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A directional switch of integrin signalling and a new anti-thrombotic strategy

Nature (London), 2013-11, Vol.503 (7474), p.131-135

2013

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The P2Y12 Antagonists, 2-Methylthioadenosine 5′-Monophosphate Triethylammonium Salt and Cangrelor (ARC69931MX), Can Inhibit Human Platelet Aggregation through a Gi-independent Increase in cAMP Levels

The Journal of biological chemistry, 2009-06, Vol.284 (24), p.16108-16117

2009

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The Angiogenic Factor Cysteine-Rich 61 (CYR61, CCN1) Supports Vascular Smooth Muscle Cell Adhesion and Stimulates Chemotaxis through Integrin α6β1 and Cell Surface Heparan Sulfate Proteoglycans

Endocrinology (Philadelphia), 2002-04, Vol.143 (4), p.1441-1450

2002

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G Protein Subunit Gα13 Binds to Integrin αIIbβ3 and Mediates Integrin Outside-In Signaling

Science (American Association for the Advancement of Science), 2010-01, Vol.327 (5963), p.340-343

2010

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Localization of an Arg-Gly-Asp Recognition Site within an Integrin Adhesion Receptor

Science (American Association for the Advancement of Science), 1988-10, Vol.242 (4875), p.91-93

1988

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G Protein Subunit G[alpha]13 Binds to Integrin [alpha]IIb[beta]3 and Mediates Integrin "Outside-In" Signaling

Science (American Association for the Advancement of Science), 2010-01, Vol.327 (5963), p.340-343

2010

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The CCN Family of Angiogenic Regulators: The Integrin Connection

Experimental Cell Research, 1999-04, Vol.248 (1), p.44-57

1999

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Identification of integrin αMβ2 as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions

Blood, 2002-06, Vol.99 (12), p.4457-4465

2002

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Identification of a Novel Integrin α6β1 Binding Site in the Angiogenic Inducer CCN1 (CYR61)

The Journal of biological chemistry, 2003-09, Vol.278 (36), p.33801-33808

2003

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Localization of an Integrin Binding Site to the C Terminus of Talin

The Journal of biological chemistry, 2001-11, Vol.276 (48), p.44373-44378

2001

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Adhesion-Induced Unclasping of Cytoplasmic Tails of Integrin αIIbβ3

Biochemistry (Easton), 2009-01, Vol.48 (3), p.617-629

2009

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TA205, an anti-talin monoclonal antibody, inhibits integrin–talin interaction

FEBS letters, 2006-04, Vol.580 (8), p.2027-2032

2006

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Pro-angiogenic Activities of CYR61 (CCN1) Mediated through Integrins αvβ3 and α6β1 in Human Umbilical Vein Endothelial Cells

The Journal of biological chemistry, 2002-11, Vol.277 (48), p.46248-46255

2002

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Targeted Mutagenesis of the Angiogenic Protein CCN1 (CYR61)

The Journal of biological chemistry, 2004-10, Vol.279 (42), p.44177-44187

2004

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Identification of a Novel Integrin αvβ3 Binding Site in CCN1 (CYR61) Critical for Pro-angiogenic Activities in Vascular Endothelial Cells

The Journal of biological chemistry, 2004-10, Vol.279 (42), p.44166-44176

2004

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The role of integrin αDβ2 (CD11d/CD18) in monocyte/macrophage migration

Experimental cell research, 2008-08, Vol.314 (14), p.2569-2578

2008

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A Molecular Basis for Integrin αMβ2 Ligand Binding Promiscuity

The Journal of biological chemistry, 2002-12, Vol.277 (50), p.48635-48642

2002

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CIB1 is an endogenous inhibitor of agonist-induced integrin αIIbβ3 activation

The Journal of cell biology, 2006-01, Vol.172 (2), p.169-175

2006

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The fibrinogen gamma chain dodecapeptide inhibits agonist-induced aggregation of rabbit platelets and fibrinogen binding to rabbit glycoprotein IIb-IIIa

Thrombosis and haemostasis, 1999-12, Vol.82 (6), p.1680

1999

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Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions

