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New 4-Point Pharmacophore Method for Molecular Similarity and Diversity Applications: Overview of the Method and Applications, Including a Novel Approach to the Design of Combinatorial Libraries Containing Privileged Substructures

Journal of medicinal chemistry, 1999-08, Vol.42 (17), p.3251-3264

1999

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Tafamidis for transthyretin familial amyloid polyneuropathy: a randomized, controlled trial

Neurology, 2012-08, Vol.79 (8), p.785-792

2012

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The Discovery of Tadalafil: A Novel and Highly Selective PDE5 Inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1‘,2‘:1,6]pyrido[3,4-b]indole-1,4-dione Analogues

Journal of medicinal chemistry, 2003-10, Vol.46 (21), p.4533-4542

2003

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The Discovery of Tadalafil: A Novel and Highly Selective PDE5 Inhibitor. 1: 5,6,11,11a-Tetrahydro-1H-imidazo[1‘,5‘:1,6]pyrido[3,4-b]indole-1,3(2H)-dione Analogues

Journal of medicinal chemistry, 2003-10, Vol.46 (21), p.4525-4532

2003

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Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy

Journal of neurology, 2013-11, Vol.260 (11), p.2802-2814

2013

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RPR's approach to high-speed parallel synthesis for lead generation

Drug Discovery Today, 1998-11, Vol.3 (11), p.511-515

Labaudiniere, Richard F.

1998

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Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis

Neurology and Therapy, 2016-06, Vol.5 (1), p.1-25

2016

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Novel safety-catch linker and its application with a Ugi/De-BOC/Cyclization (UDC) strategy to access carboxylic acids, 1,4-benzodiazepines, diketopiperazines, ketopiperazines and dihydroquinoxalinones

Tetrahedron letters, 1998-10, Vol.39 (40), p.7227-7230

1998

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Synthesis of vinyl selenides or sulfides and ketene selenoacetals or thioacetals by nickel(II) vinylation of sodium benzeneselenolate or benzenethiolate

Journal of organic chemistry, 1986-03, Vol.51 (6), p.875-878

1986

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Improved Procedure for the Solution Phase Preparation of 1,4-Benzodiazepine-2,5-dione Libraries via Armstrong's Convertible Isonitrile and the Ugi Reaction

Journal of organic chemistry, 1998-10, Vol.63 (22), p.8021-8023

1998

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Novel applications of carbon dioxide/MeOH for the synthesis of hydantoins and cyclic ureas via the Ugi reaction

Tetrahedron letters, 2000-03, Vol.41 (12), p.1889-1893

2000

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Novel applications of resin bound α-amino acids for the synthesis of benzodiazepines (via Wang resin) and ketopiperazines (via hydroxymethyl resin)

Tetrahedron letters, 2000-03, Vol.41 (10), p.1509-1514

2000

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Novel applications of convertible isonitriles for the synthesis of mono and bicyclic γ-lactams via a UDC strategy

Tetrahedron letters, 2000-03, Vol.41 (12), p.1883-1887

2000

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Synthesis and Binding Affinities of Novel Spirocyclic Lactam Peptidomimetics of Somatostatin

Chemistry letters, 1998-09, Vol.27 (9), p.943-944

1998

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Parallel Synthesis of Aldehydes and Ketone Facilitated by a New Solid-Phase Weinreb Amide

Journal of organic chemistry, 1999-03, Vol.64 (6), p.1823-1830

1999

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Rhone-Poulenc Rorer's approach to high-speed parallel synthesis for lead generation

Drug discovery today, 1998-11, Vol.3 (11), p.511-515

Labaudiniere, R F

1998

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omega.-[(4-Phenyl-2-quinolyl)oxy]alkanoic acid derivatives: a new family of potent LTB4 antagonists

Journal of medicinal chemistry, 1992-11, Vol.35 (23), p.4306-4314

1992

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omega.-[(4,6-Diphenyl-2-pyridyl)oxy]alkanoic acid derivatives: a new family of potent and orally active LTB4 antagonists

Journal of medicinal chemistry, 1992-11, Vol.35 (23), p.4315-4324

1992

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omega.-[(.omega.-Arylalkyl)thienyl]alkanoic acids: from specific LTA4 hydrolase inhibitors to LTB4 receptor antagonists

