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Phe19 modification of HDM2-p53 PPI inhibitors to alleviate CYP3A4 metabolism/mechanism-based inhibition liability

Bioorganic & medicinal chemistry letters, 2022-04, Vol.61, p.128625-128625, Article 128625

2022

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Diversity & tractability revisited in collaborative small molecule phenotypic screening library design

Bioorganic & medicinal chemistry, 2020-01, Vol.28 (1), p.115192-115192, Article 115192

2020

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Substituted piperidines as HDM2 inhibitors

Bioorganic & medicinal chemistry letters, 2014-02, Vol.24 (4), p.1026-1030

2014

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Structure–activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53–hDM2 inhibitors

Bioorganic & medicinal chemistry letters, 2016-06, Vol.26 (11), p.2735-2738

2016

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Core modification of substituted piperidines as novel inhibitors of HDM2-p53 protein-protein interaction

Bioorganic & medicinal chemistry letters, 2014-04, Vol.24 (8), p.1983-1986

2014

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Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors

Bioorganic & medicinal chemistry letters, 2009-07, Vol.19 (13), p.3405-3409

2009

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Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors

ACS medicinal chemistry letters, 2016-03, Vol.7 (3), p.324-329

2016

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Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor

ACS medicinal chemistry letters, 2014-05, Vol.5 (5), p.572-575

2014

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Intramolecular Inverse-Electron-Demand Diels−Alder Reactions of Imidazoles with 1,2,4-Triazines: A New Route to 1,2,3,4-Tetrahydro-1,5-naphthyridines and Related Heterocycles

Journal of organic chemistry, 2004-10, Vol.69 (21), p.7171-7182

2004

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Novel Benzimidazole Inhibitors Bind to a Unique Site in the Kinesin Spindle Protein Motor Domain

Biochemistry (Easton), 2010-09, Vol.49 (38), p.8350-8358

2010

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Matcher: An Open-Source Application for Translating Large Structure/Property Data Sets into Insights for Drug Design

Journal of chemical information and modeling, 2023-04, Vol.63 (7), p.1852-1857

2023

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Current and Future Roles of Artificial Intelligence in Medicinal Chemistry Synthesis

Journal of medicinal chemistry, 2020-08, Vol.63 (16), p.8667-8682

2020

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Dienophilicity of Imidazole in Inverse Electron Demand Diels−Alder Reactions. 4. Intermolecular Reactions with 1,2,4-Triazines

Journal of organic chemistry, 2003-05, Vol.68 (11), p.4345-4354

2003

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Strategy for Extending Half-life in Drug Design and Its Significance

ACS medicinal chemistry letters, 2018-06, Vol.9 (6), p.528-533

2018

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Extending 'predict first' to the design-make-test cycle in small-molecule drug discovery

Future medicinal chemistry, 2017-04, Vol.9 (6), p.533-536

2017

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Inverse electron demand Diels -Alder reactions of 1,2,4-triazines with imidazoles and applications in heterocyclic synthesis

Lahue, Brian R

2003

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Chapter 6.2 Six-membered ring systems: Diazines and benzo derivatives

Progress in Heterocyclic Chemistry, 2000, Vol.12, p.263-293

2000

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Chapter 6.2 Six-membered ring systems: Diazines and benzo derivatives

Progress in Heterocyclic Chemistry, 2001, Vol.13, p.261-295

2001

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ChemInform Abstract: Six-Membered Ring Systems: Diazines and Benzo Derivatives

ChemInform, 2001-06, Vol.32 (25), p.no-no

2001

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Six-Membered Ring System: Diazines and Benzo Derivatives

ChemInform, 2003-02, Vol.34 (5), p.no-no

2003

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Dienophilicity of Imidazole in Inverse Electron Demand Diels-Alder Reactions. Part 4. Intermolecular Reactions with 1,2,4-Triazines

ChemInform, 2003-09, Vol.34 (38), p.no-no

2003

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Intramolecular Inverse-Electron-Demand Diels-Alder Reactions of Imidazoles with 1,2,4-Triazines: A New Route to 1,2,3,4-Tetrahydro-1,5-naphthyridines and Related Heterocycles

ChemInform, 2005-02, Vol.36 (7), p.no-no

2005

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Oxidative Processing of Latent Fas in the Endoplasmic Reticulum Controls the Strength of Apoptosis

Molecular and Cellular Biology, 2012-09, Vol.32 (17), p.3464-3478

2012

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Short‐term impacts of cover crops in maritime potato (Solanum tuberosum) systems

Agrosystems, geosciences & environment, 2022, Vol.5 (2), p.n/a

2022

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Abstract GS112: An Epigenome-wide Association Study Paired With Cell-type-specific Data Identifies Key Regulators Of Heart Failure

Circulation research, 2022-08, Vol.131 (Suppl_1)

2022

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Phe19 modification of HDM2-p53 PPI inhibitors to alleviate CYP3A4 metabolism/mechanism-based inhibition liability

Diversity & tractability revisited in collaborative small molecule phenotypic screening library design

Substituted piperidines as HDM2 inhibitors

Structure–activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53–hDM2 inhibitors

Core modification of substituted piperidines as novel inhibitors of HDM2-p53 protein-protein interaction

Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors

Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors

Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor

Intramolecular Inverse-Electron-Demand Diels−Alder Reactions of Imidazoles with 1,2,4-Triazines: A New Route to 1,2,3,4-Tetrahydro-1,5-naphthyridines and Related Heterocycles

Novel Benzimidazole Inhibitors Bind to a Unique Site in the Kinesin Spindle Protein Motor Domain

Matcher: An Open-Source Application for Translating Large Structure/Property Data Sets into Insights for Drug Design

Current and Future Roles of Artificial Intelligence in Medicinal Chemistry Synthesis

Dienophilicity of Imidazole in Inverse Electron Demand Diels−Alder Reactions. 4. Intermolecular Reactions with 1,2,4-Triazines

Strategy for Extending Half-life in Drug Design and Its Significance

Extending 'predict first' to the design-make-test cycle in small-molecule drug discovery

Inverse electron demand Diels -Alder reactions of 1,2,4-triazines with imidazoles and applications in heterocyclic synthesis

Chapter 6.2 Six-membered ring systems: Diazines and benzo derivatives

Chapter 6.2 Six-membered ring systems: Diazines and benzo derivatives

ChemInform Abstract: Six-Membered Ring Systems: Diazines and Benzo Derivatives

Six-Membered Ring System: Diazines and Benzo Derivatives

Dienophilicity of Imidazole in Inverse Electron Demand Diels-Alder Reactions. Part 4. Intermolecular Reactions with 1,2,4-Triazines

Intramolecular Inverse-Electron-Demand Diels-Alder Reactions of Imidazoles with 1,2,4-Triazines: A New Route to 1,2,3,4-Tetrahydro-1,5-naphthyridines and Related Heterocycles

Oxidative Processing of Latent Fas in the Endoplasmic Reticulum Controls the Strength of Apoptosis

Short‐term impacts of cover crops in maritime potato (Solanum tuberosum) systems

Abstract GS112: An Epigenome-wide Association Study Paired With Cell-type-specific Data Identifies Key Regulators Of Heart Failure

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