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The Precautionary Principle in Environmental Science

Environmental health perspectives, 2001-09, Vol.109 (9), p.871-876

2001

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Genetic Effects of Thymine Glycol: Site-Specific Mutagenesis and Molecular Modeling Studies

Proceedings of the National Academy of Sciences - PNAS, 1989-10, Vol.86 (20), p.7677-7681

1989

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Mutagenesis by the (+)-anti-diol epoxide of benzo[a]pyrene: What controls mutagenic specificity?

Biochemistry (Easton), 1993-02, Vol.32 (7), p.1759-1769

1993

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Mutational specificity of the (+)-anti-diol epoxide of benzo[a]pyrene in a supF gene of an Escherichia coli plasmid: DNA sequence context influences hotspots, mutagenic specificity and the extent of SOS enhancement of mutagenesis

Carcinogenesis (New York), 1993-03, Vol.14 (3), p.373-383

1993

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Molecular modeling of the major adduct of (+)-anti-B[a]PDE (N2-dG) in the eight conformations and the five DNA sequences most relevant to base substitution mutagenesis

Carcinogenesis (New York), 1999-01, Vol.20 (1), p.85-94

1999

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Mutagenesis by (+)-anti-B[α]P-N2-Gua, the major adduct of activated benzo[α]pyrene, when studied in an Escherichia coli plasmid using site-directed methods

Carcinogenesis (New York), 1992-08, Vol.13 (8), p.1415-1425

1992

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A hypothesis for what conformation of the major adduct of (+)-anti-B[a]PDE (N2-dG) causes G→T versus G→A mutations based upon a correlation between mutagenesis and molecular modeling results

Carcinogenesis (New York), 1999-01, Vol.20 (1), p.95-102

1999

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DNA polymerase II (polB) is involved in a new DNA repair pathway for DNA interstrand cross-links in Escherichia coli

Journal of bacteriology, 1999-05, Vol.181 (9), p.2878-2882

1999

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Molecular modeling of the conformational complexity of (+)-anti-B[α]PDE-adducted DNA using simulated annealing

Carcinogenesis (New York), 1997-08, Vol.18 (8), p.1585-1593

1997

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Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens

Mutation research, 2000-10, Vol.463 (3), p.215-246

2000

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DNA guanine-guanine crosslinking sequence specificity of isophosphoramide mustard, the alkylating metabolite of the clinical antitumor agent ifosfamide

Cancer chemotherapy and pharmacology, 2000-01, Vol.45 (1), p.59-62

2000

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How are potent bulky carcinogens able to induce such a diverse array of mutations?

Molecular carcinogenesis, 1995-08, Vol.13 (4), p.213-219

Loechler, Edward L.

1995

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The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: perspective, prospects and problems

Carcinogenesis (New York), 1996-05, Vol.17 (5), p.895-902

Loechler, E L

1996

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Synthesis of a duplex oligonucleotide containing a nitrogen mustard interstrand DNA-DNA cross-link

Cancer research (Chicago, Ill.), 1989-12, Vol.49 (23), p.6529-6537

1989

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Mapping the binding site of aflatoxin B1 in DNA: systematic analysis of the reactivity of aflatoxin B1 with guanines in different DNA sequences

Biochemistry (Easton), 1988-01, Vol.27 (1), p.472-481

1988

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AP sites are not significantly involved in mutagenesis by the (+)anti diol epoxide of benzo[a]pyrene : the complexity of its mutagenic specificity is likely to arise from adduct conformational polymorphism

Biochemistry (Easton), 1993-07, Vol.32 (26), p.6555-6562

1993

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A violation of the Swain-Scott principle, and not SN1 versus SN2 reaction mechanisms, explains why carcinogenic alkylating agents can form different proportions of adducts at oxygen versus nitrogen in DNA

Chemical research in toxicology, 1994-05, Vol.7 (3), p.277-280

LOECHLER, E. L

1994

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Evidence for a Recombination-Independent Pathway for the Repair of DNA Interstrand Cross-Links Based on a Site-Specific Study with Nitrogen Mustard

Biochemistry (Easton), 1997-03, Vol.36 (12), p.3506-3513

1997

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[23] Molecular modeling in mutagenesis and carcinogenesis

Methods in Enzymology, 1991, Vol.203, p.458-476

Loechler, Edward L.

