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Development of caspase-3-selective activity-based probes for PET imaging of apoptosis

EJNMMI radiopharmacy and chemistry, 2024-12, Vol.9 (1), p.58-26, Article 58

2024

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Study of the Conformational Dynamics of Prolyl Oligopeptidase by Mass Spectrometry: Lessons Learned

Journal of medicinal chemistry, 2024-06, Vol.67 (12), p.10436-10446

2024

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5‑Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein–Protein Interaction-Derived Functions

Journal of medicinal chemistry, 2024-04, Vol.67 (7), p.5421-5436

2024

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Chemically diverse activity-based probes with unexpected inhibitory mechanisms targeting trypsin-like serine proteases

Frontiers in chemistry, 2023-01, Vol.10, p.1089959-1089959

2023

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The C-terminal cleavage of angiotensin II and III is mediated by prolyl carboxypeptidase in human umbilical vein and aortic endothelial cells

Biochemical pharmacology, 2021-10, Vol.192, p.114738-114738, Article 114738

2021

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Proteolytic Cleavage of Bioactive Peptides and Protease-Activated Receptors in Acute and Post-Colitis

International journal of molecular sciences, 2021-10, Vol.22 (19), p.10711

2021

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Prolyl Carboxypeptidase Mediates the C-Terminal Cleavage of (Pyr)-Apelin-13 in Human Umbilical Vein and Aortic Endothelial Cells

International journal of molecular sciences, 2021-07, Vol.22 (13), p.6698

2021

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The Effect of a Novel Serine Protease Inhibitor on Inflammation and Intestinal Permeability in a Murine Colitis Transfer Model

Frontiers in pharmacology, 2021-06, Vol.12, p.682065-682065

2021

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In Vitro and In Situ Activity-Based Labeling of Fibroblast Activation Protein with UAMC1110-Derived Probes

Frontiers in chemistry, 2021-04, Vol.9, p.640566-640566

2021

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Selective inhibition of carboxypeptidase U may reduce microvascular thrombosis in rat experimental stroke

Journal of thrombosis and haemostasis, 2020-12, Vol.18 (12), p.3325-3335

2020

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Effects of Detergent on α-Synuclein Structure. A Native MS-Ion Mobility Study

International journal of molecular sciences, 2020-10, Vol.21 (21), p.7884

2020

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A novel serine protease inhibitor as potential treatment for dry eye syndrome and ocular inflammation

Scientific reports, 2020-10, Vol.10 (1), p.17268-17268, Article 17268

2020

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Metal ions shape α-synuclein

Scientific reports, 2020-10, Vol.10 (1), p.16293-16293, Article 16293

2020

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Small molecule 3PO inhibits glycolysis but does not bind to 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase‐3 (PFKFB3)

FEBS letters, 2020-09, Vol.594 (18), p.3067-3075

2020

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The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy

Biomedicine & pharmacotherapy, 2020-08, Vol.128, p.110253, Article 110253

2020

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Dysregulated activities of proline-specific enzymes in septic shock patients (sepsis-2)

PloS one, 2020-04, Vol.15 (4), p.e0231555-e0231555

2020

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Efforts towards an On‐Target Version of the Groebke–Blackburn–Bienaymé (GBB) Reaction for Discovery of Druglike Urokinase (uPA) Inhibitors

Chemistry : a European journal, 2019-09, Vol.25 (53), p.12380-12393

2019

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Novel Small Molecule-Derived, Highly Selective Substrates for Fibroblast Activation Protein (FAP)

ACS medicinal chemistry letters, 2019-08, Vol.10 (8), p.1173-1179

2019

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The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma

Clinica chimica acta, 2019-08, Vol.495, p.154-160

2019

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Inhibition of the procarboxypeptidase U (proCPU, TAFI, proCPB2) system due to hemolysis

Journal of thrombosis and haemostasis, 2019-06, Vol.17 (6), p.878-884

2019

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DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages

Life science alliance, 2019-02, Vol.2 (1), p.e201900313

2019

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The reaction between NADPH and mercuric reductase

Flavins and Flavoproteins, 2019, p.509-512

2019

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Vibrational Circular Dichroism Sheds New Light on the Competitive Effects of Crowding and β‑Synuclein on the Fibrillation Process of α‑Synuclein

Biochemistry (Easton), 2018-10, Vol.57 (41), p.5989-5995

2018

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Newly developed serine protease inhibitors decrease visceral hypersensitivity in a post‐inflammatory rat model for irritable bowel syndrome

British journal of pharmacology, 2018-09, Vol.175 (17), p.3516-3533

2018

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Prolyl carboxypeptidase activity in the circulation and its correlation with body weight and adipose tissue in lean and obese subjects

PloS one, 2018-05, Vol.13 (5), p.e0197603-e0197603

2018

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Development of caspase-3-selective activity-based probes for PET imaging of apoptosis

Study of the Conformational Dynamics of Prolyl Oligopeptidase by Mass Spectrometry: Lessons Learned

5‑Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein–Protein Interaction-Derived Functions

Chemically diverse activity-based probes with unexpected inhibitory mechanisms targeting trypsin-like serine proteases

The C-terminal cleavage of angiotensin II and III is mediated by prolyl carboxypeptidase in human umbilical vein and aortic endothelial cells

Proteolytic Cleavage of Bioactive Peptides and Protease-Activated Receptors in Acute and Post-Colitis

Prolyl Carboxypeptidase Mediates the C-Terminal Cleavage of (Pyr)-Apelin-13 in Human Umbilical Vein and Aortic Endothelial Cells

The Effect of a Novel Serine Protease Inhibitor on Inflammation and Intestinal Permeability in a Murine Colitis Transfer Model

In Vitro and In Situ Activity-Based Labeling of Fibroblast Activation Protein with UAMC1110-Derived Probes

Selective inhibition of carboxypeptidase U may reduce microvascular thrombosis in rat experimental stroke

Effects of Detergent on α-Synuclein Structure. A Native MS-Ion Mobility Study

A novel serine protease inhibitor as potential treatment for dry eye syndrome and ocular inflammation

Metal ions shape α-synuclein

Small molecule 3PO inhibits glycolysis but does not bind to 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase‐3 (PFKFB3)

The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy

Dysregulated activities of proline-specific enzymes in septic shock patients (sepsis-2)

Efforts towards an On‐Target Version of the Groebke–Blackburn–Bienaymé (GBB) Reaction for Discovery of Druglike Urokinase (uPA) Inhibitors

Novel Small Molecule-Derived, Highly Selective Substrates for Fibroblast Activation Protein (FAP)

The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma

Inhibition of the procarboxypeptidase U (proCPU, TAFI, proCPB2) system due to hemolysis

DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages

The reaction between NADPH and mercuric reductase

Vibrational Circular Dichroism Sheds New Light on the Competitive Effects of Crowding and β‑Synuclein on the Fibrillation Process of α‑Synuclein

Newly developed serine protease inhibitors decrease visceral hypersensitivity in a post‐inflammatory rat model for irritable bowel syndrome

Prolyl carboxypeptidase activity in the circulation and its correlation with body weight and adipose tissue in lean and obese subjects

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