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Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines

Bioorganic & medicinal chemistry letters, 2013-09, Vol.23 (17), p.4968-4974

2013

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Combining the FtsZ-Targeting Prodrug TXA709 and the Cephalosporin Cefdinir Confers Synergy and Reduces the Frequency of Resistance in Methicillin-Resistant Staphylococcus aureus

Antimicrobial agents and chemotherapy, 2016-07, Vol.60 (7), p.4290-4296

2016

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Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ

ACS chemical biology, 2017-07, Vol.12 (7), p.1947-1955

2017

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An FtsZ-Targeting Prodrug with Oral Antistaphylococcal Efficacy In Vivo

Antimicrobial Agents and Chemotherapy, 2013-12, Vol.57 (12), p.5860-5869

2013

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Structure-Guided Design of a Fluorescent Probe for the Visualization of FtsZ in Clinically Important Gram-Positive and Gram-Negative Bacterial Pathogens

Scientific reports, 2019-12, Vol.9 (1), p.20092-16, Article 20092

2019

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Pharmacokinetics and in vivo antistaphylococcal efficacy of TXY541, a 1-methylpiperidine-4-carboxamide prodrug of PC190723

Biochemical pharmacology, 2013-12, Vol.86 (12), p.1699-1707

2013

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Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors

ACS chemical biology, 2013-11, Vol.8 (11), p.2501-2508

2013

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A FtsZ Inhibitor That Can Utilize Siderophore-Ferric Iron Uptake Transporter Systems for Activity against Gram-Negative Bacterial Pathogens

Antibiotics (Basel), 2024-02, Vol.13 (3), p.209

2024

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Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives

Bioorganic & medicinal chemistry letters, 2012-11, Vol.22 (22), p.6962-6966

2012

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Bioisosterism: A Rational Approach in Drug Design

Chemical reviews, 1996-12, Vol.96 (8), p.3147-3176

1996

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TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens

Antibiotics (Basel), 2022-05, Vol.11 (5), p.693

2022

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Enterococcal and streptococcal resistance to PC190723 and related compounds: Molecular insights from a FtsZ mutational analysis

Biochimie, 2013-10, Vol.95 (10), p.1880-1887

2013

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Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes

European journal of medicinal chemistry, 2013-02, Vol.60, p.395-409

2013

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Antioxidative Phenolic Compounds from Sage (Salvia officinalis)

Journal of agricultural and food chemistry, 1998-12, Vol.46 (12), p.4869-4873

1998

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Genz-644282, a Novel Non-Camptothecin Topoisomerase I Inhibitor for Cancer Treatment

Clinical cancer research, 2011-05, Vol.17 (9), p.2777-2787

2011

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Macrocyclic biphenyl tetraoxazoles: Synthesis, evaluation as G-quadruplex stabilizers and cytotoxic activity

Bioorganic & medicinal chemistry, 2013-08, Vol.21 (15), p.4511-4520

2013

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Determination of the Predominant Catechins in Acacia catechu by Liquid Chromatography/Electrospray Ionization−Mass Spectrometry

Journal of agricultural and food chemistry, 2006-05, Vol.54 (9), p.3219-3224

2006

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A G-quadruplex Stabilizer Induces M-phase Cell Cycle Arrest

The Journal of biological chemistry, 2009-08, Vol.284 (34), p.22535-22543

2009

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Macrocyclic pyridyl polyoxazoles: structure-activity studies of the aminoalkyl side-chain on G-quadruplex stabilization and cytotoxic activity

Molecules (Basel, Switzerland), 2013-09, Vol.18 (10), p.11938-11963

2013

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Structure-activity relationships of potentiators of the antibiotic activity of clarithromycin against Escherichia coli

European journal of medicinal chemistry, 2019-09, Vol.178, p.30-38

2019

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TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus

Antimicrobial agents and chemotherapy, 2015-08, Vol.59 (8), p.4845-4855

2015

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Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (10), p.3150-3154

2010

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Phenyl Substituted 4‑Hydroxypyridazin-3(2H)‑ones and 5‑Hydroxypyrimidin-4(3H)‑ones: Inhibitors of Influenza A Endonuclease

Journal of medicinal chemistry, 2014-10, Vol.57 (19), p.8086-8098

2014

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Stimulation of Topoisomerase II-Mediated DNA Damage via a Mechanism Involving Protein Thiolation

Biochemistry (Easton), 2001-03, Vol.40 (11), p.3316-3323

2001

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β-Lactam Antibiotics with a High Affinity for PBP2 Act Synergistically with the FtsZ-Targeting Agent TXA707 against Methicillin-Resistant Staphylococcus aureus

Antimicrobial agents and chemotherapy, 2017-09, Vol.61 (9)

2017

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Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines

Combining the FtsZ-Targeting Prodrug TXA709 and the Cephalosporin Cefdinir Confers Synergy and Reduces the Frequency of Resistance in Methicillin-Resistant Staphylococcus aureus

Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ

An FtsZ-Targeting Prodrug with Oral Antistaphylococcal Efficacy In Vivo

Structure-Guided Design of a Fluorescent Probe for the Visualization of FtsZ in Clinically Important Gram-Positive and Gram-Negative Bacterial Pathogens

Pharmacokinetics and in vivo antistaphylococcal efficacy of TXY541, a 1-methylpiperidine-4-carboxamide prodrug of PC190723

Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors

A FtsZ Inhibitor That Can Utilize Siderophore-Ferric Iron Uptake Transporter Systems for Activity against Gram-Negative Bacterial Pathogens

Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives

Bioisosterism: A Rational Approach in Drug Design

TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens

Enterococcal and streptococcal resistance to PC190723 and related compounds: Molecular insights from a FtsZ mutational analysis

Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes

Antioxidative Phenolic Compounds from Sage (Salvia officinalis)

Genz-644282, a Novel Non-Camptothecin Topoisomerase I Inhibitor for Cancer Treatment

Macrocyclic biphenyl tetraoxazoles: Synthesis, evaluation as G-quadruplex stabilizers and cytotoxic activity

Determination of the Predominant Catechins in Acacia catechu by Liquid Chromatography/Electrospray Ionization−Mass Spectrometry

A G-quadruplex Stabilizer Induces M-phase Cell Cycle Arrest

Macrocyclic pyridyl polyoxazoles: structure-activity studies of the aminoalkyl side-chain on G-quadruplex stabilization and cytotoxic activity

Structure-activity relationships of potentiators of the antibiotic activity of clarithromycin against Escherichia coli

TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus

Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity

Phenyl Substituted 4‑Hydroxypyridazin-3(2H)‑ones and 5‑Hydroxypyrimidin-4(3H)‑ones: Inhibitors of Influenza A Endonuclease

Stimulation of Topoisomerase II-Mediated DNA Damage via a Mechanism Involving Protein Thiolation

β-Lactam Antibiotics with a High Affinity for PBP2 Act Synergistically with the FtsZ-Targeting Agent TXA707 against Methicillin-Resistant Staphylococcus aureus

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