1991

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Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells

Nucleic acids research, 2006-01, Vol.34 (9), p.2845-2845

2006

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Sequence Specific Mutagenesis of the Major (+)-anti-Benzo[a]pyrene Diol Epoxide−DNA Adduct at a Mutational Hot Spot in Vitro and in Escherichia coli Cells

Chemical research in toxicology, 1997-04, Vol.10 (4), p.369-377

1997

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Evidence from in vitro Replication that O6-Methylguanine can Adopt Multiple Conformations

Proceedings of the National Academy of Sciences - PNAS, 1993-05, Vol.90 (9), p.3983-3987

1993

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Construction of a human shuttle vector containing a single nitrogen mustard interstrand, DNA-DNA cross-link at a unique plasmid location

Cancer research (Chicago, Ill.), 1991-05, Vol.51 (9), p.2268-2272

1991

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Construction of Escherichia coli vectors containing deoxyadenosine and deoxyguanosine adducts from (+)-anti-dibenz[a,j]anthracene diol epoxide at a defined site

Chemical research in toxicology, 1993-09, Vol.6 (5), p.681-689

1993

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The major, N2-dG adduct of (+)-anti-B[a]PDE induces G→A mutations in a 5'-AGA-3' sequence context

Carcinogenesis (New York), 1999-02, Vol.20 (2), p.261-268

1999

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The Precautionary Principle in Environmental Science

Genetic Effects of Thymine Glycol: Site-Specific Mutagenesis and Molecular Modeling Studies

Mutagenesis by the (+)-anti-diol epoxide of benzo[a]pyrene: What controls mutagenic specificity?

Mutational specificity of the (+)-anti-diol epoxide of benzo[a]pyrene in a supF gene of an Escherichia coli plasmid: DNA sequence context influences hotspots, mutagenic specificity and the extent of SOS enhancement of mutagenesis

Molecular modeling of the major adduct of (+)-anti-B[a]PDE (N2-dG) in the eight conformations and the five DNA sequences most relevant to base substitution mutagenesis

Mutagenesis by (+)-anti-B[α]P-N2-Gua, the major adduct of activated benzo[α]pyrene, when studied in an Escherichia coli plasmid using site-directed methods

A hypothesis for what conformation of the major adduct of (+)-anti-B[a]PDE (N2-dG) causes G→T versus G→A mutations based upon a correlation between mutagenesis and molecular modeling results

DNA polymerase II (polB) is involved in a new DNA repair pathway for DNA interstrand cross-links in Escherichia coli

Molecular modeling of the conformational complexity of (+)-anti-B[α]PDE-adducted DNA using simulated annealing

Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens

DNA guanine-guanine crosslinking sequence specificity of isophosphoramide mustard, the alkylating metabolite of the clinical antitumor agent ifosfamide

How are potent bulky carcinogens able to induce such a diverse array of mutations?

The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: perspective, prospects and problems

Synthesis of a duplex oligonucleotide containing a nitrogen mustard interstrand DNA-DNA cross-link

Mapping the binding site of aflatoxin B1 in DNA: systematic analysis of the reactivity of aflatoxin B1 with guanines in different DNA sequences

AP sites are not significantly involved in mutagenesis by the (+)anti diol epoxide of benzo[a]pyrene : the complexity of its mutagenic specificity is likely to arise from adduct conformational polymorphism

A violation of the Swain-Scott principle, and not SN1 versus SN2 reaction mechanisms, explains why carcinogenic alkylating agents can form different proportions of adducts at oxygen versus nitrogen in DNA

Evidence for a Recombination-Independent Pathway for the Repair of DNA Interstrand Cross-Links Based on a Site-Specific Study with Nitrogen Mustard

[23] Molecular modeling in mutagenesis and carcinogenesis

Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells

Sequence Specific Mutagenesis of the Major (+)-anti-Benzo[a]pyrene Diol Epoxide−DNA Adduct at a Mutational Hot Spot in Vitro and in Escherichia coli Cells

Evidence from in vitro Replication that O6-Methylguanine can Adopt Multiple Conformations

Construction of a human shuttle vector containing a single nitrogen mustard interstrand, DNA-DNA cross-link at a unique plasmid location

Construction of Escherichia coli vectors containing deoxyadenosine and deoxyguanosine adducts from (+)-anti-dibenz[a,j]anthracene diol epoxide at a defined site

The major, N2-dG adduct of (+)-anti-B[a]PDE induces G→A mutations in a 5'-AGA-3' sequence context

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