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The transcriptional program, functional heterogeneity, and clinical targeting of mast cells

The Journal of experimental medicine, 2017-09, Vol.214 (9), p.2491-2506

2017

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The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling

Immunological reviews, 2012-11, Vol.250 (1), p.277-302

2012

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Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia

Nature communications, 2021-11, Vol.12 (1), p.6436-20, Article 6436

2021

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Mechanisms of vitamin D3 metabolite repression of IgE-dependent mast cell activation

Journal of allergy and clinical immunology, 2014-05, Vol.133 (5), p.1356-1364.e14

2014

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The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

Blood, 2009-08, Vol.114 (7), p.1289-1298

2009

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Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling

Structure (London), 2016-08, Vol.24 (8), p.1271-1281

2016

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Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Blood, 2017-02, Vol.129 (6), p.771-782

2017

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The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

Cell, 2008-08, Vol.134 (3), p.496-507

2008

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Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models

Cell death & disease, 2022-02, Vol.13 (2), p.137-137, Article 137

2022

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14-3-3ζ coordinates adipogenesis of visceral fat

Nature communications, 2015-07, Vol.6 (1), p.7671, Article 7671

2015

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14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

Nature communications, 2016-09, Vol.7 (1), p.12862-12862, Article 12862

2016

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The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation

Nature communications, 2016-10, Vol.7 (1), p.13198-13198, Article 13198

2016

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A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Nature communications, 2018-01, Vol.9 (1), p.386-15, Article 386

2018

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Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice

Haematologica (Roma), 2015-07, Vol.100 (7), p.914-926

2015

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Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

Cell reports (Cambridge), 2014-07, Vol.8 (2), p.410-419

2014

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A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis

Developmental cell, 2015-12, Vol.35 (6), p.759-774

2015

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Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis

Science advances, 2018-11, Vol.4 (11), p.eaat3834

2018

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Cytokine receptor activation at the cell surface

Current opinion in structural biology, 2012-06, Vol.22 (3), p.350-359

2012

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14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance

Molecular metabolism (Germany), 2020-11, Vol.41, p.101052-101052, Article 101052

2020

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High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties

PloS one, 2013-08, Vol.8 (8), p.e74376-e74376

2013

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Understanding mast cell heterogeneity at single cell resolution

Trends in immunology, 2021-06, Vol.42 (6), p.523-535

2021

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Molecular basis of cytokine receptor activation

IUBMB life, 2010-07, Vol.62 (7), p.509-518

2010

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Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract

Blood advances, 2019-10, Vol.3 (19), p.2859-2865

2019

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Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer

Oncoimmunology, 2017-10, Vol.6 (10), p.e1331195-e1331195

2017

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The transcriptional program, functional heterogeneity, and clinical targeting of mast cells

The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling

Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia

Mechanisms of vitamin D3 metabolite repression of IgE-dependent mast cell activation

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models

14-3-3ζ coordinates adipogenesis of visceral fat

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis

Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis

Cytokine receptor activation at the cell surface

TLR7 gain-of-function genetic variation causes human lupus

14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance

High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties

Understanding mast cell heterogeneity at single cell resolution

Molecular basis of cytokine receptor activation

Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract

Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer

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