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3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent

ACS medicinal chemistry letters, 2018-12, Vol.9 (12), p.1164-1169

2018

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Amyloid Structure: Models and Theoretical Considerations in Fibrous Aggregates

Journal of the Chinese Chemical Society (Taipei), 2002-08, Vol.49 (4), p.459-466

2002

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Approaches to target tractability assessment - a practical perspective

MedChemComm, 2018-04, Vol.9 (4), p.606-613

2018

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Approaches to target tractability assessment – a practical perspective† †All authors contributed equally to this perspective

MedChemComm, 2018-02, Vol.9 (4), p.606-613

2018

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Approaches to target tractability assessment - a practical perspectiveAll authors contributed equally to this perspective

2018-04

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The Bioactive Taxol Conformation on β-Tubulin: Experimental Evidence from Highly Active Constrained Analogs

Proceedings of the National Academy of Sciences - PNAS, 2004-07, Vol.101 (27), p.10006-10011

2004

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C-3′-Cyclopropanated Taxol Analogs: Synthesis, Bioassay and Biostructural Analysis

European Journal of Organic Chemistry, 2005-09, Vol.2005 (18), p.3962-3972

2005

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Calculated conformer energies for organic molecules with multiple polar functionalities are method dependent: Taxol (case study)

BMC chemical biology, 2001-10, Vol.1 (1), p.2-2

2001

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Characterization of an exosite binding inhibitor of matrix metalloproteinase 13

Protein science, 2008-01, Vol.17 (1), p.66-71

2008

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ChemInform Abstract: Synthesis and Biological Evaluation of Novel Macrocyclic Paclitaxel Analogues

ChemInform, 2001-11, Vol.32 (46), p.no-no

2001

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Conformational Evolution

Structure (London), 2003-03, Vol.11 (3), p.242

2003

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Conformational Evolution: The Wiggling of Peptides into Amyloid

Structure, 2003-03, Vol.11 (3), p.242-242

2003

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Controlling amyloid growth in multiple dimensions

Amyloid, 2006-12, Vol.13 (4), p.206-215

2006

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Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel

ACS medicinal chemistry letters, 2020-06, Vol.11 (6), p.1353-1353

2020

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Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity

Bioorganic & medicinal chemistry, 2015-11, Vol.23 (21), p.7000-7006

2015

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Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

Cancer research (Chicago, Ill.), 2006-12, Vol.66 (23), p.11100-11105

2006

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Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors

ACS medicinal chemistry letters, 2019-11, Vol.10 (11), p.1518-1523

2019

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Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors

ACS medicinal chemistry letters, 2020-01, Vol.10 (11)

2020

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Druggability Assessment of Allosteric Proteins by Dynamics Simulations in Presence of Probe Molecules

Biophysical journal, 2013-01, Vol.104 (2), p.556a-556a

2013

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Druggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe Molecules

Journal of chemical theory and computation, 2012-07, Vol.8 (7), p.2435-2447

2012

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Dynamics and Fluidity of Amyloid Fibrils: A Model of Fibrous Protein Aggregates

Journal of the American Chemical Society, 2002-12, Vol.124 (51), p.15150-15151

2002

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An Efficient and Highly Diastereoselective Synthesis of GSK1265744, a Potent HIV Integrase Inhibitor

Organic letters, 2015-02, Vol.17 (3), p.564-567

2015

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Evaluation of the Tubulin-Bound Paclitaxel Conformation: Synthesis, Biology, and SAR Studies of C-4 to C-3‘ Bridged Paclitaxel Analogues

Journal of medicinal chemistry, 2007-02, Vol.50 (4), p.713-725

2007

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The Identification and Pharmacological Characterization of 6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4867-4880

2016

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3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent

Amyloid Structure: Models and Theoretical Considerations in Fibrous Aggregates

Approaches to target tractability assessment - a practical perspective

Approaches to target tractability assessment – a practical perspective† †All authors contributed equally to this perspective

Approaches to target tractability assessment - a practical perspectiveAll authors contributed equally to this perspective

The Bioactive Taxol Conformation on β-Tubulin: Experimental Evidence from Highly Active Constrained Analogs

C-3′-Cyclopropanated Taxol Analogs: Synthesis, Bioassay and Biostructural Analysis

Calculated conformer energies for organic molecules with multiple polar functionalities are method dependent: Taxol (case study)

Characterization of an exosite binding inhibitor of matrix metalloproteinase 13

ChemInform Abstract: Synthesis and Biological Evaluation of Novel Macrocyclic Paclitaxel Analogues

Conformational Evolution

Conformational Evolution: The Wiggling of Peptides into Amyloid

Controlling amyloid growth in multiple dimensions

Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel

Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors

Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

Druggability Assessment of Allosteric Proteins by Dynamics Simulations in Presence of Probe Molecules

Druggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe Molecules

Dynamics and Fluidity of Amyloid Fibrils: A Model of Fibrous Protein Aggregates

An Efficient and Highly Diastereoselective Synthesis of GSK1265744, a Potent HIV Integrase Inhibitor

Evaluation of the Tubulin-Bound Paclitaxel Conformation: Synthesis, Biology, and SAR Studies of C-4 to C-3‘ Bridged Paclitaxel Analogues

The Identification and Pharmacological Characterization of 6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase

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