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Phospholipases A2: Unveiling the secrets of a functionally versatile group of snake venom toxins

Toxicon (Oxford), 2013-02, Vol.62, p.27-39

2013

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Strategies in 'snake venomics' aiming at an integrative view of compositional, functional, and immunological characteristics of venoms

The journal of venomous animals and toxins including tropical diseases, 2017-04, Vol.23 (1), p.26-26, Article 26

2017

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Lys49 myotoxins, secreted phospholipase A2-like proteins of viperid venoms: A comprehensive review

Toxicon (Oxford), 2023-03, Vol.224, p.107024-107024, Article 107024

Lomonte, Bruno

2023

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Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species

Nature communications, 2019-08, Vol.10 (1), p.3642-8, Article 3642

2019

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Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus

Scientific reports, 2021-09, Vol.11 (1), p.19452-16, Article 19452

2021

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Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms

Toxins, 2020-02, Vol.12 (2), p.131

2020

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High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches

PLoS neglected tropical diseases, 2020-04, Vol.14 (4), p.e0007802-e0007802

2020

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Venoms, venomics, antivenomics

FEBS letters, 2009-06, Vol.583 (11), p.1736-1743

2009

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In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

Nature communications, 2018-10, Vol.9 (1), p.3928-9, Article 3928

2018

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Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes

Nature communications, 2023-02, Vol.14 (1), p.682-682, Article 682

2023

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Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score

Toxicon (Oxford), 2015-09, Vol.104, p.43-45

2015

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From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy

Current pharmaceutical design, 2016-01, Vol.22 (34), p.5270-5293

2016

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Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo

PloS one, 2014-10, Vol.9 (10), p.e109846

2014

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Toxicovenomics and antivenom profiling of the Eastern green mamba snake (Dendroaspis angusticeps)

Journal of proteomics, 2016-03, Vol.136, p.248-261

2016

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Antivenomics and in vivo preclinical efficacy of six Latin American antivenoms towards south-western Colombian Bothrops asper lineage venoms

PLoS neglected tropical diseases, 2021-02, Vol.15 (2), p.e0009073

2021

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Phospholipase A2 isolated from the venom of Crotalus durissus terrificus inactivates dengue virus and other enveloped viruses by disrupting the viral envelope

PloS one, 2014-11, Vol.9 (11), p.e112351

2014

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Preclinical Evaluation of the Efficacy of Antivenoms for Snakebite Envenoming: State-of-the-Art and Challenges Ahead

Toxins, 2017-05, Vol.9 (5), p.163

2017

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SDS-induced hexameric oligomerization of myotoxin-II from Bothrops asper assessed by sedimentation velocity and nuclear magnetic resonance

European biophysics journal, 2023-07, Vol.52 (4-5), p.445-457

2023

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Purification and characterization of the first γ-phospholipase inhibitor (γPLI) from Bothrops jararaca snake serum

PloS one, 2018-03, Vol.13 (3), p.e0193105-e0193105

2018

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Innovative Immunization Strategies for Antivenom Development

Toxins, 2018-11, Vol.10 (11), p.452

2018

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Bee venom phospholipase A2 protects against acetaminophen-induced acute liver injury by modulating regulatory T cells and IL-10 in mice

PloS one, 2014-12, Vol.9 (12), p.e114726

2014

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Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing

BMC genomics, 2011-05, Vol.12 (1), p.259-259, Article 259

2011

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Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper

Nature communications, 2024-01, Vol.15 (1), p.173-173, Article 173

2024

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Novel Snakebite Therapeutics Must Be Tested in Appropriate Rescue Models to Robustly Assess Their Preclinical Efficacy

Toxins, 2020-08, Vol.12 (9), p.528

2020

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Phospholipases A2: Unveiling the secrets of a functionally versatile group of snake venom toxins

Strategies in 'snake venomics' aiming at an integrative view of compositional, functional, and immunological characteristics of venoms

Lys49 myotoxins, secreted phospholipase A2-like proteins of viperid venoms: A comprehensive review

Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species

Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus

Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms

High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches

Venoms, venomics, antivenomics

In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes

Inhibition of the Myotoxicity Induced by Bothrops jararacussu Venom and Isolated Phospholipases A2 by Specific Camelid Single-Domain Antibody Fragments

Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score

From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy

Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo

Toxicovenomics and antivenom profiling of the Eastern green mamba snake (Dendroaspis angusticeps)

Antivenomics and in vivo preclinical efficacy of six Latin American antivenoms towards south-western Colombian Bothrops asper lineage venoms

Phospholipase A2 isolated from the venom of Crotalus durissus terrificus inactivates dengue virus and other enveloped viruses by disrupting the viral envelope

Preclinical Evaluation of the Efficacy of Antivenoms for Snakebite Envenoming: State-of-the-Art and Challenges Ahead

SDS-induced hexameric oligomerization of myotoxin-II from Bothrops asper assessed by sedimentation velocity and nuclear magnetic resonance

Purification and characterization of the first γ-phospholipase inhibitor (γPLI) from Bothrops jararaca snake serum

Innovative Immunization Strategies for Antivenom Development

Bee venom phospholipase A2 protects against acetaminophen-induced acute liver injury by modulating regulatory T cells and IL-10 in mice

Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing

Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper

Novel Snakebite Therapeutics Must Be Tested in Appropriate Rescue Models to Robustly Assess Their Preclinical Efficacy

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