespecified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes

Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication

Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms

Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: A biological link between Gaucher disease and parkinsonism

Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease

Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease

Nicotine reduces levodopa-induced dyskinesias in lesioned monkeys

Genetic modification of the association of paraquat and Parkinson's disease

Head injury, alpha-synuclein Rep1, and Parkinson's disease

Loss-of-Function NUBPL Mutation May Link Parkinson's Disease to Recessive Complex I Deficiency

Heart rate variability in leucine‐rich repeat kinase 2‐associated Parkinson's disease

Impact of sustained deprenyl (selegiline) in levodopa-treated Parkinson's disease: A randomized placebo-controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial

Crossroads in GDNF therapy for Parkinson's disease

Penetrance of LRRK2 G2385R and R1628P is modified by common PD-associated genetic variants

When DLB, PD, and PSP masquerade as MSA: an autopsy study of 134 patients

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