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Renal disease in tuberous sclerosis complex: pathogenesis and therapy

Nature reviews. Nephrology, 2018-11, Vol.14 (11), p.704

2018

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Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema

Proceedings of the National Academy of Sciences - PNAS, 2010-11, Vol.107 (44), p.18880-18885

2010

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TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism

Nature communications, 2021-07, Vol.12 (1), p.4245-4245, Article 4245

2021

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TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema

American journal of physiology. Lung cellular and molecular physiology, 2012-11, Vol.303 (9), p.L748-L757

2012

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Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis

Scientific reports, 2018-09, Vol.8 (1), p.14161-10, Article 14161

2018

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Spectrum of germline and somatic mitochondrial DNA variants in Tuberous Sclerosis Complex

Frontiers in genetics, 2023-01, Vol.13, p.917993-917993

2023

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Drug Inhibition of Redox Factor-1 Restores Hypoxia-Driven Changes in Tuberous Sclerosis Complex 2 Deficient Cells

Cancers, 2022-12, Vol.14 (24), p.6195

2022

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New developments in the genetics and pathogenesis of tumours in tuberous sclerosis complex

The Journal of pathology, 2017-01, Vol.241 (2), p.219-225

2017

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nature immunology, 2011-03, Vol.12 (3), p.222

2011

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mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability

Cancer cell, 2017-11, Vol.32 (5), p.624-638.e5

2017

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Deadly triplex: Smoke, autophagy and apoptosis

Autophagy, 2011-04, Vol.7 (4), p.436-437

2011

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Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11

Proceedings of the National Academy of Sciences - PNAS, 2022-07, Vol.119 (28), p.e2122840119-e2122840119

2022

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"Ciliophagy": The consumption of cilia components by autophagy

Autophagy, 2014-03, Vol.10 (3), p.532-534

2014

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TSC2 Interacts with HDLBP/Vigilin and Regulates Stress Granule Formation

Molecular cancer research, 2021-08, Vol.19 (8), p.1389-1397

2021

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Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction

The Journal of clinical investigation, 2013-12, Vol.123 (12), p.5212-5230

2013

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Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells

Proceedings of the National Academy of Sciences - PNAS, 2021-09, Vol.118 (39), p.1

2021

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Protease activity sensors enable real-time treatment response monitoring in lymphangioleiomyomatosis

The European respiratory journal, 2022-04, Vol.59 (4), p.2100664

2022

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Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion

The Journal of experimental medicine, 2019-11, Vol.216 (11), p.2635-2652

2019

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TSC2 regulates microRNA biogenesis via mTORC1 and GSK3β

Human molecular genetics, 2018-05, Vol.27 (9), p.1654-1663

2018

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Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes

Basic research in cardiology, 2024-02, Vol.119 (1), p.151-168

2024

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Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor β (RARβ)

Oncogene, 2019-12, Vol.38 (49), p.7367-7383

2019

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Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization

The American journal of pathology, 2016-12, Vol.186 (12), p.3261-3272

2016

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p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis

Cancer research (Chicago, Ill.), 2017-06, Vol.77 (12), p.3255-3267

2017

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Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction

The Journal of clinical investigation, 2020-11, Vol.130 (11), p.6189-6189

2020

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Renal disease in tuberous sclerosis complex: pathogenesis and therapy

Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema

TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism

TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema

Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis

Spectrum of germline and somatic mitochondrial DNA variants in Tuberous Sclerosis Complex

Drug Inhibition of Redox Factor-1 Restores Hypoxia-Driven Changes in Tuberous Sclerosis Complex 2 Deficient Cells

New developments in the genetics and pathogenesis of tumours in tuberous sclerosis complex

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability

Deadly triplex: Smoke, autophagy and apoptosis

mTORC1 is a mechanosensor that regulates surfactant function and lung compliance during ventilator-induced lung injury

Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11

"Ciliophagy": The consumption of cilia components by autophagy

TSC2 Interacts with HDLBP/Vigilin and Regulates Stress Granule Formation

Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction

Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells

Protease activity sensors enable real-time treatment response monitoring in lymphangioleiomyomatosis

Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion

TSC2 regulates microRNA biogenesis via mTORC1 and GSK3β

Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes

Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor β (RARβ)

Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization

p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis

Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction

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