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301 OMX-0407, a highly potent SIK3 inhibitor, sensitizes tumor cells to apoptosis and eradicates tumors in combination with PD-1 inhibition

Journal for immunotherapy of cancer, 2021-11, Vol.9 (Suppl 2), p.A324-A324

2021

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60 Development of a gene signature to predict the anti-tumor response of the salt-inducible kinase (SIK) inhibitor OMX-0407

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A70-A70

2023

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Prediction of Mechanisms of Action of Antibacterial Compounds by Gene Expression Profiling

Antimicrobial Agents and Chemotherapy, 2004-08, Vol.48 (8), p.2838-2844

2004

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Panel of Bacillus subtilis Reporter Strains Indicative of Various Modes of Action

Antimicrobial Agents and Chemotherapy, 2004-07, Vol.48 (7), p.2588-2594

2004

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A genome-based approach for the identification of essential bacterial genes

Nature biotechnology, 1998-09, Vol.16 (9), p.851-856

1998

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Abstract 6698: A first-in-class SIK3 inhibitor, OMX-0370, effectively inhibits tumor growth in syngeneic tumor models, as single agent, by abolishing tumor resistance to immune-derived TNF

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.6698-6698

2020

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Identification by RNA Profiling and Mutational Analysis of the Novel Copper Resistance Determinants CrdA (HP1326), CrdB (HP1327), and CzcB (HP1328) in Helicobacter pylori

Journal of Bacteriology, 2002-12, Vol.184 (23), p.6700-6708

2002

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Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs

Leukemia, 2013-12, Vol.27 (12), p.2366-2375

2013

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Abstract 953: Development of a predictive biomarker signature for the highly potent SIK3 inhibitor OMX-0407

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.953-953

2023

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Abstract 514: Salt-inducible kinase inhibitor OMX-0407 drives cell-cycle arrest in vitro and in vivo: An in-depth MoA analysis by phospho-proteomics

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.514-514

2024

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Abstract 3708: OMX-0407, a highly potent SIK3 inhibitor, sensitizes tumor cells to cell death and eradicates tumors in combination with PD-1 inhibition

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.3708-3708

2022

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Abstract 1362: IOMX-0675, a LILRB1 and LILRB2 cross-specific antibody, effectively repolarizes immunosuppressive myeloid cells and activates T cells leading to potent tumor cell killing

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.1362-1362

2024

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Computational Analysis of Genomic Abnormalities from a Phase 3 Trial of Rigosertib in Higher-Risk MDS: Simulation of a Predictive Signature for Clinical Response

Blood, 2016-12, Vol.128 (22), p.4324-4324

2016

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A Bacterial Thioredoxin-like Protein That Is Exposed to the Periplasm Has Redox Properties Comparable with Those of Cytoplasmic Thioredoxins (∗)

The Journal of biological chemistry, 1995-11, Vol.270 (44), p.26178-26183

1995

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Phase I study of RGB-286638, a novel, multitargeted cyclin-dependent kinase inhibitor in patients with solid tumors

Clinical cancer research, 2014-09, Vol.20 (18), p.4776-4783

2014

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Abstract B43: Determination of biomarkers responsible for sensitivity and resistance of RGB-286638 action in vitro

Molecular cancer therapeutics, 2009-12, Vol.8 (12_Supplement), p.B43-B43

2009

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Availability of the fibre subunit CsgA and the nucleator protein CsgB during assembly of fibronectin‐binding curli is limited by the intracellular concentration of the novel lipoprotein CsgG

Molecular microbiology, 1997-10, Vol.26 (1), p.11-23

1997

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EcfE, a new essential inner membrane protease: its role in the regulation of heat shock response in Escherichia coli

The EMBO journal, 2001-11, Vol.20 (21), p.5908-5918

2001

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Overcoming p53 Loss with a Multi-Targeted Small Molecule Inhibitor in Multiple Myeloma

Blood, 2009-11, Vol.114 (22), p.4915-4915

2009

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RGB 286638, a Novel Multi-Targeted Small Molecule Inhibitor, Induces Multiple Myeloma (MM) Cell Death through Abrogation of CDKDependent and Independent Survival Mechanisms