Blood, 2002-06, Vol.99 (12), p.4457-4465

2002

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Identification of a Novel Integrin αMβ2 Binding Site in CCN1 (CYR61), a Matricellular Protein Expressed in Healing Wounds and Atherosclerotic Lesions

The Journal of biological chemistry, 2003-07, Vol.278 (28), p.25808-25815

2003

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The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans

Endocrinology (Philadelphia), 2002-04, Vol.143 (4), p.1441-1450

2002

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Critical roles for the COOH-terminal NITY and RGT sequences of the integrin β3 cytoplasmic domain in inside-out and outside-in signaling

The Journal of cell biology, 2003-07, Vol.162 (2), p.329-339

2003

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A Mechanism For Switch Of Integrin Signaling Direction and a New Anti-Thrombotic Strategy Through Selective Outside-In Signaling Inhibition

Blood, 2013-11, Vol.122 (21), p.2295-2295

2013

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Identification of a Talin-binding Site in the Integrin β3 Subunit Distinct from the NPLY Regulatory Motif of Post-ligand Binding Functions

The Journal of biological chemistry, 1999-10, Vol.274 (40), p.28575-28583

1999

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A directional switch of integrin signalling and a new anti-thrombotic strategy

The P2Y12 Antagonists, 2-Methylthioadenosine 5′-Monophosphate Triethylammonium Salt and Cangrelor (ARC69931MX), Can Inhibit Human Platelet Aggregation through a Gi-independent Increase in cAMP Levels

The Angiogenic Factor Cysteine-Rich 61 (CYR61, CCN1) Supports Vascular Smooth Muscle Cell Adhesion and Stimulates Chemotaxis through Integrin α6β1 and Cell Surface Heparan Sulfate Proteoglycans

G Protein Subunit Gα13 Binds to Integrin αIIbβ3 and Mediates Integrin Outside-In Signaling

Localization of an Arg-Gly-Asp Recognition Site within an Integrin Adhesion Receptor

G Protein Subunit G[alpha]13 Binds to Integrin [alpha]IIb[beta]3 and Mediates Integrin "Outside-In" Signaling

The CCN Family of Angiogenic Regulators: The Integrin Connection

Identification of integrin αMβ2 as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions

Identification of a Novel Integrin α6β1 Binding Site in the Angiogenic Inducer CCN1 (CYR61)

Localization of an Integrin Binding Site to the C Terminus of Talin

Adhesion-Induced Unclasping of Cytoplasmic Tails of Integrin αIIbβ3

TA205, an anti-talin monoclonal antibody, inhibits integrin–talin interaction

Pro-angiogenic Activities of CYR61 (CCN1) Mediated through Integrins αvβ3 and α6β1 in Human Umbilical Vein Endothelial Cells

Targeted Mutagenesis of the Angiogenic Protein CCN1 (CYR61)

Identification of a Novel Integrin αvβ3 Binding Site in CCN1 (CYR61) Critical for Pro-angiogenic Activities in Vascular Endothelial Cells

The role of integrin αDβ2 (CD11d/CD18) in monocyte/macrophage migration

A Molecular Basis for Integrin αMβ2 Ligand Binding Promiscuity

CIB1 is an endogenous inhibitor of agonist-induced integrin αIIbβ3 activation

The fibrinogen gamma chain dodecapeptide inhibits agonist-induced aggregation of rabbit platelets and fibrinogen binding to rabbit glycoprotein IIb-IIIa

Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions

Identification of a Novel Integrin αMβ2 Binding Site in CCN1 (CYR61), a Matricellular Protein Expressed in Healing Wounds and Atherosclerotic Lesions

The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans

Critical roles for the COOH-terminal NITY and RGT sequences of the integrin β3 cytoplasmic domain in inside-out and outside-in signaling

A Mechanism For Switch Of Integrin Signaling Direction and a New Anti-Thrombotic Strategy Through Selective Outside-In Signaling Inhibition

Identification of a Talin-binding Site in the Integrin β3 Subunit Distinct from the NPLY Regulatory Motif of Post-ligand Binding Functions

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