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Anticancer Study of a Novel Pan-HDAC Inhibitor MPT0G236 in Colorectal Cancer Cells

International journal of molecular sciences, 2023-08, Vol.24 (16), p.12588

2023

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The HDAC/HSP90 Inhibitor G570 Attenuated Blue Light-Induced Cell Migration in RPE Cells and Neovascularization in Mice through Decreased VEGF Production

Molecules (Basel, Switzerland), 2021-07, Vol.26 (14), p.4359

2021

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5‑Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer’s Disease Phenotypes

Journal of medicinal chemistry, 2018-08, Vol.61 (16), p.7087-7102

2018

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HDAC inhibitor protects chronic cerebral hypoperfusion and oxygen‐glucose deprivation injuries via H3K14 and H4K5 acetylation‐mediated BDNF expression

Journal of cellular and molecular medicine, 2020-06, Vol.24 (12), p.6966-6977

2020

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The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo

Journal of hematology and oncology, 2015-07, Vol.8 (1), p.82, Article 82

2015

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Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo

European journal of medicinal chemistry, 2020-03, Vol.190, p.112086-112086, Article 112086

2020

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3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

European journal of medicinal chemistry, 2017-01, Vol.125, p.1268-1278

2017

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Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status

Clinical epigenetics, 2019-05, Vol.11 (1), p.85-85, Article 85

2019

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Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms

Journal of enzyme inhibition and medicinal chemistry, 2021-01, Vol.36 (1), p.74-84

2021

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1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma

European journal of medicinal chemistry, 2017-11, Vol.140, p.84-91

2017

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Anticancer activity of MPT0E028, a novel potent histone deacetylase inhibitor, in human colorectal cancer HCT116 cells in vitro and in vivo

PloS one, 2012-08, Vol.7 (8), p.e43645-e43645

2012

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Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors

European journal of medicinal chemistry, 2020-06, Vol.196, p.112291, Article 112291

2020

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(N‑Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.905-917

2018

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CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition

European journal of medicinal chemistry, 2021-04, Vol.215, p.113169, Article 113169

2021

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6-Regioisomeric 5,8-quinolinediones as potent CDC25 inhibitors against colorectal cancers

European journal of medicinal chemistry, 2023-10, Vol.258, p.115505-115505, Article 115505

2023

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Rationally designed donepezil-based hydroxamates modulate Sig-1R and HDAC isoforms to exert anti-glioblastoma effects

European journal of medicinal chemistry, 2023-02, Vol.248, p.115054-115054, Article 115054

2023

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1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors

Chembiochem : a European journal of chemical biology, 2013-07, Vol.14 (10), p.1248-1254

2013

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First-in-Class Dual EZH2-HSP90 Inhibitor Eliciting Striking Antiglioblastoma Activity In Vitro and In Vivo

Journal of medicinal chemistry, 2024-02, Vol.67 (4), p.2963-2985

2024

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Dual inhibition of CYP17A1 and HDAC6 by abiraterone-installed hydroxamic acid overcomes temozolomide resistance in glioblastoma through inducing DNA damage and oxidative stress

Cancer letters, 2024-04, Vol.586, p.216666-216666, Article 216666

2024

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Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma

European journal of medicinal chemistry, 2023-08, Vol.256, p.115459-115459, Article 115459

2023

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1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

European journal of medicinal chemistry, 2019-01, Vol.162, p.612-630

2019

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1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

European journal of medicinal chemistry, 2018-04, Vol.150, p.667-677

2018

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Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma

European journal of medicinal chemistry, 2021-05, Vol.217, p.113338-113338, Article 113338

2021

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Ring-opening of five-membered heterocycles conjugated 4-isopropylresorcinol scaffold-based benzamides as HSP90 inhibitors suppressing tumor growth in vitro and in vivo

European journal of medicinal chemistry, 2021-07, Vol.219, p.113428-113428, Article 113428

2021

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Design, synthesis, and evaluation of N-phenyl-4-(2-phenylsulfonamido)-benzamides as microtubule-targeting agents in drug-resistant cancer cells, displaying HDAC inhibitory response

European journal of medicinal chemistry, 2020-04, Vol.192, p.112158-112158, Article 112158

2020

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Anticancer Study of a Novel Pan-HDAC Inhibitor MPT0G236 in Colorectal Cancer Cells

The HDAC/HSP90 Inhibitor G570 Attenuated Blue Light-Induced Cell Migration in RPE Cells and Neovascularization in Mice through Decreased VEGF Production

5‑Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer’s Disease Phenotypes

HDAC inhibitor protects chronic cerebral hypoperfusion and oxygen‐glucose deprivation injuries via H3K14 and H4K5 acetylation‐mediated BDNF expression

The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo

Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status

Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms

1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma

Anticancer activity of MPT0E028, a novel potent histone deacetylase inhibitor, in human colorectal cancer HCT116 cells in vitro and in vivo

Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors

(N‑Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition

6-Regioisomeric 5,8-quinolinediones as potent CDC25 inhibitors against colorectal cancers

Rationally designed donepezil-based hydroxamates modulate Sig-1R and HDAC isoforms to exert anti-glioblastoma effects

1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors

First-in-Class Dual EZH2-HSP90 Inhibitor Eliciting Striking Antiglioblastoma Activity In Vitro and In Vivo

Dual inhibition of CYP17A1 and HDAC6 by abiraterone-installed hydroxamic acid overcomes temozolomide resistance in glioblastoma through inducing DNA damage and oxidative stress

Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma

Ring-opening of five-membered heterocycles conjugated 4-isopropylresorcinol scaffold-based benzamides as HSP90 inhibitors suppressing tumor growth in vitro and in vivo

Design, synthesis, and evaluation of N-phenyl-4-(2-phenylsulfonamido)-benzamides as microtubule-targeting agents in drug-resistant cancer cells, displaying HDAC inhibitory response

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