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RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Nature communications, 2019-01, Vol.10 (1), p.9-15, Article 9

2019

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Paradoxical Augmentation of Experimental Spondyloarthritis by RORC Inhibition in HLA-B27 Transgenic Rats

Frontiers in immunology, 2021-09, Vol.12, p.699987-699987

2021

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Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORγt

European journal of immunology, 2008-05, Vol.38 (5), p.1204-1214

2008

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Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors

The Journal of biological chemistry, 2017-07, Vol.292 (28), p.11618-11630

2017

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Involvement of GATA3 in Protein Kinase C θ‐induced Th2 cytokine expression

European journal of immunology, 2006-12, Vol.36 (12), p.3305-3314

2006

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High-Affinity Interactions of Tumor Necrosis Factor Receptor-Associated Factors (TRAFs) and CD40 Require TRAF Trimerization and CD40 Multimerization

Biochemistry (Easton), 1999-08, Vol.38 (31), p.10168-10177

1999

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Molecular Regulation of the Interaction Between Leukocyte Function-Associated Antigen-1 and Soluble ICAM-1 by Divalent Metal Cations

The Journal of immunology (1950), 1998-07, Vol.161 (2), p.836-842

1998

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Discovery and Characterization of a Substrate Selective p38α Inhibitor

Biochemistry (Easton), 2004-09, Vol.43 (37), p.11658-11671

2004

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Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors

Journal of medicinal chemistry, 2002-12, Vol.45 (25), p.5471-5482

2002

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Catalysis and Function of the p38α·MK2a Signaling Complex

Biochemistry (Easton), 2004-08, Vol.43 (31), p.9950-9960

2004

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The determination and correlation of molecular and cellular equilibrium Kd and kinetic koff values for small molecule allosteric antagonists of LFA-1

Biochemical pharmacology, 2007-06, Vol.74 (1), p.98-106

2007

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Agonist versus antagonist induce distinct thermodynamic modes of co-factor binding to the glucocorticoid receptor

Biophysical chemistry, 2007-07, Vol.128 (2), p.156-164

2007

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Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors

Bioorganic & medicinal chemistry letters, 2007-05, Vol.17 (9), p.2465-2469

2007

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The design of potent hydrazones and disulfides as cathepsin S inhibitors

Bioorganic & medicinal chemistry, 2003-03, Vol.11 (5), p.733-740

2003

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Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors

Journal of medicinal chemistry, 2003-02, Vol.46 (5), p.882-882

2003

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A synthetic peptide containing a predominant protein kinase C site within p47phox inhibits the NADPH oxidase in intact neutrophils

Journal of leukocyte biology, 1996-01, Vol.59 (1), p.116-124

1996

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The determination and correlation of molecular and cellular equilibrium Kd and kinetic k(off) values for small molecule allosteric antagonists of LFA-1

Biochemical pharmacology, 2007-06, Vol.74 (1), p.98-106

2007

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Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t

European journal of immunology, 2008-05, Vol.38 (5), p.1204-1214

2008

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The determination and correlation of molecular and cellular equilibrium K d and kinetic k off values for small molecule allosteric antagonists of LFA-1

Biochemical pharmacology, 2007, Vol.74 (1), p.98-106

2007

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Epstein-Barr virus-induced gene 3 is a negative regulator of IL-17 and protective immunity against Listeria monocytogenes (95.4)

The Journal of immunology (1950), 2007-04, Vol.178 (1_Supplement), p.S177-S177

2007

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Involvement of GATA3 in Protein Kinase C [thgr]-induced Th2 cytokine expression

European Journal of Immunology, 2006-01, Vol.36 (12), p.3305-3314

2006

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Catalysis and function of the p38 alpha.MK2a signaling complex

Biochemistry (Easton), 2004-08, Vol.43 (31), p.9950-9960

2004

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Discovery and characterization of a substrate selective p38alpha inhibitor

Biochemistry (Easton), 2004-09, Vol.43 (37), p.11658-11671

2004

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The Primary Structure of a Human Map Kinase Activated Protein Kinase 2

Biochemical and biophysical research communications, 1994-04, Vol.200 (2), p.1118-1124

1994

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Interaction between the SH2 Domains of ZAP-70 and the Tyrosine-Based Activation Motif 1 Sequence of the ζ Subunit of the T-Cell Receptor

Archives of biochemistry and biophysics, 1997-06, Vol.342 (1), p.117-125

1997

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RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Paradoxical Augmentation of Experimental Spondyloarthritis by RORC Inhibition in HLA-B27 Transgenic Rats

Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORγt

Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors

Involvement of GATA3 in Protein Kinase C θ‐induced Th2 cytokine expression

High-Affinity Interactions of Tumor Necrosis Factor Receptor-Associated Factors (TRAFs) and CD40 Require TRAF Trimerization and CD40 Multimerization

Molecular Regulation of the Interaction Between Leukocyte Function-Associated Antigen-1 and Soluble ICAM-1 by Divalent Metal Cations

Discovery and Characterization of a Substrate Selective p38α Inhibitor

Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors

Catalysis and Function of the p38α·MK2a Signaling Complex

The determination and correlation of molecular and cellular equilibrium Kd and kinetic koff values for small molecule allosteric antagonists of LFA-1

Agonist versus antagonist induce distinct thermodynamic modes of co-factor binding to the glucocorticoid receptor

Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors

The design of potent hydrazones and disulfides as cathepsin S inhibitors

Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors

A synthetic peptide containing a predominant protein kinase C site within p47phox inhibits the NADPH oxidase in intact neutrophils

The determination and correlation of molecular and cellular equilibrium Kd and kinetic k(off) values for small molecule allosteric antagonists of LFA-1

Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t

The determination and correlation of molecular and cellular equilibrium K d and kinetic k off values for small molecule allosteric antagonists of LFA-1

Epstein-Barr virus-induced gene 3 is a negative regulator of IL-17 and protective immunity against Listeria monocytogenes (95.4)

Involvement of GATA3 in Protein Kinase C [thgr]-induced Th2 cytokine expression

Catalysis and function of the p38 alpha.MK2a signaling complex

Discovery and characterization of a substrate selective p38alpha inhibitor

The Primary Structure of a Human Map Kinase Activated Protein Kinase 2

Interaction between the SH2 Domains of ZAP-70 and the Tyrosine-Based Activation Motif 1 Sequence of the ζ Subunit of the T-Cell Receptor

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