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A mutator phenotype in cancer

Cancer research (Chicago, Ill.), 2001-04, Vol.61 (8), p.3230-3239

LOEB, Lawrence A

2001

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Significance of multiple mutations in cancer

Carcinogenesis (New York), 2000-03, Vol.21 (3), p.379-385

2000

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Functional Interaction between the Werner Syndrome Protein and DNA Polymerase δ

Proceedings of the National Academy of Sciences - PNAS, 2000-04, Vol.97 (9), p.4603-4608

2000

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Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

Nucleic acids research, 1998-06, Vol.26 (12), p.2879-2885

1998

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8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions

The Journal of biological chemistry, 1992-01, Vol.267 (1), p.166-172

1992

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Mutator phenotype may be required for multistage carcinogenesis

Cancer research (Chicago, Ill.), 1991-06, Vol.51 (12), p.3075-3079

LOEB, L. A

1991

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The Werner syndrome gene : the molecular basis of RecQ helicase-deficiency diseases

Trends in genetics, 2000-05, Vol.16 (5), p.213-220

2000

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Genetic Instability and the Mutator Phenotype: Studies in Ulcerative Colitis

The American journal of pathology, 1999-06, Vol.154 (6), p.1621-1626

1999

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Getting a grip on how DNA polymerases function

Nature structural & molecular biology, 2001-08, Vol.8 (8), p.656-659

2001

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Multiple Amino Acid Substitutions Allow DNA Polymerases to Synthesize RNA

The Journal of biological chemistry, 2000-12, Vol.275 (51), p.40266-40272

2000

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Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA

Nucleic acids research, 2000-09, Vol.28 (17), p.3260-3268

2000

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Creation of Drug-Specific Herpes Simplex Virus Type 1 Thymidine Kinase Mutants for Gene Therapy

Proceedings of the National Academy of Sciences - PNAS, 1996-04, Vol.93 (8), p.3525-3529

1996

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The contribution of endogenous sources of DNA damage to the multiple mutations in cancer

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001-06, Vol.477 (1), p.7-21

2001

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Tandem Double CC → TT Mutations are Produced by Reactive Oxygen Species

Proceedings of the National Academy of Sciences - PNAS, 1993-05, Vol.90 (9), p.3904-3907

1993

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Microsatellite instability: marker of a mutator phenotype in cancer

Cancer research (Chicago, Ill.), 1994-10, Vol.54 (19), p.5059-5063

Loeb, L A

1994

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Thermus aquaticus DNA polymerase I mutants with altered fidelity. Interacting mutations in the O-helix

The Journal of biological chemistry, 2000-10, Vol.275 (42), p.32728-32735

2000

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Reverse Chemical Mutagenesis: Identification of the Mutagenic Lesions Resulting from Reactive Oxygen Species-Mediated Damage to DNA

Proceedings of the National Academy of Sciences - PNAS, 1994-07, Vol.91 (14), p.6609-6613

1994

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Mutagenesis by Apurinic/Apyrimidinic Sites

Annual review of genetics, 1986-01, Vol.20 (1), p.201-230

1986

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Mutation spectrum of copper-induced DNA damage

The Journal of biological chemistry, 1991-04, Vol.266 (10), p.6401-6406

1991

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Fidelity of HIV-1 Reverse Transcriptase

Science (American Association for the Advancement of Science), 1988-11, Vol.242 (4882), p.1168-1171

1988

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Mutations in the KRAS2 Oncogene during Progressive Stages of Human Colon Carcinoma

Proceedings of the National Academy of Sciences - PNAS, 1989-04, Vol.86 (7), p.2403-2407

1989

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Lethal mutagenesis of HIV by mutagenic ribonucleoside analogs

AIDS research and human retroviruses, 2000, Vol.16 (1), p.1-3

2000

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The Vinyl Chloride DNA Derivative N2,3-Ethenoguanine Produces G → A Transitions in Escherichia coli

Proceedings of the National Academy of Sciences - PNAS, 1991-11, Vol.88 (22), p.9974-9978

1991

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The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure

Proceedings of the National Academy of Sciences - PNAS, 1994-05, Vol.91 (11), p.4950-4954

1994

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Transient Expression of a Mutator Phenotype in Cancer Cells

Science (American Association for the Advancement of Science), 1997-09, Vol.277 (5331), p.1449-1450

Loeb, Lawrence A.

1997

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A mutator phenotype in cancer

Significance of multiple mutations in cancer

Functional Interaction between the Werner Syndrome Protein and DNA Polymerase δ

Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions

Mutator phenotype may be required for multistage carcinogenesis

The Werner syndrome gene : the molecular basis of RecQ helicase-deficiency diseases

Genetic Instability and the Mutator Phenotype: Studies in Ulcerative Colitis

Getting a grip on how DNA polymerases function

Multiple Amino Acid Substitutions Allow DNA Polymerases to Synthesize RNA

Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA

Creation of Drug-Specific Herpes Simplex Virus Type 1 Thymidine Kinase Mutants for Gene Therapy

The contribution of endogenous sources of DNA damage to the multiple mutations in cancer

Tandem Double CC → TT Mutations are Produced by Reactive Oxygen Species

Microsatellite instability: marker of a mutator phenotype in cancer

Thermus aquaticus DNA polymerase I mutants with altered fidelity. Interacting mutations in the O-helix

Reverse Chemical Mutagenesis: Identification of the Mutagenic Lesions Resulting from Reactive Oxygen Species-Mediated Damage to DNA

Mutagenesis by Apurinic/Apyrimidinic Sites

Mutation spectrum of copper-induced DNA damage

Fidelity of HIV-1 Reverse Transcriptase

Mutations in the KRAS2 Oncogene during Progressive Stages of Human Colon Carcinoma

Lethal mutagenesis of HIV by mutagenic ribonucleoside analogs

The Vinyl Chloride DNA Derivative N2,3-Ethenoguanine Produces G → A Transitions in Escherichia coli

The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure

Transient Expression of a Mutator Phenotype in Cancer Cells

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