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The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (24), p.6501-6504

2008

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Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts

Molecular cancer therapeutics, 2004-11, Vol.3 (11), p.1427-1438

2004

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Magnetic Resonance Imaging Determination of Tumor Grade and Early Response to Temozolomide in a Genetically Engineered Mouse Model of Glioma

Clinical cancer research, 2007-05, Vol.13 (10), p.2897-2904

2007

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Design and Synthesis of 2-Nitroimidazoles with Variable Alkylating and Acylating Functionality

Chemical and Pharmaceutical Bulletin, 2014/03/01, Vol.62(3), pp.301-303

2014

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Radiosensitization by Pan ErbB Inhibitor CI-1033 in Vitro and in Vivo

Clinical cancer research, 2004-01, Vol.10 (2), p.691-700

2004

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A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

Science (American Association for the Advancement of Science), 1994-08, Vol.265 (5175), p.1093-1095

1994

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Dynamic imaging of emerging resistance during cancer therapy

Cancer research (Chicago, Ill.), 2006-05, Vol.66 (9), p.4687-4692

2006

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Tyrosine Kinase Inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(Phenylamino)pyrido[d]pyrimidine Acrylamides as Irreversible Inhibitors of the ATP Binding Site of the Epidermal Growth Factor Receptor

Journal of medicinal chemistry, 1999-05, Vol.42 (10), p.1803-1815

1999

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Abstract 5194: Focal radiation enhances paclitaxel therapy in a mouse model of triple negative breast cancer

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.5194-5194

2017

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The influence of tumor size and environment on gene expression in commonly used human tumor lines

BMC cancer, 2004-07, Vol.4 (1), p.35-35, Article 35

2004

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Specific, Irreversible Inactivation of the Epidermal Growth Factor Receptor and erbB2, by a New Class of Tyrosine Kinase Inhibitor

Proceedings of the National Academy of Sciences - PNAS, 1998-09, Vol.95 (20), p.12022-12027

1998

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Plasma vascular endothelial growth factor and interleukin-8 as biomarkers of antitumor efficacy of a prototypical erbB family tyrosine kinase inhibitor

Molecular cancer therapeutics, 2005-06, Vol.4 (6), p.938-947

2005

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3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and Related 2-Urea Derivatives Are Potent and Selective Inhibitors of the FGF Receptor-1 Tyrosine Kinase

Journal of medicinal chemistry, 2000-11, Vol.43 (22), p.4200-4211

2000

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Differential Utilization and Localization of ErbB Receptor Tyrosine Kinases in Skin Compared to Normal and Malignant Keratinocytes

Neoplasia (New York, N.Y.), 2001, Vol.3 (4), p.339-350

2001

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Abstract B15: Increased clinical relevance of orthotopic glioma models through bioluminescence and MR imaging

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.B15-B15

2013

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Design and Synthesis of 2-Nitroimidazoles with Variable Alkylating and Acylating Functionality

Chemical and Pharmaceutical Bulletin, 2014-03, Vol.62 (3), p.301-303

2014

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2-Alkylamino-and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (23), p.6171-6174

2008

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Abstract 3929: Orthotopic human choroidal melanoma model characterization with bioluminescence and magnetic resonance imaging for therapeutic efficacy evaluation

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.3929-3929

2014

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Abstract B142: Evaluating the feasibility and throughput of quintuple modality imaging in disseminated models of cancer with PET, CT, MRI, bioluminescence, and fluorescence molecular tomography

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.B142-B142

2013

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Radiosensitization of p53 mutant cells by pd0166285, a novel G2 checkpoint abrogator

Cancer research (Chicago, Ill.), 2001-11, Vol.61 (22), p.8211-8217

2001

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Abstract 3859: Characterization of imaging-enhanced models of disseminated multiple myeloma

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.3859-3859

2013

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C-Terminal Modifications of Histidyl-N-benzylglycinamides To Give Improved Inhibition of Ras Farnesyltransferase, Cellular Activity, and Anticancer Activity in Mice

Journal of medicinal chemistry, 1997-10, Vol.40 (21), p.3319-3322

1997

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Abstract 5243: Value of 1H magnetic resonance spectroscopy compared with anatomical imaging in predicting response to standard chemotherapy and radiation in U87-MG-luc intracranial glioma model

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.5243-5243

2010

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Abstract 4321: A four-pronged imaging approach to characterization of bone metastasis in mouse models

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.4321-4321

2010

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Abstract 5242: Bioluminescence imaging of radiation induced tumor growth inhibition in orthotopic mouse models

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.5242-5242

2010

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The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts

Magnetic Resonance Imaging Determination of Tumor Grade and Early Response to Temozolomide in a Genetically Engineered Mouse Model of Glioma

Design and Synthesis of 2-Nitroimidazoles with Variable Alkylating and Acylating Functionality

Radiosensitization by Pan ErbB Inhibitor CI-1033 in Vitro and in Vivo

A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

Dynamic imaging of emerging resistance during cancer therapy

Tyrosine Kinase Inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(Phenylamino)pyrido[d]pyrimidine Acrylamides as Irreversible Inhibitors of the ATP Binding Site of the Epidermal Growth Factor Receptor

Abstract 5194: Focal radiation enhances paclitaxel therapy in a mouse model of triple negative breast cancer

The influence of tumor size and environment on gene expression in commonly used human tumor lines

Specific, Irreversible Inactivation of the Epidermal Growth Factor Receptor and erbB2, by a New Class of Tyrosine Kinase Inhibitor

Plasma vascular endothelial growth factor and interleukin-8 as biomarkers of antitumor efficacy of a prototypical erbB family tyrosine kinase inhibitor

3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and Related 2-Urea Derivatives Are Potent and Selective Inhibitors of the FGF Receptor-1 Tyrosine Kinase

Differential Utilization and Localization of ErbB Receptor Tyrosine Kinases in Skin Compared to Normal and Malignant Keratinocytes

Abstract B15: Increased clinical relevance of orthotopic glioma models through bioluminescence and MR imaging

Design and Synthesis of 2-Nitroimidazoles with Variable Alkylating and Acylating Functionality

2-Alkylamino-and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

Abstract 3929: Orthotopic human choroidal melanoma model characterization with bioluminescence and magnetic resonance imaging for therapeutic efficacy evaluation

Abstract B142: Evaluating the feasibility and throughput of quintuple modality imaging in disseminated models of cancer with PET, CT, MRI, bioluminescence, and fluorescence molecular tomography

Radiosensitization of p53 mutant cells by pd0166285, a novel G2 checkpoint abrogator

Abstract 3859: Characterization of imaging-enhanced models of disseminated multiple myeloma

C-Terminal Modifications of Histidyl-N-benzylglycinamides To Give Improved Inhibition of Ras Farnesyltransferase, Cellular Activity, and Anticancer Activity in Mice

Abstract 5243: Value of 1H magnetic resonance spectroscopy compared with anatomical imaging in predicting response to standard chemotherapy and radiation in U87-MG-luc intracranial glioma model

Abstract 4321: A four-pronged imaging approach to characterization of bone metastasis in mouse models

Abstract 5242: Bioluminescence imaging of radiation induced tumor growth inhibition in orthotopic mouse models

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