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Resolving the Reversed Rate Effect of Calcium Channel Blockers on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and the Impact on In Vitro Cardiac Safety Evaluation

Toxicological sciences, 2019-02, Vol.167 (2), p.573-580

2019

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Multi-parametric assessment of cardiomyocyte excitation-contraction coupling using impedance and field potential recording: A tool for cardiac safety assessment

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.201-216

2016

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The hERG channel and risk of drug-acquired cardiac arrhythmia: an overview

Current topics in medicinal chemistry, 2008-09, Vol.8 (13), p.1102-1112

2008

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Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating delayed rectifier potassium current

The Journal of pharmacology and experimental therapeutics, 2006-06, Vol.317 (3), p.1054-1063

2006

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FRESH™ 3D bioprinted cardiac tissue, a bioengineered platform for in vitro pharmacology

APL bioengineering, 2023-12, Vol.7 (4), p.046113-046113

2023

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Human-induced pluripotent stem cell-derived cardiomyocytes have limited IKs for repolarization reserve as revealed by specific KCNQ1/KCNE1 blocker

JRSM cardiovascular disease, 2019-01, Vol.8, p.2048004019854919-2048004019854919

2019

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Recommendations for safety pharmacology evaluations of oligonucleotide-based therapeutics

Nucleic acid therapeutics, 2014-08, Vol.24 (4), p.291-301

2014

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Nonclinical Safety Assessment of the Histone Deacetylase Inhibitor Vorinostat

International journal of toxicology, 2010-01, Vol.29 (1), p.3-19

2010

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Sensitivity, specificity and limitation of in vitro hippocampal slice and neuron-based assays for assessment of drug-induced seizure liability

Toxicology and applied pharmacology, 2021-11, Vol.430, p.115725, Article 115725

2021

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Structure-Activity Relationship and Voltage Dependence for the Drug–Drug Interaction between Amiodarone Analogs and MNI-1 at the L-type Cav Channel

The Journal of pharmacology and experimental therapeutics, 2024-05, Vol.389 (2), p.229-242

2024

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Preclinical pharmacology and pharmacokinetics of CERC‐301, a GluN2B‐selective N‐methyl‐D‐aspartate receptor antagonist

Pharmacology research & perspectives, 2015-12, Vol.3 (6), p.e00198-n/a

2015

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HiPSC-CMs from different sex and ethnic origin donors exhibit qualitatively different responses to several classes of pharmacological challenges

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106598-106598, Article 106598

2019

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Comparative study for the IMI2-NeuroDeRisk project on microelectrode arrays to derisk drug-induced seizure liability

Journal of pharmacological and toxicological methods, 2023-09, Vol.123, p.107297-107297, Article 107297

2023

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Response of human induced pluripotent stem cell-derived cardiomyocytes to several pharmacological agents when intrinsic syncytial pacing is overcome by acute external stimulation

Journal of pharmacological and toxicological methods, 2018-05, Vol.91, p.18-26

2018

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Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Cav channels

Cell, 2022-12, Vol.185 (25), p.4801-4810.e13

2022

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Abstract P2031: Evaluation Of Adenosine Monophosphate-activated Protein Kinase Activator MK-8722 In Human Induced Pluripotent Stem Cell Derived Cardiomyocyte Monolayer And Microtissue (Biowire II) Models

Circulation research, 2022-08, Vol.131 (Suppl_1)

2022

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Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat

The Journal of pharmacology and experimental therapeutics, 2023-07, Vol.386 (1), p.26-34

2023

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Resolving the reversed rate effect of calcium channel blockers on human induced pluripotent stem cell-derived cardiomyocytes and the impact on in vitro cardiac safety evaluation

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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The state of the art in secondary pharmacology and its impact on the safety of new medicines

Nature reviews. Drug discovery, 2024-07, Vol.23 (7), p.525-545

2024

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Author Correction: The state of the art in secondary pharmacology and its impact on the safety of new medicines

Nature reviews. Drug discovery, 2024-07, Vol.23 (7), p.563-563

2024

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Use of FDSS/μCell imaging platform for preclinical cardiac electrophysiology safety screening of compounds in human induced pluripotent stem cell-derived cardiomyocytes

