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effects of a soluble activin type IIB receptor on obesity and insulin sensitivity

International Journal of Obesity, 2009-11, Vol.33 (11), p.1265-1273

2009

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P1410: RKER‐050, A NOVEL INHIBITOR OF TGF‐Β SUPERFAMILY SIGNALING, INDUCED PLATELET PRODUCTION IN HEALTHY MOUSE MEGAKARYOCYTES

HemaSphere, 2022-06, Vol.6 (Suppl), p.1294-1295

2022

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P1567: ALK2 INHIBITION LOWERED HEPCIDIN AND LIBERATED SPLEEN IRON FOR ERYTHROPOIESIS IN ANEMIA OF INFLAMMATION

HemaSphere, 2022-06, Vol.6 (Suppl), p.1448-1449

2022

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Cloned mice have an obese phenotype not transmitted to their offspring

Nature medicine, 2002-03, Vol.8 (3), p.262-267

2002

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P776: A PHASE 2, OPEN‐LABEL, ASCENDING DOSE STUDY OF KER‐050 FOR THE TREATMENT OF ANEMIA IN PATIENTS WITH VERY LOW, LOW, OR INTERMEDIATE RISK MYELODYSPLASTIC SYNDROMES

HemaSphere, 2022-06, Vol.6, p.671-672

2022

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Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

Cell, 2014-06, Vol.157 (6), p.1279-1291

2014

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P34 RKER-065, a novel ActRII ligand trap, counteracted the negative impact of glucocorticoid treatment on bone and muscle

Neuromuscular disorders : NMD, 2023-10, Vol.33, p.S105-S105

2023

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A Novel Selective Melanocortin-4 Receptor Agonist Reduces Food Intake in Rats and Mice without Producing Aversive Consequences

The Journal of neuroscience, 2000-05, Vol.20 (9), p.3442-3448

2000

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RKER-012, a novel modified ActRIIB ligand trap, attenuated right ventricular cardiomyopathy in a preclinical model of pulmonary arterial hypertension

European heart journal, 2024-10, Vol.45 (Supplement_1)

2024

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P64 An activin type II receptor ligand trap prevented loss of cortical bone strength and cancellous bone mass in a mouse model of severe disuse osteopenia

Neuromuscular disorders : NMD, 2023-10, Vol.33, p.S74-S75

2023

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P33 RKER-065 ameliorated muscle and bone loss in a progressive murine model of Duchenne muscular dystrophy

Neuromuscular disorders : NMD, 2023-10, Vol.33, p.S105-S105

2023

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P.191 RKER-065, a novel muscle and bone anabolic, increased muscle, grip strength and trabecular bone in a mouse model of Duchenne muscular dystrophy

Neuromuscular disorders : NMD, 2022-10, Vol.32, p.S125

2022

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P.127KER-050, a novel muscle anabolic, functions as a ligand trap that binds myo-catabolic TGFβ ligands and has reduced binding affinity for BMP9, a critical vascular remodeling ligand

Neuromuscular disorders : NMD, 2019-10, Vol.29, p.S85-S85

2019

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G.P.3.12 Treatment with a soluble activin receptor type llB attenuates glucocorticoid-induced muscle loss

Neuromuscular disorders : NMD, 2007, Vol.17 (9), p.785-785

2007

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G.P.3.11 Novel myostatin inhibitors increase muscle mass in wild-type and mdx mice

Neuromuscular disorders : NMD, 2007, Vol.17 (9), p.785-785

2007

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Differential Muscle Hypertrophy Is Associated with Satellite Cell Numbers and Akt Pathway Activation Following Activin Type IIB Receptor Inhibition in Mtm1 p.R69C Mice

The American journal of pathology, 2014-06, Vol.184 (6), p.1831-1842

2014

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Inhibition of Activin Receptor Type IIB Increases Strength and Lifespan in Myotubularin-Deficient Mice

The American journal of pathology, 2011-02, Vol.178 (2), p.784-793

2011

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Mice lacking ghrelin receptors resist the development of diet-induced obesity

The Journal of clinical investigation, 2005-12, Vol.115 (12), p.3564-3572

2005

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Combining non-isotopic localization of NPY mRNA with immunocytochemistry

