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Insulinoma-Associated-1: From Neuroendocrine Tumor Marker to Cancer Therapeutics

Molecular cancer research, 2019-08, Vol.17 (8), p.1597-1604

2019

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Small Molecules Targeting INSM1 for the Treatment of High-Risk Neuroblastoma

Biology (Basel, Switzerland), 2023-08, Vol.12 (8), p.1134

2023

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Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways

International journal of oncology, 2013-03, Vol.42 (3), p.1113-1119

2013

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Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation

The FASEB journal, 2009-07, Vol.23 (7), p.2024-2033

2009

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Interplay: The Essential Role between INSM1 and N-Myc in Aggressive Neuroblastoma

Biology (Basel, Switzerland), 2022-09, Vol.11 (10), p.1376

2022

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INSM1 increases N-myc stability and oncogenesis via a positive-feedback loop in neuroblastoma

Oncotarget, 2015-11, Vol.6 (34), p.36700-36712

2015

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Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells

Developmental biology, 2007-04, Vol.304 (2), p.479-498

2007

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Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance

Journal of translational medicine, 2018-10, Vol.16 (1), p.297-297, Article 297

2018

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A promoter-driven assay for INSM1-associated signaling pathway in neuroblastoma

Cellular signalling, 2020-12, Vol.76, p.109785-109785, Article 109785

2020

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Ectopic expression of a small cell lung cancer transcription factor, INSM1 impairs alveologenesis in lung development

BMC pulmonary medicine, 2016-04, Vol.16 (49), p.49-49, Article 49

2016

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Repurposing a plant alkaloid homoharringtonine targets insulinoma associated-1 in N-Myc-activated neuroblastoma

Cellular signalling, 2023-09, Vol.109, p.110753-110753, Article 110753

2023

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Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest

The Journal of biological chemistry, 2009-02, Vol.284 (9), p.5574-5581

2009

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Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology

Brain research, 2004-10, Vol.1022 (1), p.164-172

2004

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Sonic hedgehog signaling pathway promotes INSM1 transcription factor in neuroendocrine lung cancer

Cellular signalling, 2018-06, Vol.46, p.83-91

2018

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Human CD1D gene expression is regulated by LEF-1 through distal promoter regulatory elements

The Journal of immunology (1950), 2010-05, Vol.184 (9), p.5047-5054

2010

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INSM1 functions as a transcriptional repressor of the neuroD/β2 gene through the recruitment of cyclin D1 and histone deacetylases

Biochemical journal, 2006-07, Vol.397 (1), p.169-177

2006

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NeuroD1/E47 Regulates the E-box Element of a Novel Zinc Finger Transcription Factor, IA-1, in Developing Nervous System

The Journal of biological chemistry, 2003-10, Vol.278 (40), p.38991-38997

2003

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5′-Iodotubercidin represses insulinoma-associated-1 expression, decreases cAMP levels, and suppresses human neuroblastoma cell growth

The Journal of biological chemistry, 2019-04, Vol.294 (14), p.5456-5465

2019

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Targeted Disruption of the Protein Tyrosine Phosphatase-Like Molecule IA-2 Results in Alterations in Glucose Tolerance Tests and Insulin Secretion

Diabetes (New York, N.Y.), 2002-06, Vol.51 (6), p.1842-1850

2002

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Functional Domains of Autoimmune Regulator (AIRE) Modulate INS-VNTR Transcription in Human Thymic Epithelial Cells

The Journal of biological chemistry, 2016-05, Vol.291 (21), p.11313-11322

2016

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Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways

International journal of oncology, 2016-08, p.847

2016

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l-Arginine Regulates the Expression of the T-Cell Receptor ζ Chain (CD3ζ) in Jurkat Cells

Clinical cancer research, 2001-03, Vol.7 (3), p.958s-965s

2001

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Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription

Journal of endocrinology, 2008-07, Vol.198 (1), p.29-39

2008

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Expression of biologically active TAT-fused recombinant islet transcription factors

Life sciences (1973), 2014-09, Vol.114 (1), p.45-50

2014

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Detection of neuroendocrine tumors using promoter-specific secreted Gaussia luciferase

International journal of oncology, 2016-01, Vol.48 (1), p.173-180

2016

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Insulinoma-Associated-1: From Neuroendocrine Tumor Marker to Cancer Therapeutics

Small Molecules Targeting INSM1 for the Treatment of High-Risk Neuroblastoma

Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways

Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation

Interplay: The Essential Role between INSM1 and N-Myc in Aggressive Neuroblastoma

INSM1 increases N-myc stability and oncogenesis via a positive-feedback loop in neuroblastoma

Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells

Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance

A promoter-driven assay for INSM1-associated signaling pathway in neuroblastoma

Ectopic expression of a small cell lung cancer transcription factor, INSM1 impairs alveologenesis in lung development

Repurposing a plant alkaloid homoharringtonine targets insulinoma associated-1 in N-Myc-activated neuroblastoma

Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest

Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology

Sonic hedgehog signaling pathway promotes INSM1 transcription factor in neuroendocrine lung cancer

Human CD1D gene expression is regulated by LEF-1 through distal promoter regulatory elements

INSM1 functions as a transcriptional repressor of the neuroD/β2 gene through the recruitment of cyclin D1 and histone deacetylases

NeuroD1/E47 Regulates the E-box Element of a Novel Zinc Finger Transcription Factor, IA-1, in Developing Nervous System

5′-Iodotubercidin represses insulinoma-associated-1 expression, decreases cAMP levels, and suppresses human neuroblastoma cell growth

Targeted Disruption of the Protein Tyrosine Phosphatase-Like Molecule IA-2 Results in Alterations in Glucose Tolerance Tests and Insulin Secretion

Functional Domains of Autoimmune Regulator (AIRE) Modulate INS-VNTR Transcription in Human Thymic Epithelial Cells

Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways

l-Arginine Regulates the Expression of the T-Cell Receptor ζ Chain (CD3ζ) in Jurkat Cells

Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription

Expression of biologically active TAT-fused recombinant islet transcription factors

Detection of neuroendocrine tumors using promoter-specific secreted Gaussia luciferase

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