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ENHANZE® drug delivery technology: a novel approach to subcutaneous administration using recombinant human hyaluronidase PH20

Drug delivery, 2019-01, Vol.26 (1), p.98-106

2019

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Subcutaneous Delivery of High-Dose/Volume Biologics: Current Status and Prospect for Future Advancements

Drug design, development and therapy, 2021-01, Vol.15, p.159-170

2021

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Parallel Accumulation of Tumor Hyaluronan, Collagen, and Other Drivers of Tumor Progression

Clinical cancer research, 2018-10, Vol.24 (19), p.4798-4807

2018

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Kinetic investigation of recombinant human hyaluronidase PH20 on hyaluronic acid

Analytical biochemistry, 2015-07, Vol.480, p.74-81

2015

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The safety of recombinant human hyaluronidase PH20 in nonclinical models: An overview of toxicology, pharmacology, and impact of anti-PH20 antibodies

Journal of controlled release, 2024-10, Vol.374, p.369-383

2024

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Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors

Cancer research (Chicago, Ill.), 2021-06, Vol.81 (12), p.3319-3332

2021

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Safety of recombinant human hyaluronidase PH20 for subcutaneous drug delivery

Expert opinion on drug delivery, 2021-11, Vol.18 (11), p.1673-1685

2021

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Risk Factors, Hyaluronidase Expression, and Clinical Immunogenicity of Recombinant Human Hyaluronidase PH20, an Enzyme Enabling Subcutaneous Drug Administration

The AAPS journal, 2022-10, Vol.24 (6), p.110-110, Article 110

2022

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Use of computed tomography to assess subcutaneous drug dispersion with recombinant human hyaluronidase PH20 in a swine model

Journal of pharmacological and toxicological methods, 2020-11, Vol.106, p.106936-106936, Article 106936

2020

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Expression of GnTIII in a recombinant anti-CD20 CHO production cell line: Expression of antibodies with altered glycoforms leads to an increase in ADCC through higher affinity for FCγRIII

Biotechnology and bioengineering, 2001-08, Vol.74 (4), p.288-294

2001

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Abstract 2463: PEGPH20 increases the anticancer activity of standard chemotherapy combinations, vincristine (VIN) and D actinomycin (DACT), in a Wilms’ xenograft model

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.2463-2463

2016

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Novel APC-like properties of human NK cells directly regulate T cell activation

The Journal of clinical investigation, 2004-12, Vol.114 (11), p.1612-1623

2004

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Abstract 283: PEGylated recombinant hyaluronidase PH20 (PEGPH20) enhances pemetrexed antitumor efficacy in a human nonsquamous NSCLC xenograft model

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.283-283

2016

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Development and validation of a liquid chromatography method for simultaneous determination of three process-related impurities: yeastolates, triton X-100 and methotrexate

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011-11, Vol.879 (30), p.3612-3619

2011

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Plasma hyaluronan is a predictive marker for pegvorhyaluronidase alfa (PEGPH20; PVHA) response in a phase II study of pancreatic ductal adenocarcinoma (PDAC)

Journal of clinical oncology, 2019-02, Vol.37 (4_suppl), p.404-404

2019

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An Intermediate pH Unfolding Transition Abrogates the Ability of IgE to Interact with Its High Affinity Receptor FcϵRIα

The Journal of biological chemistry, 2006-10, Vol.281 (41), p.30755-30767

2006

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Proteomic analysis of human natural killer cells: insights on new potential NK immune functions

Molecular immunology, 2005-02, Vol.42 (4), p.425-431

2005

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Subcutaneous Delivery of High-Dose/Volume Biologies: Current Status and Prospect for Future Advancements

Drug design, development and therapy, 2021-01, Vol.15, p.159

2021

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Abstract 1755: PEGylated adenosine deaminase (ADA2) prevents adenosine-mediated increase in tumor growth and improves antitumor immune responses

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1755-1755

2018

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Novel APC-like properties of human NK cells directly regulate T cell activation

The Journal of clinical investigation, 2004-12, Vol.114 (11), p.1612-1623

2004

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Novel APC-like properties of human NK cells directly regulate T cell activation

