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Cyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015–2019)

Bioorganic & medicinal chemistry letters, 2019-10, Vol.29 (20), p.126637-126637, Article 126637

2019

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High-Throughput DNA-Encoded Libraries Affinity Selection Platform for Binder Identification with Solid Support Protein Immobilization

Assay and drug development technologies, 2024-06, Vol.22 (4), p.192

2024

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The interaction of p62 with RIP links the atypical PKCs to NF-κB activation

The EMBO journal, 1999-06, Vol.18 (11), p.3044-3053

1999

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Activation of IκB Kinase β by Protein Kinase C Isoforms

Molecular and Cellular Biology, 1999-03, Vol.19 (3), p.2180-2188

1999

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Preclinical characterization of abemaciclib in hormone receptor positive breast cancer

Oncotarget, 2017-09, Vol.8 (41), p.69493-69507

2017

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Splicing Regulation at the Second Catalytic Step by Sex-lethal Involves 3′ Splice Site Recognition by SPF45

Cell, 2002-05, Vol.109 (3), p.285-296

2002

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The N-Terminal 209-aa Domain of High Molecular-Weight 4.1R Isoforms Abrogates 4.1R Targeting to the Nucleus

Proceedings of the National Academy of Sciences - PNAS, 1999-12, Vol.96 (26), p.14925-14930

1999

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Assay Establishment and Validation of a High-Throughput Screening Platform for Three-Dimensional Patient-Derived Colon Cancer Organoid Cultures

Journal of biomolecular screening, 2016-10, Vol.21 (9), p.931-941

2016

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Inactivation of the Inhibitory κB Protein Kinase/Nuclear Factor κB Pathway by Par-4 Expression Potentiates Tumor Necrosis Factor α-induced Apoptosis

The Journal of biological chemistry, 1999-07, Vol.274 (28), p.19606-19612

1999

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TPX2 overexpression promotes sensitivity to dasatinib in breast cancer by activating YAP transcriptional signaling

Molecular oncology, 2024-06, Vol.18 (6), p.1531-1551

2024

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Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability

The EMBO journal, 2001-06, Vol.20 (11), p.2878-2884

2001

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Cyclin dependent kinase (CDK) inhibitors as anticancer drugs

Bioorganic & medicinal chemistry letters, 2015-09, Vol.25 (17), p.3420-3435

2015

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Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

Investigational new drugs, 2014-10, Vol.32 (5), p.825-837

2014

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Continuous treatment with abemaciclib leads to sustained and efficient inhibition of breast cancer cell proliferation

Oncotarget, 2022-07, Vol.13 (1), p.864-875

2022

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Transcription-dependent redistribution of nuclear protein 4.1 to SC35-enriched nuclear domains

Journal of cell science, 1997-01, Vol.110 ( Pt 2) (2), p.239-247

1997

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Multiparametric cell-based assay for the evaluation of transcription inhibition by high-content imaging

Journal of biomolecular screening, 2013-06, Vol.18 (5), p.556-566

2013

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Design, synthesis and validation of a new Crimped Head-Piece for DNA-Encoded libraries generation

Bioorganic & medicinal chemistry, 2024-02, Vol.99, p.117596-117596, Article 117596

2024

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An Alternative Domain Determines Nuclear Localization in Multifunctional Protein 4.1

The Journal of biological chemistry, 1998-05, Vol.273 (19), p.11643-11649

1998

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Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells

Oncotarget, 2020-04, Vol.11 (17), p.1478-1492

2020

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Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy

Molecular cancer therapeutics, 2019-12, Vol.18 (12), p.2207-2219

2019

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Abstract 2829: Preclinical analysis and characterization of abemaciclib using three-dimensional patient-derived colorectal cancer organoid cultures

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.2829-2829

2016

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Phenotypic Screening Approaches to Develop Aurora Kinase Inhibitors: Drug Discovery Perspectives

Frontiers in oncology, 2016-01, Vol.5, p.299-299

2016

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Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy

NPJ breast cancer, 2022-11, Vol.8 (1), p.126-126, Article 126

2022

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Cyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015–2019)

High-Throughput DNA-Encoded Libraries Affinity Selection Platform for Binder Identification with Solid Support Protein Immobilization

The interaction of p62 with RIP links the atypical PKCs to NF-κB activation

Activation of IκB Kinase β by Protein Kinase C Isoforms

Preclinical characterization of abemaciclib in hormone receptor positive breast cancer

Splicing Regulation at the Second Catalytic Step by Sex-lethal Involves 3′ Splice Site Recognition by SPF45

The N-Terminal 209-aa Domain of High Molecular-Weight 4.1R Isoforms Abrogates 4.1R Targeting to the Nucleus

Assay Establishment and Validation of a High-Throughput Screening Platform for Three-Dimensional Patient-Derived Colon Cancer Organoid Cultures

Inactivation of the Inhibitory κB Protein Kinase/Nuclear Factor κB Pathway by Par-4 Expression Potentiates Tumor Necrosis Factor α-induced Apoptosis

TPX2 overexpression promotes sensitivity to dasatinib in breast cancer by activating YAP transcriptional signaling

Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability

Cyclin dependent kinase (CDK) inhibitors as anticancer drugs

Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib

Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene

Continuous treatment with abemaciclib leads to sustained and efficient inhibition of breast cancer cell proliferation

Transcription-dependent redistribution of nuclear protein 4.1 to SC35-enriched nuclear domains

Multiparametric cell-based assay for the evaluation of transcription inhibition by high-content imaging

Design, synthesis and validation of a new Crimped Head-Piece for DNA-Encoded libraries generation

An Alternative Domain Determines Nuclear Localization in Multifunctional Protein 4.1

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells

Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy

Abstract 2829: Preclinical analysis and characterization of abemaciclib using three-dimensional patient-derived colorectal cancer organoid cultures

Phenotypic Screening Approaches to Develop Aurora Kinase Inhibitors: Drug Discovery Perspectives

Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy

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