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Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

Critical reviews in toxicology, 2021-05, Vol.51 (5), p.373-394

2021

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Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans

Toxicological sciences, 2020-01, Vol.173 (1), p.86-99

2020

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Involvement of Peroxisome Proliferator-Activated Receptor-Alpha in Liver Tumor Production by Permethrin in the Female Mouse

Toxicological sciences, 2019-04, Vol.168 (2), p.572-596

2019

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Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes

Toxicology (Amsterdam), 2018-03, Vol.396-397, p.23-32

2018

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Induction of drug metabolism: Species differences and toxicological relevance

Toxicology (Amsterdam), 2008-12, Vol.254 (3), p.184-191

2008

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Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin

The Journal of Toxicological Sciences, 2017/12/01, Vol.42(6), pp.773-788

2017

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Editor's Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes

Toxicological sciences, 2017-08, Vol.158 (2), p.412-430

2017

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Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators

Toxicology research (Cambridge), 2018-07, Vol.7 (4), p.697-717

Lake, Brian G

2018

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Evaluation of the utility of the lifetime mouse bioassay in the identification of cancer hazards for humans

Food and chemical toxicology, 2013-10, Vol.60, p.550-562

2013

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Mode-of-action analysis for induction of rat liver tumors by pyrethrins: relevance to human cancer risk

Critical reviews in toxicology, 2009-07, Vol.39 (6), p.501-511

2009

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Lack of effect of metofluthrin and sodium phenobarbital on replicative DNA synthesis and Ki-67 mRNA expression in cultured human hepatocytes

Toxicology research (Cambridge), 2015-01, Vol.4 (4), p.91-913

2015

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Response to Letter to the Editor from Drs. van Kesteren, Pronk, Heusinkveld, Luijten and Hakkert concerning Yamada et al. (2021): Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). Crit. Rev. Toxicol. Vol. 51: 373-394

Critical reviews in toxicology, 2022-05, Vol.52 (5), p.399-402

2022

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Evaluation of the human hazard of the liver and lung tumors in mice treated with permethrin based on mode of action

Critical reviews in toxicology, 2022-01, Vol.52 (1), p.1-31

2022

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Mode of action analysis for fluxapyroxad-induced rat liver tumour formation: evidence for activation of the constitutive androstane receptor and assessment of human relevance

Toxicology (Amsterdam), 2024-06, Vol.505, p.153828-153828, Article 153828

2024

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Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes

Toxicology (Amsterdam), 2009-04, Vol.258 (1), p.64-69

2009

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Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver

Toxicological sciences, 2014-11, Vol.142 (1), p.137-157

2014

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Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes

Drug metabolism and disposition, 2001-08, Vol.29 (8), p.1146

2001

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Comparison of the Hepatic Effects of Phenobarbital in Chimeric Mice Containing Either Rat or Human Hepatocytes With Humanized Constitutive Androstane Receptor and Pregnane X Receptor Mice

Toxicological sciences, 2020-10, Vol.177 (2), p.362-376

2020

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An Evaluation of the Human Relevance of the Liver Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action

Toxicological sciences, 2020-05, Vol.175 (1), p.50-63

2020

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Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

Critical reviews in toxicology, 2014-01, Vol.44 (1), p.64-82

2014

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Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance

Pharmaceutical research, 2006-03, Vol.23 (3), p.533-539

2006

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Comparative studies on the effects of sodium phenobarbital and two other constitutive androstane receptor (CAR) activators on induction of cytochrome P450 enzymes and replicative DNA synthesis in cultured hepatocytes from wild type and CAR knockout rats

Toxicology (Amsterdam), 2020-03, Vol.433-434, p.152394, Article 152394

2020

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Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital

Toxicology (Amsterdam), 2020-01, Vol.430, p.152343, Article 152343

2020

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Metabolism of deltamethrin and cis- and trans-permethrin by rat and human liver microsomes, liver cytosol and plasma preparations

Xenobiotica, 2019-04, Vol.49 (4), p.388-396

2019

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Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance

Toxicology (Amsterdam), 2020-06, Vol.439, p.152465, Article 152465

2020

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Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans

Involvement of Peroxisome Proliferator-Activated Receptor-Alpha in Liver Tumor Production by Permethrin in the Female Mouse

Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes

Induction of drug metabolism: Species differences and toxicological relevance

Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin

Editor's Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes

Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators

Evaluation of the utility of the lifetime mouse bioassay in the identification of cancer hazards for humans

Mode-of-action analysis for induction of rat liver tumors by pyrethrins: relevance to human cancer risk

Lack of effect of metofluthrin and sodium phenobarbital on replicative DNA synthesis and Ki-67 mRNA expression in cultured human hepatocytes

Evaluation of the human hazard of the liver and lung tumors in mice treated with permethrin based on mode of action

Mode of action analysis for fluxapyroxad-induced rat liver tumour formation: evidence for activation of the constitutive androstane receptor and assessment of human relevance

Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes

Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver

Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes

Comparison of the Hepatic Effects of Phenobarbital in Chimeric Mice Containing Either Rat or Human Hepatocytes With Humanized Constitutive Androstane Receptor and Pregnane X Receptor Mice

An Evaluation of the Human Relevance of the Liver Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action

Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance

Comparative studies on the effects of sodium phenobarbital and two other constitutive androstane receptor (CAR) activators on induction of cytochrome P450 enzymes and replicative DNA synthesis in cultured hepatocytes from wild type and CAR knockout rats

Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital

Metabolism of deltamethrin and cis- and trans-permethrin by rat and human liver microsomes, liver cytosol and plasma preparations

Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance

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