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Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice

Nature medicine, 2020-08, Vol.26 (8), p.1264-1270

2020

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Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1

Nature communications, 2021-02, Vol.12 (1), p.1222-1222, Article 1222

2021

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Crystal structure of a mutant glycosylasparaginase shedding light on aspartylglycosaminurea-causing mechanism as well as on hydrolysis of non-chitobiose substrate

Molecular genetics and metabolism, 2017-04, Vol.121 (2), p.150-156

2017

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Crystal structure of a mutant glycosylasparaginase shedding light on aspartylglycosaminuria-causing mechanism as well as on hydrolysis of non-chitobiose substrate

Molecular genetics and metabolism, 2017-06, Vol.121 (2), p.150-156

2017

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Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells

Bioorganic & medicinal chemistry letters, 2019-09, Vol.29 (17), p.2503-2510

2019

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Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine

Journal of medicinal chemistry, 2018-09, Vol.61 (18), p.8202-8211

2018

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Structural Basis of a Point Mutation that Causes the Genetic Disease Aspartylglucosaminuria

Structure (London), 2014-12, Vol.22 (12), p.1855-1861

2014

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Structural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1

Scientific reports, 2011-12, Vol.1 (1), p.186-186, Article 186

2011

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Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design

Bioorganic & medicinal chemistry letters, 2015-07, Vol.25 (14), p.2818-2823

2015

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Weak dihydrogen bond interactions in organic crystals

Tetrahedron letters, 2004-12, Vol.45 (51), p.9427-9429

2004

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Hydropathy analysis to correlate structure and function of proteins

Biochemical and biophysical research communications, 2004-10, Vol.323 (3), p.996-1002

2004

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First and unexpected synthesis of macrocyclic cyclophane-based unusual α-amino acid derivatives by phosphazene base without high dilution conditions

Bioorganic & medicinal chemistry letters, 2002-04, Vol.12 (7), p.1113-1115

2002

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Optimization of interactions in crystal packing revealed by crystal structures [ethyl 2-(formylamino)-3-thien-2-yl-2-(thien-2-ylmethyl)propanoate and ethyl 3-(5-bromothien-2-yl)-2-[(5-bromothien-2-yl)methyl]-2-(formylamino)propanoate]

Journal of molecular structure, 2004-11, Vol.705 (1), p.101-106

2004

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Synthesis of two new hexaquinanes: advanced C20 precursors to dodecahedrane

Tetrahedron letters, 2002-06, Vol.43 (25), p.4523-4525

2002

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Structure of YqgQ protein from Bacillus subtilis, a conserved hypothetical protein

Acta crystallographica. Section F, Structural biology and crystallization communications, 2010-01, Vol.66 (1), p.8-11

2010

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Synthesis of two new hexaquinanes: advanced C 20 precursors to dodecahedrane

Tetrahedron letters, 2002-06, Vol.43 (25), p.4523-4525

2002

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Conformational switching caused by biphenyl substitution at the C α position: ethyl 2-benzyl-2-(formylamino)-3-phenylpropionate and ethyl 3-(1,1′-biphenyl-4-yl)-2-(formylamino)-2-(4-phenylbenzyl)propionate

Acta crystallographica. Section C, Crystal structure communications, 2004-07, Vol.60 (7), p.o527-o530

2004

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Conformational switching caused by biphenyl substitution at the Cα position: ethyl 2-benzyl-2-(formylamino)-3-phenylpropionate and ethyl 3-(1,1′-biphenyl-4-yl)-2-(formylamino)-2-(4-phenylbenzyl)propionate

Acta crystallographica. Section C, Crystal structure communications, 2004-07, Vol.60 (7), p.o527-o530

2004

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Conformational switching caused by biphenyl substitution at the Calpha position: ethyl 2-benzyl-2-(formylamino)-3-phenylpropionate and ethyl 3-(1,1'-biphenyl-4-yl)-2-(formylamino)-2-(4-phenylbenzyl)propionate

Acta crystallographica. Section C, Crystal structure communications, 2004-07, Vol.60 (Pt 7), p.o527-o530

2004

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Conformational switching caused by biphenyl substitution at the Ca position: ethyl 2-benzyl-2-(formyl-amino)-3-phenylpropionate and ethyl 3-(1,1'-biphenyl-4-yl)-2-formylamino-2-(4-phenylbenzyl)propionate

Acta crystallographica. Section C, Crystal structure communications, 2004, Vol.60, p.o527-o530

2004

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Ethyl 2-formamido-2-(4-iodobenzyl)-3-(4-iodophenyl)propionate and ethyl 2-(3-bromobenzyl)-3-(3-bromo-phenyl)-2-formamidopropionate

Acta crystallographica. Section C, Crystal structure communications, 2003-04, Vol.59 (Pt 4), p.o216-o218

2003

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Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice

Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia

Crystal structure of a mutant glycosylasparaginase shedding light on aspartylglycosaminurea-causing mechanism as well as on hydrolysis of non-chitobiose substrate

Crystal structure of a mutant glycosylasparaginase shedding light on aspartylglycosaminuria-causing mechanism as well as on hydrolysis of non-chitobiose substrate

Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells

Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine

Structural Basis of a Point Mutation that Causes the Genetic Disease Aspartylglucosaminuria

Structural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design

Erratum: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

Weak dihydrogen bond interactions in organic crystals

Hydropathy analysis to correlate structure and function of proteins

First and unexpected synthesis of macrocyclic cyclophane-based unusual α-amino acid derivatives by phosphazene base without high dilution conditions

Optimization of interactions in crystal packing revealed by crystal structures [ethyl 2-(formylamino)-3-thien-2-yl-2-(thien-2-ylmethyl)propanoate and ethyl 3-(5-bromothien-2-yl)-2-[(5-bromothien-2-yl)methyl]-2-(formylamino)propanoate]

Synthesis of two new hexaquinanes: advanced C20 precursors to dodecahedrane

Structure of YqgQ protein from Bacillus subtilis, a conserved hypothetical protein

Synthesis of two new hexaquinanes: advanced C 20 precursors to dodecahedrane

Conformational switching caused by biphenyl substitution at the C α position: ethyl 2-benzyl-2-(formylamino)-3-phenylpropionate and ethyl 3-(1,1′-biphenyl-4-yl)-2-(formylamino)-2-(4-phenylbenzyl)propionate

Conformational switching caused by biphenyl substitution at the Cα position: ethyl 2-benzyl-2-(formylamino)-3-phenylpropionate and ethyl 3-(1,1′-biphenyl-4-yl)-2-(formylamino)-2-(4-phenylbenzyl)propionate

Conformational switching caused by biphenyl substitution at the Calpha position: ethyl 2-benzyl-2-(formylamino)-3-phenylpropionate and ethyl 3-(1,1'-biphenyl-4-yl)-2-(formylamino)-2-(4-phenylbenzyl)propionate

Conformational switching caused by biphenyl substitution at the Ca position: ethyl 2-benzyl-2-(formyl-amino)-3-phenylpropionate and ethyl 3-(1,1'-biphenyl-4-yl)-2-formylamino-2-(4-phenylbenzyl)propionate

Ethyl 2-formamido-2-(4-iodobenzyl)-3-(4-iodophenyl)propionate and ethyl 2-(3-bromobenzyl)-3-(3-bromo-phenyl)-2-formamidopropionate

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