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Cannabis sativa terpenes are cannabimimetic and selectively enhance cannabinoid activity

Scientific reports, 2021-04, Vol.11 (1), p.8232-15, Article 8232

2021

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Physiological roles of mammalian transmembrane adenylyl cyclase isoforms

Physiological reviews, 2022-04, Vol.102 (2), p.815-857

2022

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Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype

Frontiers in pharmacology, 2022-09, Vol.13, p.977742

2022

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CCK2 receptors in chronic pain

Neurobiology of pain, 2022-01, Vol.11, p.100092-100092, Article 100092

2022

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Pain-related behavioral and electrophysiological actions of dynorphin A (1-17)

Molecular pain, 2023-01, Vol.19, p.17448069231186592-17448069231186592

2023

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Optimization of a Pyrimidinone Series for Selective Inhibition of Ca2+/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain

Journal of medicinal chemistry, 2022-03, Vol.65 (6), p.4667-4686

2022

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Optimization of a Pyrimidinone Series for Selective Inhibition of Ca 2+ /Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain

Journal of medicinal chemistry, 2022-03, Vol.65 (6), p.4667-4686

2022

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Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism

Biomedicines, 2021-05, Vol.9 (6), p.625

2021

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In Defense of the “Entourage Effect”: Terpenes Found in Cannabis sativa Activate the Cannabinoid Receptor 1 In Vitro

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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In Defense of the “Entourage Effect”: Terpenes Found in Cannabis sativa Activate the Cannabinoid Receptor 1 In Vivo

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Analgesic Potential of Terpenes Derived from Cannabis sativa

Pharmacological reviews, 2021-10, Vol.73 (4), p.98-1297

2021

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Precise Neuronal Mechanisms of Spinal Dynorphin in Chronic Pain

The journal of pain, 2022-05, Vol.23 (5), p.10-10

2022

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Brain Penetrant Humanized scFv Antibody Block of P2 × 4 Receptor for Treatment of Chronic Pain

The journal of pain, 2022-05, Vol.23 (5), p.27-27

2022

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Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention

Cephalalgia, 2017-07, Vol.37 (8), p.780-794

2017

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The endomorphin-1/2 and dynorphin-B peptides display biased agonism at the mu opioid receptor

Pharmacological reports, 2020-04, Vol.72 (2), p.465-471

2020

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Exploring Opioid and Cannabis Pharmacology: Biased Signaling of Endogenous Opioid Peptides and Cannabimimetic Properties of Cannabis Sativa Terpenes

LaVigne, Justin

2020

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Phosphatidylethanolamine‐Binding Protein Promotes Opioid Anti‐Nociception in the Brain and Spinal Cord by Reducing βarrestin2 Recruitment to the Mu Opioid Receptor

The FASEB journal, 2018-04, Vol.32 (S1), p.689.3-689.3

2018

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Phosphatidylethanolamine‐Binding Protein Regulates Mu Opioid Receptor Induced βarrestin2 Recruitment and Downstream Signaling

The FASEB journal, 2015-04, Vol.29 (S1)

2015

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Novel Molecular Strategies and Targets for Opioid Drug Discovery for the Treatment of Chronic Pain

The Yale journal of biology & medicine, 2017-03, Vol.90 (1), p.97-110

2017

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The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence

Pharmacology, biochemistry and behavior, 2015-05, Vol.132, p.49-55

2015

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Structure–Activity Relationships of [des-Arg7]Dynorphin A Analogues at the κ Opioid Receptor

Journal of medicinal chemistry, 2016-11, Vol.59 (22), p.10291-10298

2016

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Identification of novel signaling regulators of the mu opioid receptor (1066.1)

The FASEB journal, 2014-04, Vol.28 (S1), p.n/a

2014

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The development of bifunctional ligands as novel therapeutics for chronic pain (1061.5)

The FASEB journal, 2014-04, Vol.28 (S1), p.n/a

2014

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The mixed-action delta/mu opioid agonst MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence

Pharmacology, biochemistry and behavior, 2015-02, Vol.132, p.49-55

2015

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CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity

Nature genetics, 2018-04, Vol.50 (4), p.603-612

2018

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Cannabis sativa terpenes are cannabimimetic and selectively enhance cannabinoid activity

Physiological roles of mammalian transmembrane adenylyl cyclase isoforms

Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype

CCK2 receptors in chronic pain

Pain-related behavioral and electrophysiological actions of dynorphin A (1-17)

Optimization of a Pyrimidinone Series for Selective Inhibition of Ca2+/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain

Optimization of a Pyrimidinone Series for Selective Inhibition of Ca 2+ /Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain

Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism

In Defense of the “Entourage Effect”: Terpenes Found in Cannabis sativa Activate the Cannabinoid Receptor 1 In Vitro

In Defense of the “Entourage Effect”: Terpenes Found in Cannabis sativa Activate the Cannabinoid Receptor 1 In Vivo

Analgesic Potential of Terpenes Derived from Cannabis sativa

Precise Neuronal Mechanisms of Spinal Dynorphin in Chronic Pain

Brain Penetrant Humanized scFv Antibody Block of P2 × 4 Receptor for Treatment of Chronic Pain

Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention

The endomorphin-1/2 and dynorphin-B peptides display biased agonism at the mu opioid receptor

Exploring Opioid and Cannabis Pharmacology: Biased Signaling of Endogenous Opioid Peptides and Cannabimimetic Properties of Cannabis Sativa Terpenes

Phosphatidylethanolamine‐Binding Protein Promotes Opioid Anti‐Nociception in the Brain and Spinal Cord by Reducing βarrestin2 Recruitment to the Mu Opioid Receptor

Phosphatidylethanolamine‐Binding Protein Regulates Mu Opioid Receptor Induced βarrestin2 Recruitment and Downstream Signaling

Novel Molecular Strategies and Targets for Opioid Drug Discovery for the Treatment of Chronic Pain

The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence

Structure–Activity Relationships of [des-Arg7]Dynorphin A Analogues at the κ Opioid Receptor

Identification of novel signaling regulators of the mu opioid receptor (1066.1)

The development of bifunctional ligands as novel therapeutics for chronic pain (1061.5)

The mixed-action delta/mu opioid agonst MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence

CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity

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