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Targeting Neuroinflammation to Treat Alzheimer’s Disease

CNS drugs, 2017-12, Vol.31 (12), p.1057-1082

2017

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Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease

Scientific reports, 2017-02, Vol.7 (1), p.42270-42270, Article 42270

2017

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The extracellular signal-regulated kinase pathway contributes to the control of behavioral excitement

Molecular psychiatry, 2009-04, Vol.14 (4), p.448-461

2009

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Peroxisome proliferator-activated receptor-γ ligands reduce inflammation and infarction size in transient focal ischemia

Neuroscience, 2005, Vol.130 (3), p.685-696

2005

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HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage

Brain, behavior, and immunity, 2018-10, Vol.73, p.670-681

2018

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Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer’s disease

Neurobiology of aging, 2001-11, Vol.22 (6), p.937-944

2001

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Extension of the neuroprotective time window for thiazolidinediones in ischemic stroke is dependent on time of reperfusion

Neuroscience, 2010-10, Vol.170 (3), p.846-857

2010

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Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease

The Journal of neuroscience, 2015-06, Vol.35 (24), p.9173-9181

2015

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Disrupted ERK signaling during cortical development leads to abnormal progenitor proliferation, neuronal and network excitability and behavior, modeling human neuro-cardio-facial-cutaneous and related syndromes

The Journal of neuroscience, 2012-06, Vol.32 (25), p.8663-8677

2012

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Deletion of ERK2 Mitogen-Activated Protein Kinase Identifies Its Key Roles in Cortical Neurogenesis and Cognitive Function

The Journal of neuroscience, 2008-07, Vol.28 (27), p.6983-6995

2008

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S.12.05 Therapeutic use of peroxisome proliferator-activated receptors (PPAR) gamma agonists in the treatment of Alzheimer's disease

European neuropsychopharmacology, 2009, Vol.19, p.S195-S196

Landreth, G

2009

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Protective action of the peroxisome proliferator‐activated receptor‐γ agonist pioglitazone in a mouse model of Parkinson's disease

Journal of neurochemistry, 2002-08, Vol.82 (3), p.615-624

2002

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Identification of the Mechanisms Regulating the Differential Activation of the MAPK Cascade by Epidermal Growth Factor and Nerve Growth Factor in PC12 Cells

The Journal of biological chemistry, 2001-05, Vol.276 (21), p.18169-18177

2001

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Cellular and Molecular Mechanisms of Glial Scarring and Progressive Cavitation: In Vivo and In Vitro Analysis of Inflammation-Induced Secondary Injury after CNS Trauma

The Journal of neuroscience, 1999-10, Vol.19 (19), p.8182-8198

1999

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PPARs in the brain

Biochimica et biophysica acta, 2007-08, Vol.1771 (8), p.1031-1045

2007

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(302) The role of ERK1/2 signaling in the peripheral nervous system

The journal of pain, 2014-04, Vol.15 (4), p.S51-S51

2014

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Altered PPARγ expression and activation after transient focal ischemia in rats

The European journal of neuroscience, 2006-09, Vol.24 (6), p.1653-1663

2006

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Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of beta -Amyloid and Prion Proteins

The Journal of neuroscience, 1999-02, Vol.19 (3), p.928-939

1999

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Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

The Journal of neuroscience, 2012-07, Vol.32 (30), p.10117-10128

2012

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Amyloid Fibrils Activate Tyrosine Kinase-Dependent Signaling and Superoxide Production in Microglia

The Journal of neuroscience, 1997-04, Vol.17 (7), p.2284-2294

1997

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Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning

Learning & memory (Cold Spring Harbor, N.Y.), 2001-01, Vol.8 (1), p.11-19

2001

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beta -Amyloid Fibrils Activate Parallel Mitogen-Activated Protein Kinase Pathways in Microglia and THP1 Monocytes

The Journal of neuroscience, 1998-06, Vol.18 (12), p.4451-4460

1998

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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses

The Journal of neuroscience, 2005-01, Vol.25 (2), p.299-307

2005

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Industrial customer response to wholesale prices in the restructured Texas electricity market

Energy (Oxford), 2007-09, Vol.32 (9), p.1715-1723

2007

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Targeting innate immunity for neurodegenerative disorders of the central nervous system

Journal of neurochemistry, 2016-09, Vol.138 (5), p.653-693

2016

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Targeting Neuroinflammation to Treat Alzheimer’s Disease

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease

The extracellular signal-regulated kinase pathway contributes to the control of behavioral excitement

Peroxisome proliferator-activated receptor-γ ligands reduce inflammation and infarction size in transient focal ischemia

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage

Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer’s disease

Extension of the neuroprotective time window for thiazolidinediones in ischemic stroke is dependent on time of reperfusion

Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease

Disrupted ERK signaling during cortical development leads to abnormal progenitor proliferation, neuronal and network excitability and behavior, modeling human neuro-cardio-facial-cutaneous and related syndromes

Deletion of ERK2 Mitogen-Activated Protein Kinase Identifies Its Key Roles in Cortical Neurogenesis and Cognitive Function

S.12.05 Therapeutic use of peroxisome proliferator-activated receptors (PPAR) gamma agonists in the treatment of Alzheimer's disease

Protective action of the peroxisome proliferator‐activated receptor‐γ agonist pioglitazone in a mouse model of Parkinson's disease

Identification of the Mechanisms Regulating the Differential Activation of the MAPK Cascade by Epidermal Growth Factor and Nerve Growth Factor in PC12 Cells

Cellular and Molecular Mechanisms of Glial Scarring and Progressive Cavitation: In Vivo and In Vitro Analysis of Inflammation-Induced Secondary Injury after CNS Trauma

PPARs in the brain

(302) The role of ERK1/2 signaling in the peripheral nervous system

Altered PPARγ expression and activation after transient focal ischemia in rats

Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of beta -Amyloid and Prion Proteins

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

Amyloid Fibrils Activate Tyrosine Kinase-Dependent Signaling and Superoxide Production in Microglia

Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning

beta -Amyloid Fibrils Activate Parallel Mitogen-Activated Protein Kinase Pathways in Microglia and THP1 Monocytes

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses

Industrial customer response to wholesale prices in the restructured Texas electricity market

Targeting innate immunity for neurodegenerative disorders of the central nervous system

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