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JNJ-64794964 (AL-034/TQ-A3334), a TLR7 agonist, induces sustained anti-HBV activity in AAV/HBV mice via non-cytolytic mechanisms

Antiviral research, 2021-12, Vol.196, p.105196-105196, Article 105196

2021

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Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

PloS one, 2020-12, Vol.15 (12), p.e0240338

2020

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Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target

Angewandte Chemie (International ed.), 2010-02, Vol.49 (9), p.1652-1655

2010

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In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

Antimicrobial Agents and Chemotherapy, 2010-05, Vol.54 (5), p.1878-1887

2010

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Tracking the Evolution of Multiple In Vitro Hepatitis C Virus Replicon Variants under Protease Inhibitor Selection Pressure by 454 Deep Sequencing

Journal of Virology, 2010-11, Vol.84 (21), p.11124-11133

2010

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Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

Bioorganic & medicinal chemistry, 2008-09, Vol.18 (17), p.4853-4858

2008

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TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage

Antimicrobial Agents and Chemotherapy, 2012-09, Vol.56 (9), p.4676-4684

2012

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Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

Angewandte Chemie (International ed.), 2012-05, Vol.51 (19), p.4637-4640

2012

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Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (13), p.4437-4443

2012

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Mechanism and Specificity of a Symmetrical Benzimidazolephenylcarboxamide Helicase Inhibitor

Biochemistry (Easton), 2010-03, Vol.49 (9), p.1822-1832

2010

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Antiviral Suppression vs Restoration of RIG-I Signaling by Hepatitis C Protease and Polymerase Inhibitors

Gastroenterology (New York, N.Y. 1943), 2008-11, Vol.135 (5), p.1710-1718.e2

2008

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The influenza virus ion channel and maturation cofactor M2 is a cholesterol-binding protein

European biophysics journal, 2005-02, Vol.34 (1), p.52-66

2005

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An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients

Antiviral research, 2024-04, Vol.224, p.105835-105835, Article 105835

2024

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Development of a high-content screening assay to identify compounds interfering with the formation of the hepatitis C virus replication complex

Journal of virological methods, 2010-05, Vol.165 (2), p.268-276

2010

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In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

Antimicrobial Agents and Chemotherapy, 2009-04, Vol.53 (4), p.1377-1385

2009

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Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Antimicrobial Agents and Chemotherapy, 2011-08, Vol.55 (8), p.3812-3820

2011

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Nucleotide Prodrugs of 2′-Deoxy-2′-spirooxetane Ribonucleosides as Novel Inhibitors of the HCV NS5B Polymerase

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1836-1844

2014

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Discovery of 1‑((2R,4aR,6R,7R,7aR)‑2-Isopropoxy-2-oxidodihydro‑4H,6H‑spiro[furo[3,2‑d][1,3,2]dioxaphosphinine-7,2′-oxetan]-6-yl)pyrimidine-2,4(1H,3H)‑dione (JNJ-54257099), a 3′-5′-Cyclic Phosphate Ester Prodrug of 2′-Deoxy-2′-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition

Journal of medicinal chemistry, 2016-06, Vol.59 (12), p.5790-5798

2016

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Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: Exploration of P2 quinazoline substituents

Bioorganic & medicinal chemistry letters, 2010-07, Vol.20 (14), p.4004-4011

2010

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Corrigendum: Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target

Angewandte Chemie (International ed.), 2010-04, Vol.49 (19), p.3250-3250

2010

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Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1880-1892

2014

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Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.1843-1849

2007

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2′-Deoxy-2′-spirocyclopropylcytidine Revisited: A New and Selective Inhibitor of the Hepatitis C Virus NS5B Polymerase

Journal of medicinal chemistry, 2010-11, Vol.53 (22), p.8150-8160

2010

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Definitive Assignment of Proton Selectivity and Attoampere Unitary Current to the M2 Ion Channel Protein of Influenza A Virus

Journal of Virology, 2001-04, Vol.75 (8), p.3647-3656

2001

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1,5-Benzodiazepine inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2492-2496

2009

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JNJ-64794964 (AL-034/TQ-A3334), a TLR7 agonist, induces sustained anti-HBV activity in AAV/HBV mice via non-cytolytic mechanisms

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target

In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

Tracking the Evolution of Multiple In Vitro Hepatitis C Virus Replicon Variants under Protease Inhibitor Selection Pressure by 454 Deep Sequencing

Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage

Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055

Mechanism and Specificity of a Symmetrical Benzimidazolephenylcarboxamide Helicase Inhibitor

Antiviral Suppression vs Restoration of RIG-I Signaling by Hepatitis C Protease and Polymerase Inhibitors

The influenza virus ion channel and maturation cofactor M2 is a cholesterol-binding protein

An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients

Development of a high-content screening assay to identify compounds interfering with the formation of the hepatitis C virus replication complex

In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Nucleotide Prodrugs of 2′-Deoxy-2′-spirooxetane Ribonucleosides as Novel Inhibitors of the HCV NS5B Polymerase

Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: Exploration of P2 quinazoline substituents

Corrigendum: Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target

Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors

2′-Deoxy-2′-spirocyclopropylcytidine Revisited: A New and Selective Inhibitor of the Hepatitis C Virus NS5B Polymerase

Definitive Assignment of Proton Selectivity and Attoampere Unitary Current to the M2 Ion Channel Protein of Influenza A Virus

1,5-Benzodiazepine inhibitors of HCV NS5B polymerase

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