Methods in molecular biology (Clifton, N.J.), 2000, Vol.153, p.199

2000

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The Role of Central Glucagon-Like Peptide-1 in Mediating the Effects of Visceral Illness: Differential Effects in Rats and Mice

Endocrinology (Philadelphia), 2005-01, Vol.146 (1), p.458-462

2005

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Effect of a soluble activin receptor type IIB on androgen-deprivation-induced effects on body composition

Journal of clinical oncology, 2009-05, Vol.27 (15_suppl), p.5133-5133

2009

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M.P.1.03 Preliminary results from single subcutaneous administration of ACE-031, a form of the soluble activin type IIB receptor, in healthy postmenopausal volunteers

Neuromuscular disorders : NMD, 2009-09, Vol.19 (8), p.546-547

2009

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Serotonergic pathways converge upon central melanocortin systems to regulate energy balance

Peptides (New York, N.Y. : 1980), 2005-10, Vol.26 (10), p.1728-1732

2005

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Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle

The Journal of pharmacology and experimental therapeutics, 2019-03, Vol.368 (3), p.435-445

2019

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Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition

PloS one, 2010-09, Vol.5 (9), p.e12707-e12707

2010

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effects of a soluble activin type IIB receptor on obesity and insulin sensitivity

P1410: RKER‐050, A NOVEL INHIBITOR OF TGF‐Β SUPERFAMILY SIGNALING, INDUCED PLATELET PRODUCTION IN HEALTHY MOUSE MEGAKARYOCYTES

P1567: ALK2 INHIBITION LOWERED HEPCIDIN AND LIBERATED SPLEEN IRON FOR ERYTHROPOIESIS IN ANEMIA OF INFLAMMATION

Cloned mice have an obese phenotype not transmitted to their offspring

P776: A PHASE 2, OPEN‐LABEL, ASCENDING DOSE STUDY OF KER‐050 FOR THE TREATMENT OF ANEMIA IN PATIENTS WITH VERY LOW, LOW, OR INTERMEDIATE RISK MYELODYSPLASTIC SYNDROMES

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

P34 RKER-065, a novel ActRII ligand trap, counteracted the negative impact of glucocorticoid treatment on bone and muscle

A Novel Selective Melanocortin-4 Receptor Agonist Reduces Food Intake in Rats and Mice without Producing Aversive Consequences

RKER-012, a novel modified ActRIIB ligand trap, attenuated right ventricular cardiomyopathy in a preclinical model of pulmonary arterial hypertension

P64 An activin type II receptor ligand trap prevented loss of cortical bone strength and cancellous bone mass in a mouse model of severe disuse osteopenia

P33 RKER-065 ameliorated muscle and bone loss in a progressive murine model of Duchenne muscular dystrophy

P.191 RKER-065, a novel muscle and bone anabolic, increased muscle, grip strength and trabecular bone in a mouse model of Duchenne muscular dystrophy

P.127KER-050, a novel muscle anabolic, functions as a ligand trap that binds myo-catabolic TGFβ ligands and has reduced binding affinity for BMP9, a critical vascular remodeling ligand

G.P.3.12 Treatment with a soluble activin receptor type llB attenuates glucocorticoid-induced muscle loss

G.P.3.11 Novel myostatin inhibitors increase muscle mass in wild-type and mdx mice

Differential Muscle Hypertrophy Is Associated with Satellite Cell Numbers and Akt Pathway Activation Following Activin Type IIB Receptor Inhibition in Mtm1 p.R69C Mice

Inhibition of Activin Receptor Type IIB Increases Strength and Lifespan in Myotubularin-Deficient Mice

Mice lacking ghrelin receptors resist the development of diet-induced obesity

Combining non-isotopic localization of NPY mRNA with immunocytochemistry

The Role of Central Glucagon-Like Peptide-1 in Mediating the Effects of Visceral Illness: Differential Effects in Rats and Mice

Effect of a soluble activin receptor type IIB on androgen-deprivation-induced effects on body composition

M.P.1.03 Preliminary results from single subcutaneous administration of ACE-031, a form of the soluble activin type IIB receptor, in healthy postmenopausal volunteers

Serotonergic pathways converge upon central melanocortin systems to regulate energy balance

Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle

Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition

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