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Evolving Concepts in Uromodulin Biology, Physiology, and Its Role in Disease: a Tale of Two Forms

Hypertension (Dallas, Tex. 1979), 2022-11, Vol.79 (11), p.2409-2418

2022

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A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease

Nature communications, 2023-07, Vol.14 (1), p.4140-17, Article 4140

2023

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The kidney protects against sepsis by producing systemic uromodulin

American journal of physiology. Renal physiology, 2022-08, Vol.323 (2), p.F212-F226

2022

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Characterization of Plasmodium Atg3-Atg8 Interaction Inhibitors Identifies Novel Alternative Mechanisms of Action in Toxoplasma gondii

Antimicrobial agents and chemotherapy, 2018-02, Vol.62 (2)

2018

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Autosomal dominant tubulointerstitial kidney disease: a new tool to guide genetic testing

Kidney international, 2020-09, Vol.98 (3), p.549-552

2020

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Systemic Effects of Tamm-Horsfall Protein in Kidney Disease

Seminars in nephrology, 2022-05, Vol.42 (3), p.151277-151277, Article 151277

2022

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The kidney releases a nonpolymerizing form of uromodulin in the urine and circulation that retains the external hydrophobic patch domain

American journal of physiology. Renal physiology, 2022-04, Vol.322 (4), p.F403-F418

2022

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Water Loading and Uromodulin Secretion in Healthy Individuals and Idiopathic Calcium Stone Formers

Clinical journal of the American Society of Nephrology, 2023-08, Vol.18 (8), p.1059-1067

2023

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Healthy Women Have Higher Systemic Uromodulin Levels: Identification of Uromodulin as an Estrogen Responsive Gene

Kidney360, 2023-09, Vol.4 (9), p.e1302-e1307

2023

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Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes

Transplantation, 2021-04, Vol.105 (4), p.876-885

2021

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A novel dense granule protein, GRA41, regulates timing of egress and calcium sensitivity in Toxoplasma gondii

Cellular microbiology, 2017-09, Vol.19 (9), p.e12749-n/a

2017

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Inhibition of Apurinic/Apyrimidinic Endonuclease I’s Redox Activity Revisited

Biochemistry (Easton), 2013-04, Vol.52 (17), p.2955-2966

2013

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Healthy Women Have Higher Systemic Uromodulin Levels: Identification of Uromodulin as an Estrogen Responsive Gene: FR-PO841

Journal of the American Society of Nephrology, 2023-11, Vol.34 (11S), p.638-638

2023

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Myeloid Cell Deletion of the Cationic Channel TRPM2, a Target of Uromodulin Inhibition, Is Protective in Murine Sepsis: SA-PO183

Journal of the American Society of Nephrology, 2023-11, Vol.34 (11S), p.773-773

2023

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Uromodulin Deficiency Shapes AKI Severity by Enhanced Oxidative Injury and Stress Response in Proximal Tubules With Early Activation of the Inflammasome: FR-PO150

Journal of the American Society of Nephrology, 2022-11, Vol.33 (11S), p.366-366

2022

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The Kidney Produces a Non-Polymerizing Form of Uromodulin That Associates with Reduced Risk of AKI: PO0419

Journal of the American Society of Nephrology, 2021-10, Vol.32 (10S), p.172-173

2021

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Alternative Splicing Generates an Intracellular Uromodulin Isoform that Mediates Mitochondrial Function and Is Up-Regulated in AKI: FR-PO184

Journal of the American Society of Nephrology, 2023-11, Vol.34 (11S), p.455-455

2023

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Transcriptomic Profiling of Thick Ascending Limb Cells In Vivo Reveals the Complex Network of Genes Regulated by Uromodulin: PO0629

Journal of the American Society of Nephrology, 2020-10, Vol.31 (10S), p.240-240

2020

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Variability in Uromodulin Production and Its Response to Water Loading in Healthy Subjects and Patients With Stone Disease: SA-PO170

Journal of the American Society of Nephrology, 2022-11, Vol.33 (11S), p.649-649

2022

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Detection of Myeloid Cell Pleiotropy In Situ and the Unique Niches of Immune Cells in Ischemic Kidney Injury Using CODEX Imaging: FR-PO149