Journal of medicinal chemistry, 1992-08, Vol.35 (17), p.3170-3179

1992

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Synthesis of aryl phenyl and heteroaryl phenyl selenides by nickel(II)-catalyzed arylation of sodium benzeneselenolate

Organometallics, 1985-04, Vol.4 (4), p.657-661

1985

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Dual Inhibition of Phosphodiesterase 4 and Matrix Metalloproteinases by an (Arylsulfonyl)hydroxamic Acid Template

Journal of medicinal chemistry, 1999-02, Vol.42 (4), p.541-544

1999

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The Bioactive Conformation of Human Parathyroid Hormone. Structural Evidence for the Extended Helix Postulate

Journal of the American Chemical Society, 2000-04, Vol.122 (13), p.3007-3014

2000

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Synthesis of a regioselectively hexadeuterated linoleic acid

Journal of organic chemistry, 1993-02, Vol.58 (5), p.1280-1283

1993

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Synthesis and diversity analysis of lead discovery piperazine-2-carboxamide libraries

Molecular diversity, 1998-01, Vol.4 (4), p.221-232

1998

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The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I

Bioorganic & medicinal chemistry letters, 1998-07, Vol.8 (14), p.1867-1872

1998

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New 4-Point Pharmacophore Method for Molecular Similarity and Diversity Applications: Overview of the Method and Applications, Including a Novel Approach to the Design of Combinatorial Libraries Containing Privileged Substructures

Tafamidis for transthyretin familial amyloid polyneuropathy: a randomized, controlled trial

The Discovery of Tadalafil: A Novel and Highly Selective PDE5 Inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1‘,2‘:1,6]pyrido[3,4-b]indole-1,4-dione Analogues

The Discovery of Tadalafil: A Novel and Highly Selective PDE5 Inhibitor. 1: 5,6,11,11a-Tetrahydro-1H-imidazo[1‘,5‘:1,6]pyrido[3,4-b]indole-1,3(2H)-dione Analogues

Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy

RPR's approach to high-speed parallel synthesis for lead generation

Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis

Novel safety-catch linker and its application with a Ugi/De-BOC/Cyclization (UDC) strategy to access carboxylic acids, 1,4-benzodiazepines, diketopiperazines, ketopiperazines and dihydroquinoxalinones

Synthesis of vinyl selenides or sulfides and ketene selenoacetals or thioacetals by nickel(II) vinylation of sodium benzeneselenolate or benzenethiolate

Improved Procedure for the Solution Phase Preparation of 1,4-Benzodiazepine-2,5-dione Libraries via Armstrong's Convertible Isonitrile and the Ugi Reaction

Novel applications of carbon dioxide/MeOH for the synthesis of hydantoins and cyclic ureas via the Ugi reaction

Novel applications of resin bound α-amino acids for the synthesis of benzodiazepines (via Wang resin) and ketopiperazines (via hydroxymethyl resin)

Novel applications of convertible isonitriles for the synthesis of mono and bicyclic γ-lactams via a UDC strategy

Synthesis and Binding Affinities of Novel Spirocyclic Lactam Peptidomimetics of Somatostatin

Parallel Synthesis of Aldehydes and Ketone Facilitated by a New Solid-Phase Weinreb Amide

Rhone-Poulenc Rorer's approach to high-speed parallel synthesis for lead generation

omega.-[(4-Phenyl-2-quinolyl)oxy]alkanoic acid derivatives: a new family of potent LTB4 antagonists

omega.-[(4,6-Diphenyl-2-pyridyl)oxy]alkanoic acid derivatives: a new family of potent and orally active LTB4 antagonists

omega.-[(.omega.-Arylalkyl)thienyl]alkanoic acids: from specific LTA4 hydrolase inhibitors to LTB4 receptor antagonists

Synthesis of aryl phenyl and heteroaryl phenyl selenides by nickel(II)-catalyzed arylation of sodium benzeneselenolate

Dual Inhibition of Phosphodiesterase 4 and Matrix Metalloproteinases by an (Arylsulfonyl)hydroxamic Acid Template

The Bioactive Conformation of Human Parathyroid Hormone. Structural Evidence for the Extended Helix Postulate

Synthesis of a regioselectively hexadeuterated linoleic acid

Synthesis and diversity analysis of lead discovery piperazine-2-carboxamide libraries

The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I

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