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2-Deoxy-d-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion

Cancer chemotherapy and pharmacology, 2011-04, Vol.67 (4), p.899-910

2011

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Antiangiogenic activity of 2-deoxy-D-glucose

PloS one, 2010-10, Vol.5 (10), p.e13699

2010

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Under normoxia, 2-deoxy-d-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation

Molecular cancer therapeutics, 2007-11, Vol.6 (11), p.3049-3058

2007

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2-deoxy-d-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo

Cancer research (Chicago, Ill.), 2004, Vol.64 (1), p.31-34

2004

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The relationship of thioredoxin-1 and cisplatin resistance: its impact on ROS and oxidative metabolism in lung cancer cells

Molecular cancer therapeutics, 2012-03, Vol.11 (3), p.604-615

2012

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Activation of the Unfolded Protein Response by 2-Deoxy-d-Glucose Inhibits Kaposi's Sarcoma-Associated Herpesvirus Replication and Gene Expression

Antimicrobial Agents and Chemotherapy, 2012-11, Vol.56 (11), p.5794-5803

2012

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Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia

Molecular cancer research, 2012-07, Vol.10 (7), p.969-978

2012

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The wonders of 2‐deoxy‐d‐glucose

IUBMB life, 2014-02, Vol.66 (2), p.110-121

2014

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Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions

Cancer chemotherapy and pharmacology, 2004-02, Vol.53 (2), p.116-122

2004

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2‐Deoxy‐d‐glucose exploits increased glucose metabolism in cancer and viral‐infected cells: Relevance to its use in India against SARS‐CoV‐2

IUBMB life, 2021-10, Vol.73 (10), p.1198-1204

2021

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Regulation of Mitochondrial Respiratory Chain Complex Levels, Organization, and Function by Arginyltransferase 1

Frontiers in cell and developmental biology, 2020-12, Vol.8, p.603688-603688

2020

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Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-d-glucose

Molecular cancer therapeutics, 2007-02, Vol.6 (2), p.732-741

2007

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A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

Cancer chemotherapy and pharmacology, 2013-02, Vol.71 (2), p.523-530

2013

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Intrinsically lower AKT, mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-d-glucose under hypoxia in lung cancer cell lines

Molecular cancer therapeutics, 2008-06, Vol.7 (6), p.1506-1513

2008

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Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy

Biochemical pharmacology, 2013-05, Vol.85 (10), p.1463-1477

2013

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Efficacy of 2-halogen substituted D-glucose analogs in blocking glycolysis and killing hypoxic tumor cells

Cancer chemotherapy and pharmacology, 2006-12, Vol.58 (6), p.725-734

2006

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Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C)

Biochemical pharmacology, 2002-12, Vol.64 (12), p.1745-1751

2002

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Targeting the Kynurenine Pathway for the Treatment of Cisplatin-Resistant Lung Cancer

Molecular cancer research, 2020-01, Vol.18 (1), p.105-117

2020

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Differential toxic mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells

Antioxidants & redox signaling, 2007-09, Vol.9 (9), p.1383

2007

Volltextzugriff (PDF)

The evolutionarily conserved arginyltransferase 1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells

Developmental cell, 2022-03, Vol.57 (5), p.654-669.e9

2022

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Targeting cisplatin-resistant human tumor cells with metabolic inhibitors

Cancer chemotherapy and pharmacology, 2014-02, Vol.73 (2), p.417-427

2014

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From delocalized lipophilic cations to hypoxia: Blocking tumor cell mitochondrial function leads to therapeutic gain with glycolytic inhibitors

Molecular nutrition & food research, 2009, Vol.53 (1), p.68-75

2009

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ATF4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2‐deoxyglucose in the same cells

The FEBS journal, 2015-09, Vol.282 (18), p.3647-3658

2015

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Combining 2-deoxy-D-glucose with fenofibrate leads to tumor cell death mediated by simultaneous induction of energy and ER stress

Oncotarget, 2016-06, Vol.7 (24), p.36461-36473

2016

Volltextzugriff (PDF)

Targeting Hypoxia, a Novel Treatment for Advanced Retinoblastoma

Investigative ophthalmology & visual science, 2008-07, Vol.49 (7), p.2799-2805

2008

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2-Deoxy-d-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion

Antiangiogenic activity of 2-deoxy-D-glucose

Under normoxia, 2-deoxy-d-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation

2-deoxy-d-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo

The relationship of thioredoxin-1 and cisplatin resistance: its impact on ROS and oxidative metabolism in lung cancer cells

Activation of the Unfolded Protein Response by 2-Deoxy-d-Glucose Inhibits Kaposi's Sarcoma-Associated Herpesvirus Replication and Gene Expression

Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia

The wonders of 2‐deoxy‐d‐glucose

Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions

2‐Deoxy‐d‐glucose exploits increased glucose metabolism in cancer and viral‐infected cells: Relevance to its use in India against SARS‐CoV‐2

Regulation of Mitochondrial Respiratory Chain Complex Levels, Organization, and Function by Arginyltransferase 1

Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-d-glucose

A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

Intrinsically lower AKT, mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-d-glucose under hypoxia in lung cancer cell lines

Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy

Efficacy of 2-halogen substituted D-glucose analogs in blocking glycolysis and killing hypoxic tumor cells

Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C)

Targeting the Kynurenine Pathway for the Treatment of Cisplatin-Resistant Lung Cancer

Differential toxic mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells

The evolutionarily conserved arginyltransferase 1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells

Targeting cisplatin-resistant human tumor cells with metabolic inhibitors

From delocalized lipophilic cations to hypoxia: Blocking tumor cell mitochondrial function leads to therapeutic gain with glycolytic inhibitors

ATF4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2‐deoxyglucose in the same cells

Combining 2-deoxy-D-glucose with fenofibrate leads to tumor cell death mediated by simultaneous induction of energy and ER stress

Targeting Hypoxia, a Novel Treatment for Advanced Retinoblastoma

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