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Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

Nature medicine, 2007-09, Vol.13 (9), p.1102-1107

2007

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Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

The Journal of neuroscience, 2011-11, Vol.31 (46), p.16507-16516

2011

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Safety, tolerability, and pharmacokinetic evaluation of single- and multiple-ascending doses of a novel kappa opioid receptor antagonist LY2456302 and drug interaction with ethanol in healthy subjects

Journal of clinical pharmacology, 2014-09, Vol.54 (9), p.968-978

2014

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Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.8076-8100

2021

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Safety, Tolerability, and Pharmacokinetics of Zagotenemab in Participants with Symptomatic Alzheimer’s Disease: A Phase I Clinical Trial

JAD reports, 2023-01, Vol.7 (1), p.1015-1024

2023

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Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human

The international journal of neuropsychopharmacology, 2015-01, Vol.18 (2), p.1-11

2015

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Theoretical UV Circular Dichroism of Aliphatic Cyclic Dipeptides

The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory, 2005-06, Vol.109 (24), p.5463-5470

2005

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Brownian dynamics simulations of the interactions between lactate dehydrogenase (LDH) and G- or F-Actin. Part I: Muscle and heart homo-isoforms

Scientific African, 2020-09, Vol.9, p.e00510, Article e00510

2020

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Robust Pharmacodynamic Effect of LY3202626, a Central Nervous System Penetrant, Low Dose BACE1 Inhibitor, in Humans and Nonclinical Species

JAD reports, 2022-01, Vol.6 (1), p.1-15

2022

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Validation of a multiplex assay for simultaneous quantification of amyloid-β peptide species in human plasma with utility for measurements in studies of Alzheimer's disease therapeutics

Journal of Alzheimer's disease, 2012-01, Vol.32 (4), p.905

2012

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SAFETY, PHARMACOKINETICS (PK), AND FLORBETAPIR F-18 POSITRON EMISSION TOMOGRAPHY (PET) AFTER MULTIPLE DOSE ADMINISTRATION OF LY3002813, A β-AMYLOID PLAQUE-SPECIFIC ANTIBODY, IN ALZHEIMER’S DISEASE (AD)

Alzheimer's & dementia, 2016-07, Vol.12 (7), p.P352-P353

2016

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Glycolytic Enzyme Interactions with Yeast and Skeletal Muscle F-Actin

Biophysical journal, 2006-02, Vol.90 (4), p.1371-1384

2006

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The effects on metabolic clearance when administering a potent CYP3A autoinducer with the prototypic CYP3A inhibitor, ketoconazole

Drug metabolism and disposition, 2012-10, Vol.40 (10), p.1945

2012

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Adverse Events in Healthy Subjects Exposed to Single and Multiple Doses of LY2140023 Monohydrate: Pooled Results From 10 Phase 1 Studies

Journal of clinical psychopharmacology, 2012-06, Vol.32 (3), p.408-411

2012

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Semagacestat Pharmacokinetics Are Not Significantly Affected by Formulation, Food, or Time of Dosing in Healthy Participants

Journal of clinical pharmacology, 2012-06, Vol.52 (6), p.904-913

2012

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Identification of specific calcitonin-like receptor residues important for calcitonin gene-related peptide high affinity binding

BMC pharmacology, 2006-06, Vol.6 (1), p.9-9, Article 9

2006

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A COMPARISON OF IN VIVO POTENCY IN TWO BACE INHIBITORS AS DETERMINED IN HUMANS AND DOGS

Alzheimer's & dementia, 2014-07, Vol.10 (4), p.P448-P448

2014

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Cortisol response to individualised graded insulin infusions: a reproducible biomarker for CNS compounds inhibiting HPA activation

British journal of clinical pharmacology, 2010-12, Vol.70 (6), p.886-894

2010

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Theoretical UV Circular Dichroism of Cyclo(l-Proline-l-Proline)

The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory, 2006-02, Vol.110 (5), p.1925-1933

2006

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l-5-Hydroxytryptophan augments the neuroendocrine response to a SSRI

Psychoneuroendocrinology, 2006-05, Vol.31 (4), p.473-484

2006

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Theoretical study of interactions between muscle aldolase and F-actin: Insight into different species

Biopolymers, 2007-01, Vol.85 (1), p.60-71

2007

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Pharmacokinetics of ruboxistaurin are significantly altered by rifampicin‐mediated CYP3A4 induction

British journal of clinical pharmacology, 2006-02, Vol.61 (2), p.200-210

2006

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Safety and efficacy of alamifovir in patients with chronic hepatitis B virus infection

Journal of hepatology, 2004-11, Vol.41 (5), p.852-858

2004

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Theoretical UV Circular Dichroism of Cyclo(l-Proline-l-Proline)

The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory, 2006-05, Vol.110 (17), p.5965-5965

2006

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Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans

Safety, tolerability, and pharmacokinetic evaluation of single- and multiple-ascending doses of a novel kappa opioid receptor antagonist LY2456302 and drug interaction with ethanol in healthy subjects

Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor

Safety, Tolerability, and Pharmacokinetics of Zagotenemab in Participants with Symptomatic Alzheimer’s Disease: A Phase I Clinical Trial

Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human

Theoretical UV Circular Dichroism of Aliphatic Cyclic Dipeptides

Brownian dynamics simulations of the interactions between lactate dehydrogenase (LDH) and G- or F-Actin. Part I: Muscle and heart homo-isoforms

Robust Pharmacodynamic Effect of LY3202626, a Central Nervous System Penetrant, Low Dose BACE1 Inhibitor, in Humans and Nonclinical Species

Validation of a multiplex assay for simultaneous quantification of amyloid-β peptide species in human plasma with utility for measurements in studies of Alzheimer's disease therapeutics

SAFETY, PHARMACOKINETICS (PK), AND FLORBETAPIR F-18 POSITRON EMISSION TOMOGRAPHY (PET) AFTER MULTIPLE DOSE ADMINISTRATION OF LY3002813, A β-AMYLOID PLAQUE-SPECIFIC ANTIBODY, IN ALZHEIMER’S DISEASE (AD)

Glycolytic Enzyme Interactions with Yeast and Skeletal Muscle F-Actin

The effects on metabolic clearance when administering a potent CYP3A autoinducer with the prototypic CYP3A inhibitor, ketoconazole

Adverse Events in Healthy Subjects Exposed to Single and Multiple Doses of LY2140023 Monohydrate: Pooled Results From 10 Phase 1 Studies

Semagacestat Pharmacokinetics Are Not Significantly Affected by Formulation, Food, or Time of Dosing in Healthy Participants

Identification of specific calcitonin-like receptor residues important for calcitonin gene-related peptide high affinity binding

A COMPARISON OF IN VIVO POTENCY IN TWO BACE INHIBITORS AS DETERMINED IN HUMANS AND DOGS

Cortisol response to individualised graded insulin infusions: a reproducible biomarker for CNS compounds inhibiting HPA activation

Theoretical UV Circular Dichroism of Cyclo(l-Proline-l-Proline)

l-5-Hydroxytryptophan augments the neuroendocrine response to a SSRI

Theoretical study of interactions between muscle aldolase and F-actin: Insight into different species

Pharmacokinetics of ruboxistaurin are significantly altered by rifampicin‐mediated CYP3A4 induction

Safety and efficacy of alamifovir in patients with chronic hepatitis B virus infection

Theoretical UV Circular Dichroism of Cyclo(l-Proline-l-Proline)

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