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The Medicinal Chemistry of Liver X Receptor (LXR) Modulators

Journal of medicinal chemistry, 2014-09, Vol.57 (17), p.7182-7205

2014

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Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists

Bioorganic & medicinal chemistry, 2016-03, Vol.24 (6), p.1384-1391

2016

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The Hypolipidemic Natural Product Guggulsterone Acts as an Antagonist of the Bile Acid Receptor

Molecular endocrinology (Baltimore, Md.), 2002-07, Vol.16 (7), p.1590-1597

2002

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Pharmacological characterization of the selective 11β-hydroxysteroid dehydrogenase 1 inhibitor, BI 135585, a clinical candidate for the treatment of type 2 diabetes

European journal of pharmacology, 2015-01, Vol.746, p.50-55

2015

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Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors

Molecular pharmacology, 2012-10, Vol.82 (4), p.719-727

2012

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Influence of sub-chronic selective 11β-hydroxysteroid dehydrogenase 1 inhibition on the hypothalamic-pituitary-adrenal axis in female cynomolgus monkeys

European journal of pharmacology, 2016-10, Vol.789, p.68-74

2016

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Abstract 2625: Identification of CTX-30916 as a novel antagonist of progesterone receptor signaling pathways

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.2625-2625

2019

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Personalization of cancer treatment using predictive simulation

Journal of translational medicine, 2015-02, Vol.13 (1), p.43-43

2015

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Liver X Receptors Interact with Corepressors to Regulate Gene Expression

Molecular endocrinology (Baltimore, Md.), 2003-06, Vol.17 (6), p.1019-1026

2003

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The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor

Molecular endocrinology (Baltimore, Md.), 2002-07, Vol.16 (7), p.1590

2002

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Effects of the bace1 inhibitor bi 1181181 and the anti-abeta antibody m266 on abeta in rat brain homogenate and CSF

Alzheimer's & dementia, 2015-07, Vol.11 (7), p.P843-P843

2015

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An activin receptor-like kinase 5 inhibitor reduces collagen deposition in a rat dermal incision wound healing model

Plastic and reconstructive surgery (1963), 2011-11, Vol.128 (5), p.451e-459e

2011

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Pharmacological characterization of the new bace1 inhibitor bi 1181181

Alzheimer's & dementia, 2015-07, Vol.11 (7), p.P477-P477

2015

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The Ligand-Dependent Interaction of Mineralocorticoid Receptor with Coactivator and Corepressor Peptides Suggests Multiple Activation Mechanisms

Molecular endocrinology (Baltimore, Md.), 2005-06, Vol.19 (6), p.1460-1473

2005

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Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone

Mini reviews in medicinal chemistry, 2005-08, Vol.5 (8), p.709-718

2005

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Activation of the Orphan Nuclear Receptor Steroidogenic Factor 1 by Oxysterols

Proceedings of the National Academy of Sciences - PNAS, 1997-05, Vol.94 (10), p.4895-4900

1997

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Repression of p65 Transcriptional Activation by the Glucocorticoid Receptor in the Absence of Receptor-Coactivator Interactions

Molecular endocrinology (Baltimore, Md.), 2004-01, Vol.18 (1), p.53-62

2004

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Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring

Bioorganic & medicinal chemistry letters, 2012-05, Vol.22 (10), p.3392-3397

2012

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Steroidogenic factor 1: an essential mediator of endocrine development

Recent progress in hormone research, 2002, Vol.57 (1), p.19-36

2002

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Activation of specific RXR heterodimers by an antagonist of RXR homodimers

Nature (London), 1996-10, Vol.383 (6599), p.450-453

1996

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The liver X receptors

Current opinion in investigational drugs (London, England : 2000), 2005-09, Vol.6 (9), p.934

Lala, Deepak S

2005

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Predicting Resistance to the Combination of ATO and ATRA in APL Patients with PML-Rara Fusions, Using a Computational Biology Modeling Approach: Mycare-021-01

Blood, 2020-11, Vol.136 (Supplement 1), p.31-32

2020

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Comparative Analysis for Differential Drug Response between Early T-Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) and T-Cell Acute Lymphoblastic Leukemia (T-ALL) Patients Using the Cellworks Omics Biology Model (CBM): Mycare-021-03

Blood, 2020-11, Vol.136 (Supplement 1), p.18-19

2020

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The Medicinal Chemistry of Liver X Receptor (LXR) Modulators

Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists

The Hypolipidemic Natural Product Guggulsterone Acts as an Antagonist of the Bile Acid Receptor

Pharmacological characterization of the selective 11β-hydroxysteroid dehydrogenase 1 inhibitor, BI 135585, a clinical candidate for the treatment of type 2 diabetes

Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors

Influence of sub-chronic selective 11β-hydroxysteroid dehydrogenase 1 inhibition on the hypothalamic-pituitary-adrenal axis in female cynomolgus monkeys

Abstract 2625: Identification of CTX-30916 as a novel antagonist of progesterone receptor signaling pathways

Personalization of cancer treatment using predictive simulation

Liver X Receptors Interact with Corepressors to Regulate Gene Expression

The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor

Effects of the bace1 inhibitor bi 1181181 and the anti-abeta antibody m266 on abeta in rat brain homogenate and CSF

An activin receptor-like kinase 5 inhibitor reduces collagen deposition in a rat dermal incision wound healing model

Pharmacological characterization of the new bace1 inhibitor bi 1181181

The Ligand-Dependent Interaction of Mineralocorticoid Receptor with Coactivator and Corepressor Peptides Suggests Multiple Activation Mechanisms

Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone

Activation of the Orphan Nuclear Receptor Steroidogenic Factor 1 by Oxysterols

Repression of p65 Transcriptional Activation by the Glucocorticoid Receptor in the Absence of Receptor-Coactivator Interactions

Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring

Steroidogenic factor 1: an essential mediator of endocrine development

Activation of specific RXR heterodimers by an antagonist of RXR homodimers

The liver X receptors

Predictions of overall survival (OS) and progression-free survival (PFS) for specific therapeutic interventions in newly diagnosed glioblastoma multiforme (GBM) using Cellworks Singula: myCare-024-04

Predicting Resistance to the Combination of ATO and ATRA in APL Patients with PML-Rara Fusions, Using a Computational Biology Modeling Approach: Mycare-021-01

Comparative Analysis for Differential Drug Response between Early T-Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) and T-Cell Acute Lymphoblastic Leukemia (T-ALL) Patients Using the Cellworks Omics Biology Model (CBM): Mycare-021-03

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Identifies Immune Modulation As a Key Pathway for Predicting Azacitidine (AZA) Response in Myelodysplastic Syndromes (MDS)

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