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The Medicinal Chemistry of Liver X Receptor (LXR) Modulators

Journal of medicinal chemistry, 2014-09, Vol.57 (17), p.7182-7205

2014

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The Hypolipidemic Natural Product Guggulsterone Acts as an Antagonist of the Bile Acid Receptor

Molecular endocrinology (Baltimore, Md.), 2002-07, Vol.16 (7), p.1590-1597

2002

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Activation of the Orphan Nuclear Receptor Steroidogenic Factor 1 by Oxysterols

Proceedings of the National Academy of Sciences - PNAS, 1997-05, Vol.94 (10), p.4895-4900

1997

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Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists

Bioorganic & medicinal chemistry, 2016-03, Vol.24 (6), p.1384-1391

2016

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Repression of p65 Transcriptional Activation by the Glucocorticoid Receptor in the Absence of Receptor-Coactivator Interactions

Molecular endocrinology (Baltimore, Md.), 2004-01, Vol.18 (1), p.53-62

2004

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Pharmacological characterization of the selective 11β-hydroxysteroid dehydrogenase 1 inhibitor, BI 135585, a clinical candidate for the treatment of type 2 diabetes

European journal of pharmacology, 2015-01, Vol.746, p.50-55

2015

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Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors

Molecular pharmacology, 2012-10, Vol.82 (4), p.719-727

2012

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Activation of specific RXR heterodimers by an antagonist of RXR homodimers

Nature (London), 1996-10, Vol.383 (6599), p.450-453

1996

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Influence of sub-chronic selective 11β-hydroxysteroid dehydrogenase 1 inhibition on the hypothalamic-pituitary-adrenal axis in female cynomolgus monkeys

European journal of pharmacology, 2016-10, Vol.789, p.68-74

2016

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Liver X Receptors Interact with Corepressors to Regulate Gene Expression

Molecular endocrinology (Baltimore, Md.), 2003-06, Vol.17 (6), p.1019-1026

2003

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The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor

Molecular endocrinology (Baltimore, Md.), 2002-07, Vol.16 (7), p.1590

2002

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Effects of the bace1 inhibitor bi 1181181 and the anti-abeta antibody m266 on abeta in rat brain homogenate and CSF

Alzheimer's & dementia, 2015-07, Vol.11 (7), p.P843-P843

2015

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An activin receptor-like kinase 5 inhibitor reduces collagen deposition in a rat dermal incision wound healing model

Plastic and reconstructive surgery (1963), 2011-11, Vol.128 (5), p.451e-459e

2011

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Pharmacological characterization of the new bace1 inhibitor bi 1181181

Alzheimer's & dementia, 2015-07, Vol.11 (7), p.P477-P477

2015

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The Ligand-Dependent Interaction of Mineralocorticoid Receptor with Coactivator and Corepressor Peptides Suggests Multiple Activation Mechanisms

Molecular endocrinology (Baltimore, Md.), 2005-06, Vol.19 (6), p.1460-1473

2005

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Multiplexing nuclear receptors for agonist identification in a cell-based reporter gene high-throughput screen

Journal of biomolecular screening, 2003-06, Vol.8 (3), p.239-246

2003

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Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring

Bioorganic & medicinal chemistry letters, 2012-05, Vol.22 (10), p.3392-3397

2012

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Steroidogenic factor 1: an essential mediator of endocrine development

Recent progress in hormone research, 2002, Vol.57 (1), p.19-36

2002

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The liver X receptors

Current opinion in investigational drugs (London, England : 2000), 2005-09, Vol.6 (9), p.934

Lala, Deepak S

2005

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Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone

Mini reviews in medicinal chemistry, 2005-08, Vol.5 (8), p.709-718

2005

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The Rexinoid LG100754 Is a Novel RXR:PPARγ Agonist and Decreases Glucose Levels in Vivo

Molecular endocrinology (Baltimore, Md.), 2001-08, Vol.15 (8), p.1360-1369

2001

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Abstract 334: The LXRβ Selective Agonist, VTP-38443, Significantly Decreases Plaque Cholesterol Ester Content and Inflammation in a Murine Model of Accelerated Atherosclerosis

Arteriosclerosis, thrombosis, and vascular biology, 2015-05, Vol.35 (suppl_1)

2015

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Safety, tolerability, pharmacokinetics and pharmacodynamics of VTP-43742, a RORγt inhibitor, in normal healthy volunteers

The Journal of immunology (1950), 2016-05, Vol.196 (1_Supplement), p.71-71.4

2016

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Induction of Human Liver X Receptor α Gene Expression Via an Autoregulatory Loop Mechanism

Molecular endocrinology (Baltimore, Md.), 2002-03, Vol.16 (3), p.506-514

2002

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P4‐168: Effects of the bace1 inhibitor bi 1181181 and the anti‐abeta antibody m266 on abeta in rat brain homogenate and CSF

Alzheimer's & dementia, 2015-07, Vol.11 (7S_Part_18), p.P843-P843

2015

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The Medicinal Chemistry of Liver X Receptor (LXR) Modulators

The Hypolipidemic Natural Product Guggulsterone Acts as an Antagonist of the Bile Acid Receptor

Activation of the Orphan Nuclear Receptor Steroidogenic Factor 1 by Oxysterols

Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists

Repression of p65 Transcriptional Activation by the Glucocorticoid Receptor in the Absence of Receptor-Coactivator Interactions

Pharmacological characterization of the selective 11β-hydroxysteroid dehydrogenase 1 inhibitor, BI 135585, a clinical candidate for the treatment of type 2 diabetes

Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors

Activation of specific RXR heterodimers by an antagonist of RXR homodimers

Influence of sub-chronic selective 11β-hydroxysteroid dehydrogenase 1 inhibition on the hypothalamic-pituitary-adrenal axis in female cynomolgus monkeys

Liver X Receptors Interact with Corepressors to Regulate Gene Expression

The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor

Effects of the bace1 inhibitor bi 1181181 and the anti-abeta antibody m266 on abeta in rat brain homogenate and CSF

An activin receptor-like kinase 5 inhibitor reduces collagen deposition in a rat dermal incision wound healing model

Pharmacological characterization of the new bace1 inhibitor bi 1181181

The Ligand-Dependent Interaction of Mineralocorticoid Receptor with Coactivator and Corepressor Peptides Suggests Multiple Activation Mechanisms

Multiplexing nuclear receptors for agonist identification in a cell-based reporter gene high-throughput screen

Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring

Steroidogenic factor 1: an essential mediator of endocrine development

The liver X receptors

Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone

The Rexinoid LG100754 Is a Novel RXR:PPARγ Agonist and Decreases Glucose Levels in Vivo

Abstract 334: The LXRβ Selective Agonist, VTP-38443, Significantly Decreases Plaque Cholesterol Ester Content and Inflammation in a Murine Model of Accelerated Atherosclerosis

Safety, tolerability, pharmacokinetics and pharmacodynamics of VTP-43742, a RORγt inhibitor, in normal healthy volunteers

Induction of Human Liver X Receptor α Gene Expression Via an Autoregulatory Loop Mechanism

P4‐168: Effects of the bace1 inhibitor bi 1181181 and the anti‐abeta antibody m266 on abeta in rat brain homogenate and CSF

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