The Journal of clinical investigation, 2015-04, Vol.125 (4), p.1763-1763

2015

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In vitro IgE inhibition in B cells by anti-CD23 monoclonal antibodies is functionally dependent on the immunoglobulin Fc domain

International journal of immunopharmacology, 2000-02, Vol.22 (2), p.131-141

2000

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Covalently linked oxomolybdenum(V) and iron(III) porphyrin centers: Synthetic models for the molybdenum-iron interaction in sulfite oxidase

Journal of the American Chemical Society, 1994-08, Vol.116 (16), p.7166-7176

1994

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Studies of distortional isomers: spectroscopic evidence that green cis,mer-dichlorotris(dimethylphenylphosphine)oxomolybdenum(IV) is a mixture

Journal of the American Chemical Society, 1991-11, Vol.113 (24), p.9193-9200

1991

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Studies of distortional isomers. 2. Evidence that green [LWOCl2]PF6 is a ternary mixture

Inorganic chemistry, 1994-01, Vol.33 (1), p.15-24

1994

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ENHANZE® drug delivery technology: a novel approach to subcutaneous administration using recombinant human hyaluronidase PH20

Subcutaneous Delivery of High-Dose/Volume Biologics: Current Status and Prospect for Future Advancements

Parallel Accumulation of Tumor Hyaluronan, Collagen, and Other Drivers of Tumor Progression

Kinetic investigation of recombinant human hyaluronidase PH20 on hyaluronic acid

The safety of recombinant human hyaluronidase PH20 in nonclinical models: An overview of toxicology, pharmacology, and impact of anti-PH20 antibodies

Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors

Safety of recombinant human hyaluronidase PH20 for subcutaneous drug delivery

Risk Factors, Hyaluronidase Expression, and Clinical Immunogenicity of Recombinant Human Hyaluronidase PH20, an Enzyme Enabling Subcutaneous Drug Administration

Use of computed tomography to assess subcutaneous drug dispersion with recombinant human hyaluronidase PH20 in a swine model

Expression of GnTIII in a recombinant anti-CD20 CHO production cell line: Expression of antibodies with altered glycoforms leads to an increase in ADCC through higher affinity for FCγRIII

Abstract 2463: PEGPH20 increases the anticancer activity of standard chemotherapy combinations, vincristine (VIN) and D actinomycin (DACT), in a Wilms’ xenograft model

Novel APC-like properties of human NK cells directly regulate T cell activation

Abstract 283: PEGylated recombinant hyaluronidase PH20 (PEGPH20) enhances pemetrexed antitumor efficacy in a human nonsquamous NSCLC xenograft model

Development and validation of a liquid chromatography method for simultaneous determination of three process-related impurities: yeastolates, triton X-100 and methotrexate

Plasma hyaluronan is a predictive marker for pegvorhyaluronidase alfa (PEGPH20; PVHA) response in a phase II study of pancreatic ductal adenocarcinoma (PDAC)

An Intermediate pH Unfolding Transition Abrogates the Ability of IgE to Interact with Its High Affinity Receptor FcϵRIα

Proteomic analysis of human natural killer cells: insights on new potential NK immune functions

Subcutaneous Delivery of High-Dose/Volume Biologies: Current Status and Prospect for Future Advancements

Abstract 1755: PEGylated adenosine deaminase (ADA2) prevents adenosine-mediated increase in tumor growth and improves antitumor immune responses

Novel APC-like properties of human NK cells directly regulate T cell activation

Novel APC-like properties of human NK cells directly regulate T cell activation

In vitro IgE inhibition in B cells by anti-CD23 monoclonal antibodies is functionally dependent on the immunoglobulin Fc domain

Covalently linked oxomolybdenum(V) and iron(III) porphyrin centers: Synthetic models for the molybdenum-iron interaction in sulfite oxidase

Studies of distortional isomers: spectroscopic evidence that green cis,mer-dichlorotris(dimethylphenylphosphine)oxomolybdenum(IV) is a mixture

Studies of distortional isomers. 2. Evidence that green [LWOCl2]PF6 is a ternary mixture

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