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Coumarin Metabolism, Toxicity and Carcinogenicity: Relevance for Human Risk Assessment

Food and Chemical Toxicology, 1999-04, Vol.37 (4), p.423-453

Lake, B.G

1999

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Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation

Xenobiotica, 2009-08, Vol.39 (8), p.582-596

Lake, B. G.

2009

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Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices

Xenobiotica, 2003-05, Vol.33 (5), p.511-527

2003

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Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes

Drug metabolism and disposition, 2001-08, Vol.29 (8), p.1146

2001

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Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase

Xenobiotica, 2002-10, Vol.32 (10), p.835-847

2002

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A Cancer Risk Assessment of Di(2-ethylhexyl)phthalate: Application of the New U.S. EPA Risk Assessment Guidelines

Regulatory toxicology and pharmacology, 1999-06, Vol.29 (3), p.327-357

1999

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Evolution of the cytochrome P450 superfamily: sequence alignments and pharmacogenetics

Mutation research, 1998-06, Vol.410 (3), p.245-270

1998

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Mechanisms of hepatocarcinogenicity of peroxisome-proliferating drugs and chemicals

Annual review of pharmacology and toxicology, 1995-01, Vol.35 (1), p.483-507

Lake, B G

1995

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Induction of drug metabolism: Species differences and toxicological relevance

Toxicology (Amsterdam), 2008-12, Vol.254 (3), p.184-191

2008

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Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes

Xenobiotica, 2008-06, Vol.38 (6), p.574-586

2008

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Inhibition of zaleplon metabolism by cimetidine in the human liver: in vitro studies with subcellular fractions and precision-cut liver slices

Xenobiotica, 2002-10, Vol.32 (10), p.849-862

2002

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Quantitative structure–activity relationships for inducers of cytochromes P450 and nuclear receptor ligands involved in P450 regulation within the CYP1, CYP2, CYP3 and CYP4 families

Toxicology (Amsterdam), 2002-07, Vol.176 (1), p.51-57

2002

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Homology modelling of human CYP2E1 based on the CYP2C5 crystal structure: investigation of enzyme–substrate and enzyme–inhibitor interactions

Toxicology in vitro, 2003-02, Vol.17 (1), p.93-105

2003

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Studies on the disposition, metabolism and hepatotoxicity of coumarin in the rat and Syrian hamster

Food and chemical toxicology, 2002-06, Vol.40 (6), p.809-823

2002

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Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard to Humans?

Regulatory toxicology and pharmacology, 1998-02, Vol.27 (1), p.47-60

1998

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Homology modelling of human CYP1A2 based on the CYP2C5 crystallographic template structure

Xenobiotica, 2003-03, Vol.33 (3), p.239-254

2003

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Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver

Toxicology (Amsterdam), 1998-11, Vol.131 (1), p.9-20

1998

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Homology modelling of CYP2A6 based on the CYP2C5 crystallographic template: enzyme–substrate interactions and QSARs for binding affinity and inhibition

Toxicology in vitro, 2003-04, Vol.17 (2), p.179-190

2003

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Carbamazepine: a 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems

Xenobiotica, 2001, Vol.31 (6), p.321-343

2001

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Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform

Xenobiotica, 2000, Vol.30 (1), p.1-25

2000

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Metabolism of Zaleplon by human hepatic microsomal cytochrome P450 isoforms

Xenobiotica, 1998, Vol.28 (4), p.337-348

1998

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Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity

Toxicology (Amsterdam), 1999-03, Vol.133 (1), p.1-33

1999

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Expression and alternative splicing of the cytochrome P-450 CYP2A7

Biochemical journal, 1995-02, Vol.306 ( Pt 1) (1), p.161-166

1995

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Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions

Xenobiotica, 2002-07, Vol.32 (7), p.547-561

2002

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Molecular modelling of CYP1A subfamily members based on an alignment with CYP102: rationalization of CYP1A substrate specificity in terms of active site amino acid residues

Xenobiotica, 1996-07, Vol.26 (7), p.723-753

1996

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Coumarin Metabolism, Toxicity and Carcinogenicity: Relevance for Human Risk Assessment

Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation

Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices

Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes

Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase

A Cancer Risk Assessment of Di(2-ethylhexyl)phthalate: Application of the New U.S. EPA Risk Assessment Guidelines

Evolution of the cytochrome P450 superfamily: sequence alignments and pharmacogenetics

Mechanisms of hepatocarcinogenicity of peroxisome-proliferating drugs and chemicals

Induction of drug metabolism: Species differences and toxicological relevance

Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes

Inhibition of zaleplon metabolism by cimetidine in the human liver: in vitro studies with subcellular fractions and precision-cut liver slices

Quantitative structure–activity relationships for inducers of cytochromes P450 and nuclear receptor ligands involved in P450 regulation within the CYP1, CYP2, CYP3 and CYP4 families

Homology modelling of human CYP2E1 based on the CYP2C5 crystal structure: investigation of enzyme–substrate and enzyme–inhibitor interactions

Studies on the disposition, metabolism and hepatotoxicity of coumarin in the rat and Syrian hamster

Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard to Humans?

Homology modelling of human CYP1A2 based on the CYP2C5 crystallographic template structure

Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver

Homology modelling of CYP2A6 based on the CYP2C5 crystallographic template: enzyme–substrate interactions and QSARs for binding affinity and inhibition

Carbamazepine: a 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems

Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform

Metabolism of Zaleplon by human hepatic microsomal cytochrome P450 isoforms

Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity

Expression and alternative splicing of the cytochrome P-450 CYP2A7

Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions

Molecular modelling of CYP1A subfamily members based on an alignment with CYP102: rationalization of CYP1A substrate specificity in terms of active site amino acid residues

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