Journal of the American Society of Nephrology, 2022-11, Vol.33 (11S), p.366-366

2022

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Uromodulin and Injury Severity Alter Neutrophil Diversity and Signaling in AKI: FR-PO154

Journal of the American Society of Nephrology, 2022-11, Vol.33 (11S), p.367-367

2022

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A Spatially Anchored Transcriptomic Atlas of the Human Kidney Papilla Identifies Significant Immune Injury and Matrix Remodeling in Stone Disease Patients: FR-OR09

Journal of the American Society of Nephrology, 2022-11, Vol.33 (11S), p.20-21

2022

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Disruption of Kidney-Immune System Crosstalk in Sepsis with Acute Kidney Injury: Lessons Learned from Animal Models and Their Application to Human Health

International journal of molecular sciences, 2022-02, Vol.23 (3), p.1702

LaFavers, Kaice

2022

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Uromodulin (Tamm–Horsfall protein): guardian of urinary and systemic homeostasis

Nephrology, dialysis, transplantation, 2020-01, Vol.35 (1), p.33-43

2020

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Uromodulin: more than a marker for chronic kidney disease progression

Current opinion in nephrology and hypertension, 2023-05, Vol.32 (3), p.271-277

2023

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Evolving Concepts in Uromodulin Biology, Physiology, and Its Role in Disease: a Tale of Two Forms

A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease

The kidney protects against sepsis by producing systemic uromodulin

Characterization of Plasmodium Atg3-Atg8 Interaction Inhibitors Identifies Novel Alternative Mechanisms of Action in Toxoplasma gondii

Autosomal dominant tubulointerstitial kidney disease: a new tool to guide genetic testing

Systemic Effects of Tamm-Horsfall Protein in Kidney Disease

The kidney releases a nonpolymerizing form of uromodulin in the urine and circulation that retains the external hydrophobic patch domain

Water Loading and Uromodulin Secretion in Healthy Individuals and Idiopathic Calcium Stone Formers

Healthy Women Have Higher Systemic Uromodulin Levels: Identification of Uromodulin as an Estrogen Responsive Gene

Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes

A novel dense granule protein, GRA41, regulates timing of egress and calcium sensitivity in Toxoplasma gondii

Inhibition of Apurinic/Apyrimidinic Endonuclease I’s Redox Activity Revisited

Healthy Women Have Higher Systemic Uromodulin Levels: Identification of Uromodulin as an Estrogen Responsive Gene: FR-PO841

Myeloid Cell Deletion of the Cationic Channel TRPM2, a Target of Uromodulin Inhibition, Is Protective in Murine Sepsis: SA-PO183

Uromodulin Deficiency Shapes AKI Severity by Enhanced Oxidative Injury and Stress Response in Proximal Tubules With Early Activation of the Inflammasome: FR-PO150

The Kidney Produces a Non-Polymerizing Form of Uromodulin That Associates with Reduced Risk of AKI: PO0419

Alternative Splicing Generates an Intracellular Uromodulin Isoform that Mediates Mitochondrial Function and Is Up-Regulated in AKI: FR-PO184

Transcriptomic Profiling of Thick Ascending Limb Cells In Vivo Reveals the Complex Network of Genes Regulated by Uromodulin: PO0629

Variability in Uromodulin Production and Its Response to Water Loading in Healthy Subjects and Patients With Stone Disease: SA-PO170

Detection of Myeloid Cell Pleiotropy In Situ and the Unique Niches of Immune Cells in Ischemic Kidney Injury Using CODEX Imaging: FR-PO149

Uromodulin and Injury Severity Alter Neutrophil Diversity and Signaling in AKI: FR-PO154

A Spatially Anchored Transcriptomic Atlas of the Human Kidney Papilla Identifies Significant Immune Injury and Matrix Remodeling in Stone Disease Patients: FR-OR09

Disruption of Kidney-Immune System Crosstalk in Sepsis with Acute Kidney Injury: Lessons Learned from Animal Models and Their Application to Human Health

Uromodulin (Tamm–Horsfall protein): guardian of urinary and systemic homeostasis

Uromodulin: more than a marker for chronic kidney disease progression

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