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The Human Ether-a-go-go-related Gene (hERG) Potassium Channel Represents an Unusual Target for Protease-mediated Damage

The Journal of biological chemistry, 2016-09, Vol.291 (39), p.20387-20401

2016

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The Serum- and Glucocorticoid-inducible Kinases SGK1 and SGK3 Regulate hERG Channel Expression via Ubiquitin Ligase Nedd4-2 and GTPase Rab11

The Journal of biological chemistry, 2013-05, Vol.288 (21), p.15075-15084

2013

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Competition between Slc7a5 and LMAN2 for modulation of Kv1.2 gating

Biophysical journal, 2023-02, Vol.122 (3), p.518a-518a

2023

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Modulation of heteromeric Kv1 channels by transmembrane lectins and redox

Biophysical journal, 2023-02, Vol.122 (3), p.243a-243a

2023

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Unmasking subtype-dependent susceptibility to C-type inactivation in mammalian Kv1 channels

Biophysical journal, 2024-07, Vol.123 (14), p.2012-2023

2024

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Slc7a5 alters Kvβ-mediated regulation of Kv1.2

The Journal of general physiology, 2020-07, Vol.152 (7)

2020

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Modulation of Kv1.2 redox-sensitive gating by the transmembrane lectin LMAN2

Biophysical journal, 2023-02, Vol.122 (3), p.243a-243a

2023

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Heteromeric Assembly of Truncated Neuronal Kv7 Channels: Implications for Neurologic Disease and Pharmacotherapy

Molecular pharmacology, 2020-09, Vol.98 (3), p.192-202

2020

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Glycosylation stabilizes hERG channels on the plasma membrane by decreasing proteolytic susceptibility

The FASEB journal, 2018-04, Vol.32 (4), p.1933-1943

2018

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A structure-based computational workflow to predict liability and binding modes of small molecules to hERG

Scientific reports, 2020-10, Vol.10 (1), p.16262, Article 16262

2020

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Reducing agents facilitate membrane patch seal integrity and longevity

Channels (Austin, Tex.), 2024-12, Vol.18 (1), p.2297621-2297621

2024

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Anti-Ro52 antibody acts on the S5-pore linker of hERG to chronically reduce channel expression

Cardiovascular research, 2019-08, Vol.115 (10), p.1500-1511

2019

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Endoplasmic reticulum stress in the dorsal root ganglia regulates large‐conductance potassium channels and contributes to pain in a model of multiple sclerosis

The FASEB journal, 2020-09, Vol.34 (9), p.12577-12598

2020

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L-type amino acid transporter 1, LAT1, in growth hormone-producing pituitary tumor cells

Molecular and cellular endocrinology, 2020-09, Vol.515, p.110868, Article 110868

2020

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The N terminus and transmembrane segment S1 of Kv1.5 can coassemble with the rest of the channel independently of the S1–S2 linkage

The Journal of biological chemistry, 2018-10, Vol.293 (40), p.15347-15358

2018

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Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels

eLife, 2020-11, Vol.9

2020

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Hypoxia reduces mature hERG channels through calpain up‐regulation

The FASEB journal, 2017-11, Vol.31 (11), p.5068-5077

2017

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Differential Regulation of Human Ether-à-Go-Go-Related Gene (hERG) Current and Expression by Activation of Protein Kinase C

Molecular pharmacology, 2019-07, Vol.96 (1), p.1-12

2019

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Pore- and voltage sensor-targeted KCNQ openers have distinct state-dependent actions

The Journal of general physiology, 2018-12, Vol.150 (12), p.1722-1734

2018

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Rab11-dependent Recycling of the Human Ether-a-go-go-related Gene (hERG) Channel

The Journal of biological chemistry, 2015-08, Vol.290 (34), p.21101-21113

2015

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Febrile temperature facilitates hERG/IKr degradation through an altered K+ dependence

Heart rhythm, 2016-10, Vol.13 (10), p.2004-2011

2016

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Muscarinic receptor activation increases hERG channel expression through phosphorylation of ubiquitin ligase Nedd4-2

Molecular pharmacology, 2014-06, Vol.85 (6), p.877-886

2014

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β -Arrestin-Mediated Regulation of the Human Ether-a-go-go -Related Gene Potassium Channel

Molecular pharmacology, 2017-08, Vol.92 (2), p.162-174

2017

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Site and Mechanism of ML252 Inhibition of Kv7 Voltage-Gated Potassium Channels

Function (Oxford, England), 2023, Vol.4 (4), p.zqad021-zqad021

2023

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Familial neonatal seizures caused by the Kv7.3 selectivity filter mutation T313I

Epilepsia open, 2020-12, Vol.5 (4), p.562-573

2020

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The Human Ether-a-go-go-related Gene (hERG) Potassium Channel Represents an Unusual Target for Protease-mediated Damage

The Serum- and Glucocorticoid-inducible Kinases SGK1 and SGK3 Regulate hERG Channel Expression via Ubiquitin Ligase Nedd4-2 and GTPase Rab11

Competition between Slc7a5 and LMAN2 for modulation of Kv1.2 gating

Modulation of heteromeric Kv1 channels by transmembrane lectins and redox

Unmasking subtype-dependent susceptibility to C-type inactivation in mammalian Kv1 channels

Slc7a5 alters Kvβ-mediated regulation of Kv1.2

Modulation of Kv1.2 redox-sensitive gating by the transmembrane lectin LMAN2

Heteromeric Assembly of Truncated Neuronal Kv7 Channels: Implications for Neurologic Disease and Pharmacotherapy

Glycosylation stabilizes hERG channels on the plasma membrane by decreasing proteolytic susceptibility

A structure-based computational workflow to predict liability and binding modes of small molecules to hERG

Reducing agents facilitate membrane patch seal integrity and longevity

Anti-Ro52 antibody acts on the S5-pore linker of hERG to chronically reduce channel expression

Endoplasmic reticulum stress in the dorsal root ganglia regulates large‐conductance potassium channels and contributes to pain in a model of multiple sclerosis

L-type amino acid transporter 1, LAT1, in growth hormone-producing pituitary tumor cells

The N terminus and transmembrane segment S1 of Kv1.5 can coassemble with the rest of the channel independently of the S1–S2 linkage

Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels

Hypoxia reduces mature hERG channels through calpain up‐regulation

Differential Regulation of Human Ether-à-Go-Go-Related Gene (hERG) Current and Expression by Activation of Protein Kinase C

Pore- and voltage sensor-targeted KCNQ openers have distinct state-dependent actions

Rab11-dependent Recycling of the Human Ether-a-go-go-related Gene (hERG) Channel

Febrile temperature facilitates hERG/IKr degradation through an altered K+ dependence

Muscarinic receptor activation increases hERG channel expression through phosphorylation of ubiquitin ligase Nedd4-2

β -Arrestin-Mediated Regulation of the Human Ether-a-go-go -Related Gene Potassium Channel

Site and Mechanism of ML252 Inhibition of Kv7 Voltage-Gated Potassium Channels

Familial neonatal seizures caused by the Kv7.3 selectivity filter mutation T313I

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