Blood, 2008-11, Vol.112 (11), p.2759-2759

2008

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Protein disulphide oxidoreductases in bacteria

Trends in Biochemical Sciences, 1994-04, Vol.19 (4), p.169-171

1994

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DNA microarray technology and antimicrobial drug discovery

Pharmacogenomics, 2000-05, Vol.1 (2), p.169-178

2000

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Integrated bacterial genomics for the discovery of novel antimicrobials

Drug Discovery Today, 2000-03, Vol.5 (3), p.107-114

2000

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Mining bacterial genomes for antimicrobial targets

Molecular Medicine Today, 2000-12, Vol.6 (12), p.470-474

Loferer, Hannes

2000

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Automatische Inspektion statt manueller Sichtkontrolle: Makellose Lackoberflächen

JOT Journal für Oberflächentechnik, 2016-03, Vol.56 (3), p.66-67

Loferer, Hannes

2016

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301 OMX-0407, a highly potent SIK3 inhibitor, sensitizes tumor cells to apoptosis and eradicates tumors in combination with PD-1 inhibition

60 Development of a gene signature to predict the anti-tumor response of the salt-inducible kinase (SIK) inhibitor OMX-0407

Prediction of Mechanisms of Action of Antibacterial Compounds by Gene Expression Profiling

Panel of Bacillus subtilis Reporter Strains Indicative of Various Modes of Action

A genome-based approach for the identification of essential bacterial genes

Abstract 6698: A first-in-class SIK3 inhibitor, OMX-0370, effectively inhibits tumor growth in syngeneic tumor models, as single agent, by abolishing tumor resistance to immune-derived TNF

Identification by RNA Profiling and Mutational Analysis of the Novel Copper Resistance Determinants CrdA (HP1326), CrdB (HP1327), and CzcB (HP1328) in Helicobacter pylori

Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs

Abstract 953: Development of a predictive biomarker signature for the highly potent SIK3 inhibitor OMX-0407

Abstract 514: Salt-inducible kinase inhibitor OMX-0407 drives cell-cycle arrest in vitro and in vivo: An in-depth MoA analysis by phospho-proteomics

Abstract 3708: OMX-0407, a highly potent SIK3 inhibitor, sensitizes tumor cells to cell death and eradicates tumors in combination with PD-1 inhibition

Abstract 1362: IOMX-0675, a LILRB1 and LILRB2 cross-specific antibody, effectively repolarizes immunosuppressive myeloid cells and activates T cells leading to potent tumor cell killing

Computational Analysis of Genomic Abnormalities from a Phase 3 Trial of Rigosertib in Higher-Risk MDS: Simulation of a Predictive Signature for Clinical Response

A Bacterial Thioredoxin-like Protein That Is Exposed to the Periplasm Has Redox Properties Comparable with Those of Cytoplasmic Thioredoxins (∗)

Phase I study of RGB-286638, a novel, multitargeted cyclin-dependent kinase inhibitor in patients with solid tumors

Abstract B43: Determination of biomarkers responsible for sensitivity and resistance of RGB-286638 action in vitro

Availability of the fibre subunit CsgA and the nucleator protein CsgB during assembly of fibronectin‐binding curli is limited by the intracellular concentration of the novel lipoprotein CsgG

EcfE, a new essential inner membrane protease: its role in the regulation of heat shock response in Escherichia coli

Overcoming p53 Loss with a Multi-Targeted Small Molecule Inhibitor in Multiple Myeloma

RGB 286638, a Novel Multi-Targeted Small Molecule Inhibitor, Induces Multiple Myeloma (MM) Cell Death through Abrogation of CDKDependent and Independent Survival Mechanisms

Protein disulphide oxidoreductases in bacteria

DNA microarray technology and antimicrobial drug discovery

Integrated bacterial genomics for the discovery of novel antimicrobials

Mining bacterial genomes for antimicrobial targets

Automatische Inspektion statt manueller Sichtkontrolle: Makellose Lackoberflächen

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