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.217-222

2016

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Assessing Drug-Induced Long QT and Proarrhythmic Risk Using Human Stem-Cell-Derived Cardiomyocytes in a Ca2+ Imaging Assay: Evaluation of 28 CiPA Compounds at Three Test Sites

Toxicological sciences, 2019-08, Vol.170 (2), p.345-356

2019

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Interaction between amiodarone and hepatitis-C virus nucleotide inhibitors in human induced pluripotent stem cell-derived cardiomyocytes and HEK-293 Cav{sub 1.2} over-expressing cells

Toxicology and applied pharmacology, 2016-10, Vol.308

Lagrutta, Armando

2016

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Interaction between amiodarone and hepatitis-C virus nucleotide inhibitors in human induced pluripotent stem cell-derived cardiomyocytes and HEK-293 Cav1.2 over-expressing cells

Toxicology and applied pharmacology, 2016-10, Vol.308, p.66-76

2016

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Resolving the Reversed Rate Effect of Calcium Channel Blockers on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and the Impact on In Vitro Cardiac Safety Evaluation

Multi-parametric assessment of cardiomyocyte excitation-contraction coupling using impedance and field potential recording: A tool for cardiac safety assessment

The hERG channel and risk of drug-acquired cardiac arrhythmia: an overview

Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating delayed rectifier potassium current

FRESH™ 3D bioprinted cardiac tissue, a bioengineered platform for in vitro pharmacology

Human-induced pluripotent stem cell-derived cardiomyocytes have limited IKs for repolarization reserve as revealed by specific KCNQ1/KCNE1 blocker

Recommendations for safety pharmacology evaluations of oligonucleotide-based therapeutics

Nonclinical Safety Assessment of the Histone Deacetylase Inhibitor Vorinostat

Sensitivity, specificity and limitation of in vitro hippocampal slice and neuron-based assays for assessment of drug-induced seizure liability

Structure-Activity Relationship and Voltage Dependence for the Drug–Drug Interaction between Amiodarone Analogs and MNI-1 at the L-type Cav Channel

Preclinical pharmacology and pharmacokinetics of CERC‐301, a GluN2B‐selective N‐methyl‐D‐aspartate receptor antagonist

HiPSC-CMs from different sex and ethnic origin donors exhibit qualitatively different responses to several classes of pharmacological challenges

Comparative study for the IMI2-NeuroDeRisk project on microelectrode arrays to derisk drug-induced seizure liability

Response of human induced pluripotent stem cell-derived cardiomyocytes to several pharmacological agents when intrinsic syncytial pacing is overcome by acute external stimulation

Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Cav channels

Abstract P2031: Evaluation Of Adenosine Monophosphate-activated Protein Kinase Activator MK-8722 In Human Induced Pluripotent Stem Cell Derived Cardiomyocyte Monolayer And Microtissue (Biowire II) Models

Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat

Resolving the reversed rate effect of calcium channel blockers on human induced pluripotent stem cell-derived cardiomyocytes and the impact on in vitro cardiac safety evaluation

Time for a Fully Integrated Nonclinical–Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective

The state of the art in secondary pharmacology and its impact on the safety of new medicines

Author Correction: The state of the art in secondary pharmacology and its impact on the safety of new medicines

Use of FDSS/μCell imaging platform for preclinical cardiac electrophysiology safety screening of compounds in human induced pluripotent stem cell-derived cardiomyocytes

Assessing Drug-Induced Long QT and Proarrhythmic Risk Using Human Stem-Cell-Derived Cardiomyocytes in a Ca2+ Imaging Assay: Evaluation of 28 CiPA Compounds at Three Test Sites

Interaction between amiodarone and hepatitis-C virus nucleotide inhibitors in human induced pluripotent stem cell-derived cardiomyocytes and HEK-293 Cav{sub 1.2} over-expressing cells

Interaction between amiodarone and hepatitis-C virus nucleotide inhibitors in human induced pluripotent stem cell-derived cardiomyocytes and HEK-293 Cav1.2 over-expressing cells

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