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HuR modulation counteracts lipopolysaccharide response in murine macrophages

Disease models & mechanisms, 2023-03, Vol.16 (3)

2023

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Receptor-Bound Conformation of Cilengitide Better Represented by Its Solution-State Structure than the Solid-State Structure

Chemistry : a European journal, 2014-10, Vol.20 (44), p.14201-14206

2014

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Editorial: Promising tools in targeted cancer therapy

Archiv der Pharmazie (Weinheim), 2024-08, Vol.357 (8), p.e2400408-n/a

2024

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A Novel Cell-Permeable, Selective, and Noncompetitive Inhibitor of KAT3 Histone Acetyltransferases from a Combined Molecular Pruning/Classical Isosterism Approach

Journal of medicinal chemistry, 2015-03, Vol.58 (6), p.2779-2798

2015

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A combined approach of structure‐based virtual screening and NMR to interrupt the PD‐1/PD‐L1 axis: Biphenyl‐benzimidazole containing compounds as novel PD‐L1 inhibitors

Archiv der Pharmazie (Weinheim), 2024-03, Vol.357 (3), p.e2300583-n/a

2024

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Discovery of Covalent Inhibitors of Glyceraldehyde-3-phosphate Dehydrogenase, A Target for the Treatment of Malaria

Journal of medicinal chemistry, 2014-09, Vol.57 (17), p.7465-7471

2014

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Progresses in the pursuit of aldose reductase inhibitors: The structure-based lead optimization step

European journal of medicinal chemistry, 2012-05, Vol.51, p.216-226

2012

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Best Matching Protein Conformations and Docking Programs for a Virtual Screening Campaign Against SMO Receptor

Molecular informatics, 2016-09, Vol.35 (8-9), p.340-349

2016

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Protein Flexibility in Virtual Screening: The BACE‑1 Case Study

Journal of chemical information and modeling, 2012-10, Vol.52 (10), p.2697-2704

2012

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Identification of a Novel p53 Modulator Endowed with Antitumoural and Antibacterial Activity through a Scaffold Repurposing Approach

Pharmaceuticals (Basel, Switzerland), 2022-10, Vol.15 (11), p.1318

2022

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Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design

Computational and structural biotechnology journal, 2023-01, Vol.21, p.3355-3368

2023

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State-of-the-art methodologies for the discovery and characterization of DNA G-quadruplex binders

Current pharmaceutical design, 2012-05, Vol.18 (14), p.1880

2012

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A stereoselective approach to peptidomimetic BACE1 inhibitors

European journal of medicinal chemistry, 2013-12, Vol.70, p.233-247

2013

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Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors

European journal of medicinal chemistry, 2011-07, Vol.46 (7), p.2617-2629

2011

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Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies

Journal of medicinal chemistry, 2011-03, Vol.54 (5), p.1401-1420

2011

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Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5‑Fluorouracil Nucleolar Stress in Colorectal Cancer Cells

Journal of medicinal chemistry, 2024-02, Vol.67 (3), p.1812-1824

2024

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Interfering with the Tumor–Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors

Journal of medicinal chemistry, 2021-11, Vol.64 (21), p.16020-16045

2021

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HuR-targeted agents: An insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models

Advanced drug delivery reviews, 2022-02, Vol.181, p.114088-114088, Article 114088

2022

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Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis

European journal of medicinal chemistry, 2020-02, Vol.188, p.112006, Article 112006

2020

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Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts

Biochimica et biophysica acta. Molecular cell research, 2019-05, Vol.1866 (5), p.737-749

2019

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CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme

European journal of pharmacology, 2021-04, Vol.897, p.173936-173936, Article 173936

2021

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Design, Synthesis, and Biological Evaluation of 1‑Phenylpyrazolo[3,4‑e]pyrrolo[3,4‑g]indolizine-4,6(1H,5H)‑diones as New Glycogen Synthase Kinase-3β Inhibitors

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.10066-10078

2013

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Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure–Activity Relationship Studies and Pharmacological Activity

Journal of medicinal chemistry, 2017-10, Vol.60 (19), p.8115-8130

2017

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Apoptosis therapy in cancer: the first single-molecule co-activating p53 and the translocator protein in glioblastoma

Scientific reports, 2014-04, Vol.4 (1), p.4749-4749, Article 4749

2014

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Lead Optimization of 2‑Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4526-4538

2016

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HuR modulation counteracts lipopolysaccharide response in murine macrophages

Receptor-Bound Conformation of Cilengitide Better Represented by Its Solution-State Structure than the Solid-State Structure

Editorial: Promising tools in targeted cancer therapy

A Novel Cell-Permeable, Selective, and Noncompetitive Inhibitor of KAT3 Histone Acetyltransferases from a Combined Molecular Pruning/Classical Isosterism Approach

A combined approach of structure‐based virtual screening and NMR to interrupt the PD‐1/PD‐L1 axis: Biphenyl‐benzimidazole containing compounds as novel PD‐L1 inhibitors

Discovery of Covalent Inhibitors of Glyceraldehyde-3-phosphate Dehydrogenase, A Target for the Treatment of Malaria

Progresses in the pursuit of aldose reductase inhibitors: The structure-based lead optimization step

Best Matching Protein Conformations and Docking Programs for a Virtual Screening Campaign Against SMO Receptor

Protein Flexibility in Virtual Screening: The BACE‑1 Case Study

Identification of a Novel p53 Modulator Endowed with Antitumoural and Antibacterial Activity through a Scaffold Repurposing Approach

Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design

State-of-the-art methodologies for the discovery and characterization of DNA G-quadruplex binders

A stereoselective approach to peptidomimetic BACE1 inhibitors

Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors

Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies

Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5‑Fluorouracil Nucleolar Stress in Colorectal Cancer Cells

Interfering with the Tumor–Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors

HuR-targeted agents: An insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models

Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis

Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts

CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme

Design, Synthesis, and Biological Evaluation of 1‑Phenylpyrazolo[3,4‑e]pyrrolo[3,4‑g]indolizine-4,6(1H,5H)‑diones as New Glycogen Synthase Kinase-3β Inhibitors

Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure–Activity Relationship Studies and Pharmacological Activity

Apoptosis therapy in cancer: the first single-molecule co-activating p53 and the translocator protein in glioblastoma

Lead Optimization of 2‑Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas

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