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The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds

Toxicology and applied pharmacology, 2012-09, Vol.263 (2), p.171-183

2012

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Functional assessments in repeat-dose toxicity studies: the art of the possible

Toxicology research (Cambridge), 2013, Vol.2 (4), p.209

2013

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Cardiac imaging approaches to evaluate drug-induced myocardial dysfunction

The American heart journal, 2012-12, Vol.164 (6), p.846-855

2012

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Value of non‐clinical cardiac repolarization assays in supporting the discovery and development of safer medicines

British journal of pharmacology, 2010-01, Vol.159 (1), p.25-33

2010

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Investigation of orthostatic response during telemetry studies: Example with verapamil

Journal of pharmacological and toxicological methods, 2009-09, Vol.60 (2), p.254-255

Lainee, Pierre

2009

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Incidence of cardiac contractility issues in safety pharmacology studies: Is the core battery sufficient?

Journal of pharmacological and toxicological methods, 2009-09, Vol.60 (2), p.252-252

Lainee, Pierre

2009

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Increased lymphoid tissue apoptosis in baboons with bacteremic shock

Shock (Augusta, Ga.), 2004-06, Vol.21 (6), p.566-571

2004

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Activity in Group-Housed Home Cages of Mice as a Novel Preclinical Biomarker in Oncology Studies

Cancers, 2023-09, Vol.15 (19), p.4798

2023

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Delayed neutralization of interferon-γ prevents lethality in primate Gram-negative bacteremic shock

Critical care medicine, 2005-04, Vol.33 (4), p.797-805

2005

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Serotonin receptor blockade improves distal perfusion after lower limb ischemia in the fatty Zucker rat

Cardiovascular research, 2002-11, Vol.56 (2), p.293-302

2002

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Serotonin aggravates exercise-induced cardiac ischemia in the dog: effect of serotonin receptor antagonists

European journal of pharmacology, 2004-08, Vol.497 (1), p.55-63

2004

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Assessment of left ventricular dP/dtmax in telemetry studies: Essential or excessive?

Journal of pharmacological and toxicological methods, 2012-09, Vol.66 (2), p.175-175

2012

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Value of non-clinical cardiac repolarization assays in supporting the discovery and development of safer medicines : QT Safety

British journal of pharmacology, 2010, Vol.159 (1), p.25-33

2010

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A comprehensive assessment of cardiovascular risk in telemetered cynomolgus monkeys

Journal of pharmacological and toxicological methods, 2012-09, Vol.66 (2), p.186-186

2012

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Heart rate dependent potentiation of QRS prolongations can be detected in standard dog telemetry studies

Journal of pharmacological and toxicological methods, 2012-09, Vol.66 (2), p.175-175

2012

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Simultaneous assessment of blood pressure and respiratory function in dogs: Validation of a non-invasive telemetry method

Journal of pharmacological and toxicological methods, 2012-09, Vol.66 (2), p.187-187

2012

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Improving methods for ECG recording in dog toxicology studies: Suggestions based on the review of 100 preclinical projects

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e37-e37

2011

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Cardiac contractility strategy: A case study using early preclinical models

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e29-e29

2011

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The anaesthetised guinea-pig: A suitable model for front-loading cardiovascular assessment?

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e2-e2

2011

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Orthostatic hypotension can be investigated in conscious dogs as part of standard telemetry studies

Journal of pharmacological and toxicological methods, 2010-09, Vol.62 (2), p.e6-e6

2010

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Echocardiography: A sensitive, clinically translatable biomarker for cardiac contractility

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e29-e29

2011

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The L-type calcium channel: A comparison of automated electrophysiological and ligand-binding data, and prediction of in vivo effects

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e5-e6

2011

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Correlation between ejection fraction and dP/dt+ in conscious telemetered dogs dosed with atenolol

Journal of pharmacological and toxicological methods, 2009-09, Vol.60 (2), p.224-225

2009

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Effects of monocarboxylate transporter 1 (MCT1) inhibition on cardiac function under ischaemic conditions: A comparison between rat and guinea-pig Langendorff hearts

Toxicology letters, 2014-09, Vol.229, p.S238-S238

2014

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Anticoagulant activity and pharmacokinetic properties of a sub-cutaneously administered mixed micellar formulation of argatroban in experimental animals

Thrombosis and haemostasis, 2000-08, Vol.84 (2), p.278-285

2000

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The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds

Functional assessments in repeat-dose toxicity studies: the art of the possible

Cardiac imaging approaches to evaluate drug-induced myocardial dysfunction

Value of non‐clinical cardiac repolarization assays in supporting the discovery and development of safer medicines

Investigation of orthostatic response during telemetry studies: Example with verapamil

Incidence of cardiac contractility issues in safety pharmacology studies: Is the core battery sufficient?

Increased lymphoid tissue apoptosis in baboons with bacteremic shock

Activity in Group-Housed Home Cages of Mice as a Novel Preclinical Biomarker in Oncology Studies

Delayed neutralization of interferon-γ prevents lethality in primate Gram-negative bacteremic shock

Serotonin receptor blockade improves distal perfusion after lower limb ischemia in the fatty Zucker rat

Serotonin aggravates exercise-induced cardiac ischemia in the dog: effect of serotonin receptor antagonists

Assessment of left ventricular dP/dtmax in telemetry studies: Essential or excessive?

Value of non-clinical cardiac repolarization assays in supporting the discovery and development of safer medicines : QT Safety

A comprehensive assessment of cardiovascular risk in telemetered cynomolgus monkeys

Heart rate dependent potentiation of QRS prolongations can be detected in standard dog telemetry studies

Simultaneous assessment of blood pressure and respiratory function in dogs: Validation of a non-invasive telemetry method

Improving methods for ECG recording in dog toxicology studies: Suggestions based on the review of 100 preclinical projects

Cardiac contractility strategy: A case study using early preclinical models

The anaesthetised guinea-pig: A suitable model for front-loading cardiovascular assessment?

Orthostatic hypotension can be investigated in conscious dogs as part of standard telemetry studies

Echocardiography: A sensitive, clinically translatable biomarker for cardiac contractility

The L-type calcium channel: A comparison of automated electrophysiological and ligand-binding data, and prediction of in vivo effects

Correlation between ejection fraction and dP/dt+ in conscious telemetered dogs dosed with atenolol

Effects of monocarboxylate transporter 1 (MCT1) inhibition on cardiac function under ischaemic conditions: A comparison between rat and guinea-pig Langendorff hearts

Anticoagulant activity and pharmacokinetic properties of a sub-cutaneously administered mixed micellar formulation of argatroban in experimental animals

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